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Dive into the research topics where Valentin Titus Grigorean is active.

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Featured researches published by Valentin Titus Grigorean.


Neurologia Medico-chirurgica | 2013

Cauda equina intradural extramedullary cavernous haemangioma: case report and review of the literature.

Mihai Popescu; Valentin Titus Grigorean; Crina Julieta Sinescu; Lupaşcu C; George Popescu; Aurelia Mihaela Sandu; Iancu Emil Plesea

Cavernous haemangioma (cavernoma) is a benign vascular lesion, exceptionally located in cauda equina. We report a case, diagnosed and operated in the Department of Neurosurgery from Pitesti County Emergency Hospital, of a 60-year-old woman with history of lumbar region distress, who presented with low back pain, paravertebral muscle contracture, and bilateral lumbar radiculopathy, with sudden onset after lifting effort. The preoperative diagnosis was done using computed tomography (CT) and magnetic resonance imaging (MRI), and the patient underwent surgery—two level laminectomy, dural incision, and tumor dissection from the cauda equina nerve roots under operatory microscope. Histopathological examination confirmed the positive diagnosis of cavernoma of cauda equina. The patients outcome was favorable, without postoperative neurological deficits.


Gastroenterology Research and Practice | 2014

Hind Right Approach Pancreaticoduodenectomy: From Skill to Indications

Georgescu S; Ursulescu C; Valentin Titus Grigorean; Lupaşcu C

Background. Pancreaticoduodenectomy is the potentially curative treatment for malignant and several benign conditions of the pancreatic head and periampullary region. While performing pancreaticoduodenectomy, early neck division may be impossible or inadequate in case of hepatic artery anatomic variants, suspected involvement of the superior mesenteric vessels, intraductal papillary mucinous neoplasm, and pancreatic head bleeding pseudoaneurysm. Our work aims to highlight a particular hind right approach pancreaticoduodenectomy in selected indications and assess the preliminary results. Methods. We describe our early hind right approach to the retropancreatic vasculature during pancreaticoduodenectomy by mesopancreas dissection before any pancreatic or digestive transection. Results. We used this approach in 52 patients. Thirty-two had hepatic artery anatomic variant and 2 had bleeding pancreatic head pseudoaneurysm. The hepatic artery variant was preserved in all cases out of 2 in which arterial reconstruction was performed. In nine patients with intraductal papillary mucinous neoplasms the pancreaticoduodenectomy was extended to the body in 6 and totalized in 3 patients. Seven patients with adenocarcinoma involving the portomesenteric axis required venous resection and reconstruction. Conclusions. Early hind right approach is advocated in selected cases of pancreaticoduodenectomy to improve locoregional vascular control and determine, safely and early, whether there is mesopancreas involvement.


Surgical Innovation | 2017

Ventriculoportal Shunt, a New Transomphalic Extraperitoneal Surgical Technique in Treatment of Hydrocephalus

Valentin Titus Grigorean; Aurelia Mihaela Sandu; Mihai Popescu; Victor Strambu

Aim. The aim of this article was to report a new transomphalic extraperitoneal surgical technique for treatment of hydrocephalus, called ventriculoportal shunt. Materials and Methods. We performed ventriculoportal shunt on an experimental animal (pig). The particularity of ventriculoportal shunt consists in the fact that the distal end of the catheter is inserted transomphalic extraperitoneally in the portal system through reopened umbilical vein. We present technical details regarding this new surgical technique. Results and Discussion. The animal had favorable outcome, without any postoperative early or late morbidity. We discuss indications, contraindications, possible complications in humans and advantages of ventriculoportal shunt compared with ventriculocardiac and ventriculoperitoneal drainages and possibilities to avoid complications specific to classic shunt procedures. Conclusions. Ventriculoportal shunt is a new surgical technique for treatment of hydrocephalus. The distal end of the catheter introduced into reopened umbilical vein, drains cerebrospinal fluid into the portal system. Ventriculoportal shunt is safe and easy to perform. With ventriculoportal shunt specific complications of ventriculoperitoneal or ventriculocardiac drainages can be potentially avoided. Ventriculoportal shunt combines advantages of vascular shunt with those of having an immunological barrier for cerebrospinal fluid before entering the systemic circulation. Theoretically, indications for surgery are extended, and ventriculoportal shunt can be performed in patients former contraindicated for ventriculoperitoneal shunt. Further research is needed and this surgical technique must be performed on human subjects with hydrocephalus.


