Vandana Dialani

Increased Cancer Detection Rate and Variations in the Recall Rate Resulting from Implementation of 3D Digital Breast Tomosynthesis into a Population-based Screening Program

PURPOSE To compare the recall and cancer detection rates (CDRs) at screening with digital breast tomosynthesis (DBT) with those at screening with two-dimensional (2D) mammography and to evaluate variations in the recall rate (RR) according to patient age, risk factors, and breast density and among individual radiologists at a single U.S. academic medical center. MATERIALS AND METHODS This institutional review board-approved, HIPAA-compliant prospective study with a retrospective cohort included 85 852 asymptomatic women who presented for breast cancer screening over a 3-year period beginning in 2011. A DBT unit was introduced into the existing 2D mammography screening program, and patients were assigned to the first available machine. Ten breast-subspecialized radiologists interpreted approximately 90% of the examinations. RRs were calculated overall and according to patient age, breast density, and individual radiologist. CDRs were calculated. Single and multiple mixed-effect logistic regression analyses, χ(2) tests, and Bonferroni correction were utilized, as appropriate. RESULTS The study included 5703 (6.6%) DBT examinations and 80 149 (93.4%) 2D mammography examinations. The DBT subgroup contained a higher proportion of patients with risk factors for breast cancer and baseline examinations. DBT was used to detect 54.3% more carcinomas (+1.9 per 1000, P < .0018) than 2D mammography. The RR was 7.51% for 2D mammography and 6.10% for DBT (absolute change, 1.41%; relative change, -18.8%; P < .0001). The DBT subgroup demonstrated a significantly lower RR for patients with extremely or heterogeneously dense breasts and for patients in their 5th and 7th decades. CONCLUSION Implementing DBT into a U.S. breast cancer screening program significantly decreased the screening RR overall and for certain patient subgroups, while significantly increasing the CDR. These findings may encourage more widespread adoption and reimbursement of DBT and facilitate improved patient selection.

MR volumetry of brain and CSF in fetuses referred for ventriculomegaly.

OBJECTIVE The purpose of this study was to validate the method of performing fetal brain volumetry. In particular, our objectives were to assess which imaging plane is most reproducible for the performance of brain volumetry measurements and to ascertain inter- and intraobserver variability in determining brain volume in fetuses referred for ventriculomegaly (VM). SUBJECTS AND METHODS In this prospective study, 50 consecutive fetuses at 17-37 weeks of gestational age referred for MRI for VM underwent fast spin-echo T2-weighted imaging. Supratentorial brain parenchyma, lateral ventricles, and extraaxial and cerebellar volumetric measurements were manually obtained in three planes by three radiologists. Inter- and intraobserver variability were assessed. The relationship between volumes and gestational age, and lateral ventricular diameter were assessed. RESULTS Volumes increased with gestational age. The presence of VM correlated with increased lateral ventricle diameter. The effect of imaging plane was negligible. Inter- and intraobserver variability were low. CONCLUSION Supratentorial parenchyma and lateral ventricular volumes can be reliably measured on fetal MRI, and imaging plane was not an important factor in measurement. Further studies are needed to correlate these indexes with long-term postnatal outcomes.

Evaluation of Real-Time Single-Shot Fast Spin-Echo MRI for Visualization of the Fetal Midline Corpus Callosum and Secondary Palate

OBJECTIVE The objective of our study was to assess the visibility of the fetal corpus callosum and soft palate on standard single-shot fast spin-echo (SSFSE) imaging versus real-time (RT) SSFSE imaging. SUBJECTS AND METHODS Part 1 of the study was a prospective analysis using a questionnaire rating the ease of use and utility of RT imaging. Part 2 of the study was a retrospective analysis of 69 fetal MRI studies with RT sagittal midline imaging of the head, face, or both. Standard and RT SSFSE image sets were de-identified, randomized, and shown to three pediatric neuroradiologists who rated on a 5-point scale whether the images were midline and how well they could see and characterize as normal the corpus callosum and secondary palate. The imaging results were correlated with postnatal diagnosis. Statistical methods included the Wilcoxons signed rank test, McNemar chi-square test, and analysis of variance. RESULTS Prospectively, the RT SSFSE technique was ranked as excellent in all the categories assessed. Retrospective analysis showed that the midline view obtained with RT SSFSE imaging was helpful in diagnosing the normal and abnormal secondary palate, allowing improved diagnosis of 19 (30.6%) of 62 cases of normal palate and four (57.1%) of seven cases of abnormal palate, when compared with the standard SSFSE technique. RT SSFSE imaging improved the ability to diagnose a normal corpus callosum on the midline view in 13 (27.6%) of 47 fetuses of 20 or more weeks gestational age. CONCLUSION The RT SSFSE technique can aid in obtaining images in planes that are critical to the evaluation of a moving fetus, particularly when a midline sagittal view of the corpus callosum or palate is required. The use of this technique may lead to improved diagnosis of CNS or orofacial abnormalities in fetuses.

