Vahap Saricicek

The radioprotective effect of Nigella sativa on nitrosative stress in lens tissue in radiation-induced cataract in rat.

Abstract Objective: The aim of this study was to investigate the antioxidant and radioprotective effects of Nigella sativa oil (NSO) and thymoquinone (TQ) against ionizing radiation-induced cataracts in lens after total cranium irradiation (IR) of rats with a single dose of 5 gray (Gy). Materials and methods: Seventy-four Sprague-Dawley rats were used for the experiment. The rats were randomly divided into six groups. Group A received total cranium IR plus NSO (1 g kg–1 d–1) orally through an orogastric tube. Group B received total cranium IR plus TQ (50 mgkg–1 d–1) daily by intraperitoneal injection. Group C received 5 Gy of gamma IR as a single dose to total cranium plus 1 ml saline. Group D1 just received 1 ml saline. Group D2 just received dimethyl sulfoxide. Group D3 did not receive anything. Results: At the end of the 10th d, cataract developed in 80% of the rats in IR group only. After IR, cataract rate dropped to 20% and 50% in groups which were treated with NSO and TQ, respectively, and was limited at grades 1 and 2. Nitric oxide synthase activity, nitric oxide and peroxynitrite levels in the radiotherapy group were higher than those of all other groups. Conclusions: The results implicate a major role for NSO and TQ in preventing cataractogenesis in ionizing radiation-induced cataracts in the lenses of rats, wherein NSO were found to be more potent.

Endotracheal intubation of a paediatric patient with an umbrella wire embedded in the palate to the posterior wall of the nasopharynx using a GlideScope video laryngoscope

The penetration of foreign bodies into the oropharynx can be life-threatening. Airway management in patients who have a foreign body penetrated into their oropharynx is a challenging problem for the anaesthetist. In this case report, we aimed to share our experience of endotracheal intubation performed with GlideScope video laryngoscopy in a 3-year-old, 15 kg patient. The patient underwent general anaesthesia to facilitate the removal of an umbrella wire that had become embedded in her soft palate.

Glidescope Video Laryngoscope Use for Tracheal Intubation in a Patient with CHARGE Syndrome.

CHARGE syndrome is an autosomal dominant syndrome in which ocular coloboma (C), heart defects (H), choanal atresia (A), growth retardation (R), genital hypoplasia (G), ear abnormalities (E), and tracheoesophageal fistula, dysphagia, cleft palate, micrognathia, facial paralysis, hypopituitarism, and brain abnormalities may be seen in patients. The patients with CHARGE syndrome face surgical procedures many times from birth. Especially, the problems we meet in the airway may be special. In this case report, we aimed to share our experience of endotracheal intubation performed with Glidescope video laryngoscopy for a patient at the age of 20 months, weight 7.5 kg and height 70 cm, with CHARGE syndrome who was undergoing cochlear implantation.

The comparison of the effectiveness of the ultrasound and peripheral nerve stimulating techniques during interscalen block

There are potential advantages and disadvantages during ultrasonographic and peripheral nerve stimulating techniques in interscalen plexus blockade. In this study, we aimed to compare the sensory and motor blockade onset time and the duration of postoperative analgesic requirement during interscalen blockade performed with ultrasound and peripheral nerve stimulating techniques. Sixty patients in ASA (American Society of Anesthesiologysts) 1-2 groups were accepted in this prospective and double blind study for the shoulder surgery. Twenty-five ml 0.5% Levobupivacaine was administered to each patient group. The sensory blockade was evaluated with Pinprick test and the motor blockade was evaluated with the Bromage Scale. The duration of the sensorial and the motor blockade and the duration of postoperative first analgesic requirement were noted. The demographic data were similar between the groups. The onset time of sensorial and the motor blockades in group U was significantly shorter than in group S and the first analgesic requirement time in group U was significantly longer than in group S. During the interscalen blockade performed with ultrasound and peripheral nerve stimulator, it was observed that the sensorial and motor blockade was developed faster and the duration of first analgesic requirement was longer with ultrasound technique. Furthermore, it was determined that postoperative patient comfort score was more satisfied by ultrasound technique.