Neurologia I Neurochirurgia Polska | 2017

Our initial experience with ventriculo-epiplooic shunt in treatment of hydrocephalus in two centers

Valentin Titus Grigorean; Aurelia Mihaela Sandu; Mihai Popescu; Ioan Stefan Florian; Lupaşcu C; Ursulescu C

INTRODUCTION Hydrocephalus represents impairment in cerebrospinal fluid (CSF) dynamics. If the treatment of hydrocephalus is considered difficult, the repeated revisions of ventriculo-peritoneal (VP) shunts are even more challenging. OBJECTIVE The aim of this article is to evaluate the efficiency of ventriculo-epiplooic (VEp) shunt as a feasible alternative in hydrocephalic patients. MATERIAL AND METHODS A technical modification regarding the insertion of peritoneal catheter was imagined: midline laparotomy 8-10cm long was performed in order to open the peritoneal cavity; the great omentum was dissected between its two layers; we placed the distal end of the catheter between the two epiplooic layers; a fenestration of 4cm in diameter into the visceral layer was also performed. A retrospective study of medical records of 15 consecutive patients with hydrocephalus treated with VEp shunt is also presented. RESULTS Between 2008 and 2014 we performed VEp shunt in 15 patients: 5 with congenital hydrocephalus, 8 with secondary hydrocephalus and 2 with normal pressure hydrocephalus. There were 7 men and 8 women. VEp shunt was performed in 13 patients with multiple distal shunt failures and in 2 patients, with history of abdominal surgery, as de novo extracranial drainage procedure. The outcome was favorable in all cases, with no significant postoperative complications. CONCLUSIONS VEp shunt is a new, safe and efficient surgical technique for the treatment of hydrocephalus. VEp shunt is indicated in patients with history of recurrent distal shunt failures, and in patients with history of open abdominal surgery and high risk for developing abdominal complications.


Gastroenterology Research and Practice | 2017

Emergency Backwards Whipple for Bleeding: Formidable and Definitive Surgery

Lupaşcu C; Ana Trofin; Mihai Zabara; Alexandra Vornicu; Ramona Cadar; Vlad N; Oana Apopei; Valentin Titus Grigorean; Corina Lupascu-Ursulescu

Introduction During the past decades, the safety of pancreatoduodenectomy has improved, with low mortality and reduced morbidity, particularly in centers with extensive experience. Emergency pancreatoduodenectomy is an uncommon event, for treatment of pancreaticoduodenal trauma, bleeding, or perforation. We herein present a single center experience concerning nontrauma emergency pancreatoduodenectomy for pancreaticoduodenal bleeding. Methods From January 2007 to December 2015, from a population of 134 PD (70 males and 64 females, mean age 62.2, range 34–82), 5 patients (3.7%; 2 males and 3 females, mean age 64, range 57–70) underwent one-stage emergency pancreatoduodenectomy for uncontrollable nontrauma pancreaticoduodenal bleeding in our tertiary center. Results All the 5 patients underwent a backwards Whipple with a morbidity of 60% and a mortality of 20% (1/5). The other 4 patients were recovered and discharged with a median postoperative length of stay of 17 days (range 14–23). Conclusion Emergency pancreatoduodenectomy is a definitive life-saving procedure allowing for a rapid control of bleeding when other less invasive approaches (transcatheter arterial embolization or interventional endoscopy) are exhausted, unavailable, or unsafe. It should be particularly considered in neoplastic disease and tailored by surgeons with a high level of experience in pancreatic surgery.


Journal of medicine and life | 2010

Vascular dysfunctions following spinal cord injury

Popa C; Popa F; Valentin Titus Grigorean; Gelu Onose; Aurelia Mihaela Sandu; Mihai Popescu; Burnei G; Strambu; Sinescu C


Journal of medicine and life | 2010

Molecular basis of vascular events following spinal cord injury.

Sinescu C; Popa F; Valentin Titus Grigorean; Gelu Onose; Aurelia Mihaela Sandu; Mihai Popescu; Burnei G; Strambu; Popa C


Journal of medicine and life | 2009

Laparoscopic treatment of abdominal complications following ventriculoperitoneal shunt

Popa F; Valentin Titus Grigorean; Gelu Onose; Mihai Popescu; Victor Strambu; Aurelia Mihaela Sandu


Archive | 2012

HISTOPATHOLOGICAL CHANGES IN THE LIVER AND KIDNEY TISSUES OF MARSH FROG (Pelophylax ridibundus) INDUCED BY THE ACTION OF TALSTAR 10EC INSECTICIDE

Cristina Maria Ponepal; Valentin Titus Grigorean; Mihai Popescu


Romanian journal of morphology and embryology | 2012

Spinal involvement with spinal cord compression syndrome in hematological diseases.

Mihai Popescu; Popov; Popescu G; Dobrea C; Aurelia Mihaela Sandu; Valentin Titus Grigorean; Strâmbu

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Lupaşcu C

Grigore T. Popa University of Medicine and Pharmacy

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Iancu Emil Plesea

University of Medicine and Pharmacy of Craiova

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Gelu Onose

Carol Davila University of Medicine and Pharmacy

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Mihai Popescu

Carol Davila University of Medicine and Pharmacy

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Victor Strambu

Carol Davila University of Medicine and Pharmacy

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Aurelian Anghelescu

Carol Davila University of Medicine and Pharmacy

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Roxana Andreea Rahnea Nita

Carol Davila University of Medicine and Pharmacy

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