Valentin Ouedraogo

Évaluation de la déformabilité érythrocytaire des sujets porteurs de trait drépanocytaire au cours d’un match de football : effet de l’hydratation ad libitum

This study compared erythrocyte changes between a group of subjects with sickle cell trait (SCT) and controls (subjects without hemoglobinopathy) during a soccer game in two conditions: with and without hydration. Erythrocyte deformability of subjects was assessed by the coefficient of erythrocyte rigidity (Tk) which was calculated before and after football match. Our results showed a significant increase in erythrocyte rigidity (Tk) in SCT at the end of physical activities without hydration; however when water was provided ad libitum their Tk decreased significantly, reaching values of controls. And adequate hydration is recommended in subjects with sickle cell trait during and after exercise.

Insulin resistance and arterial stiffness: impact of gestational diabetes on pulse wave velocity

Background: Gestational diabetes is an intolerance of glucose with the first appearance during the pregnancy. This hyperglycaemia status, because of the pre-existing insulin-resistance, constitute a favourable land of arterial stiffness. The aim of this study is to determine the impact of non obese gestational diabetes on arterial stiffness by measuring the pulse wave velocity (PWV). Methods: We recruited 60 pregnant women aged from 20 to 35 years old. They were between twentieth four and thirtieth five weeks of gestational age. Subjects were divided into two groups: the first group (G1), considered as control group, included 25 normoglycemic pregnant subjects without any history of illness or risk factors of gestational diabetes; the second group (G2) included 35 women with Gestational Diabetes Mellitus (GDM). All pregnant women had not history of smoking, were not taking decoction or medicine, which could disturb pregnancy evolution. Anthropo-physiological and biochemical parameters studied, were: age, body mass index (BMI), blood pressure (BP), triglyceride, cholesterol and HOMA-IR index. The PWV between finger and toe (PWVft) was measured by pOpmètre®. Results: The two groups are matched by age (G1:28±4ans; G2:29±3ans) and BMI (G1:25.6±1.27; G2:26.9±1.3). Blood pressure (BP) values are in normal interval (systolic BP: [110-132mmHg]; diastolic BP: [63-87mmHg]; mean BP: [79-103mmHg]). Total cholesterol (G1:0.95±0.08;G2:2.4±0.7; p˂0.0001), HDL cholesterol (G1:0.44±0.02; G2:0.76±0.2; p˂0.0001, LDL cholesterol (G1:0.40±0.05; G2:1.3±0.5; p˂0.0001), triglyceride (G1:0.57±0.45; G2:1.6±0.4;p˂0.0001), HOMA.IR (G1:1.31±1.05; G2:7.4±1.07; p˂0.01), PWVft (G1:5.99±1.23; G2:10.3±1.9; p˂0.0001) are significantly higher in diabetic group. PWVft is positively correlate to HOMA-IR index, total cholesterol, LDL cholesterol and triglycerides (r=0.3348, p=0.032; r=0.5275, p˂0.0001; r=0.4855,p˂0.0001; r=0.5581, p˂0.0001respectively). Conclusions: Gestational diabetes might induce an increase of pulse wave velocity expressing increment of arterial stiffness. This last constitute an early underlying cardiovascular risk.

Evaluation of vascular function in depigmented black women: Comparative study

Background: Prolonged application of skin depigmenting substances could expose human organism to serious general complications such as hypertension or diabetes. Artificial depigmentation (AD) is a widespread practice within Sub-Saharan Africa subjects. AD is based on the use of dermocorticoides which could lead to vascular complications. Aims and Objectives: Our aim was to evaluate the vascular function in depigmented Senegalese women. Materials and Methods: Thirty six depigmented (depigmented group) and 36 undepigmented black women (control group) participated in the study. They were aged 33.10 ± 7 years and 30.22 ± 6 years, respectively. Brachial artery flow mediated dilation (FMD) was measured in two groups. Biochemical and cardiovascular profiles of our study population were evaluated. The duration of depigmenting products exposure was evaluated in depigmented subjects. Results: Our study showed an abnormal kinetic of FMD in depigmented group compared to control group. Mean arterial pressure was 95.9 ± 8.8 mmHg in depigmented subjects and 89.6 ± 6.2 mmHg for control subjects and a significant difference was observed (P = 0.002) while triglycerides was significantly different (P = 0.01) between the two groups (0.8 ± 0.3 and 0.6 ± 0.2 g/L, respectively). FMD was significantly and positively correlated with exposure time (r = 0.25; P = 0.029). Conclusion: Prolonged percutaneous application of depigmentation products could alter metabolic and vascular functions, and consequently install cardiovascular risks. Thus, we recommended ways to prevent of AD in the African population.

Recovery of Body Composition after the Fasting of Ramadan in Young Sub-Saharan African Athletes

The fasting of Ramadan is causing circadian rhythm and body composition changes. It has been described a decrease of certain parameters during this period. Thus, the objective of our study was to evaluate the recovery of these parameters after the fasting of Ramadan. An experimental study was carried out among 18 students of the National Institute of Sciences of Physical Education and Sport (INSEPS) in Dakar. They were all male, black, aged 21 to 30 years and regularly practiced fasting. Data were collected on the 15th day of Ramadan and 6 weeks after Ramadan. Anthropometric and cardiovascular parameters were measured. Body mass index (BMI) was calculated from the anthropometric parameters such as weight and size by Quetelet’s formula. The parameters of body composition such as percentages of body fat, muscle mass and visceral fat were measured by an impedance meter (OMRON BF 511). Then, they allowed us to calculate percentage of fat free mass, fat free mass index (FFMI) and skeletal muscle mass index (SMMI). No significant difference was found for cardiovascular parameters between the two periods. However, certain parameters such as weight, BMI, fat mass, fat free mass and FFMI increased significantly six weeks after Ramadan. A strong trend of increasing was found in the percentage of fat mass (p = 0.05), while the percentage of muscle mass slightly tended to decrease after Ramadan. The principal component analysis showed that the percentages of body fat, fat free mass and muscle mass as well as fat mass were the most contributory parameters of the body composition in both times. The fasting of Ramadan causes transient changes in body composition. Long-term changes in certain parameters such as fat mass were necessary for a real effect on health. The association of Ramadan fasting with that of Sunnah would be necessary to obtain this benefit.

Évaluation de la déformabilité érythrocytaire des sujets porteurs de trait drépanocytaire au cours d'un match de football : effet de l'hydratation ad libitum Evaluation of erythrocyte deformability in subjects with sickle cell trait during a soccer game: effect of hydration ad libitum

This study compared erythrocyte changes between a group of subjects with sickle cell trait (SCT) and controls (subjects without hemoglobinopathy) during a soccer game in two conditions: with and without hydration. Erythrocyte deformability of subjects was assessed by the coefficient of erythrocyte rigidity (Tk) which was calculated before and after football match. Our results showed a significant increase in erythrocyte rigidity (Tk) in SCT at the end of physical activities without hydration; however when water was provided ad libitum their Tk decreased significantly, reaching values of controls. And adequate hydration is recommended in subjects with sickle cell trait during and after exercise.