MDCT Detection of Airway Stent Complications: Comparison with Bronchoscopy

OBJECTIVE The objective of our study was to evaluate the detection rate of central airway stent complications using MDCT as compared with bronchoscopy. MATERIALS AND METHODS A review was performed of all consecutive patients undergoing MDCT and bronchoscopy for suspected complications of airway stents during an 18-month period. MDCT images were interpreted in a blinded fashion by an experienced thoracic radiologist before bronchoscopy was performed, and the accuracy of MDCT was determined using bronchoscopy as the gold standard. MDCT images were specifically assessed for the presence of the following complications: narrowing of stent lumen due to granulation tissue or secretions (or both), stent fracture, stent invasion by adjacent neoplasm, stent migration, and perforation of adjacent airways. RESULTS The study population was composed of 21 patients, with mean age of 48 years (range, 16-79 years), who underwent tracheal (n = 3), tracheobronchial (n = 7), or bronchial (n = 11) stent placement for benign (n = 13) or malignant (n = 8) airway disorders. Eleven of 21 stents were metallic and the remaining 10 were silicone. Thirty complications were detected in 21 patients, including stent luminal narrowing due to granulation tissue or secretions (or both) (n = 13), stent migration (n = 9), stent fracture (n = 4), stent invasion by adjacent neoplasm (n = 3), and tracheal perforation (n = 1). MDCT accurately detected 29 (97%) of the 30 complications diagnosed by bronchoscopy. There was one false-negative case in which MDCT failed to detect a stent fracture. There were no false-positive diagnoses of stent complications. CONCLUSION MDCT is highly accurate for detecting airway stent complications.

Does Isolated Flat Epithelial Atypia on Vacuum-assisted Breast Core Biopsy Require Surgical Excision?

To determine whether flat epithelial atypia (FEA) found in isolation on large core vacuum‐assisted biopsy (CNB) requires surgical excision. After Institutional Review Board approval, pathology reports of all patients who underwent CNB from January 1, 2005 to December 31, 2010 were reviewed. All patients with reports of isolated FEA without other atypia or in situ or invasive carcinoma were identified. Patient age, history, target on imaging, biopsy modality, and residual target post CNB noted. Histology of CNBs (blinded to surgical outcome) and subsequent surgical excisions were reviewed by a dedicated breast pathologist. Only cases with confirmed isolated FEA on review were used for data analysis. Of 2,556 CNBs performed over 6 years, 37 (1.4%) had isolated FEA confirmed on review, comprising our study population. Thirty (81%) had biopsy for calcifications on mammography and 7 (19%) for mass or non‐mass like enhancement on magnetic resonance imaging. There were no US guided CNBs that met our inclusion criteria. 29 (78.4%) underwent surgical excision, 6 (16.2%) had imaging follow‐up, and 2 (5.4%) were lost to follow‐up. Of the 29 with surgery, 2 (6.9%) had “upgrade” to low‐grade in situ carcinoma (1 ductal and 1 pleomorphic lobular), 5 (17.2%) had “change in diagnosis” to other atypia (ADH/ALH), 15 (51.7%) had additional FEA and 7 (24.2%) had benign tissue without atypia. Both “upgraded” cases had residual microcalcifications on imaging following CNB. There were no upgrades to invasive cancers. In our study, none of 29 with isolated FEA on CNB had invasive cancer on surgical excision. If there are residual microcalcifications or residual lesion after a CNB that shows isolated FEA, excision is warranted, due to the possibility of other atypia (ADH/ALH [17.2%] or DCIS [5.4%]). If there are no residual microcalcifications following CNB, imaging follow‐up as an alternative to surgery may be a reasonable option.

Stereotactic core biopsy: Comparison of 11 gauge with 8 gauge vacuum assisted breast biopsy☆

PURPOSE The compare the performance and ability to obtain a correct diagnosis on needle biopsy between 11 gauge and 8 gauge vacuum assisted biopsy devices. MATERIALS AND METHODS Hospital records of all consecutive stereotactic core biopsies performed over five years were retrospectively reviewed in compliance Health Insurance Portability and Accountability Act (HIPPA) policy and with approval from the hospital institutional review board (IRB). Pathology from core biopsy was compared with surgical pathology and/or imaging follow-up. A histological underestimation was defined if the surgical excision yielded a higher grade on pathology which changed management. RESULTS 828 needle core biopsies (47.5%, 393/828 with 11 gauge and 52.5%, 435/828 with 8 gauge) yielded 471 benign, 153 high risk and 204 malignant lesions. 30/193 (15.5%) 11 gauge lesions and 16/185 (8.6%) 8 gauge lesions demonstrated higher grade pathology on surgical excision. The difference in the rates of the number of correct diagnoses on core needle biopsy between 11 gauge (363/393, 92.4%) and 8 gauge (419/435, 96.3%) based on either surgical or clinical/imaging follow up and the difference in the number of discordant benign core biopsies between 11 (17/217, 7.8%) and 8 gauge (4/254, 1.6%) necessitating a surgical biopsy was significant (P=0.013; P=0.001). Although there were more underestimations with the 11 gauge (25/193, 13.0%) than 8 gauge (15/185, 8.1%) needle, this was not significant. CONCLUSION Our study demonstrates improved performance and increased diagnostic ability of 8 gauge needle over 11 gauge in obtaining a correct diagnosis on needle biopsy.

Architectural distortion of the breast.

Benign Causes of Architectural Distortion Radial Scars and Complex Sclerosing Lesions Both radial scars and complex sclerosing lesions result from idiopathic processes unrelated to trauma or postsurgical change. They are characterized microscopically by radiating ducts and lobules that show varying degrees of hyperplasia, adenosis, ectasia, or papillomatosis. Complex sclerosing lesions are usually larger than 1 cm and display more proliferative tissue than radial scars. Because most patients are asymptomatic and the lesions are not palpable, radial scars and complex sclerosing lesions are usually discovered as incidental findings on screening mammography. However, they pose a diagnostic challenge because they closely mimic scirrhous carcinomas. The typical mammographic appearance is a radiolucent central core with spiculated radiations, at times associated with microcalcifications (Fig. 1). On ultrasound, radial scars commonly present as a hypoechoic mass or parenchymal distortion that mimics malignancy. On MRI, the morphologic features and contrast enhancement patterns of radial scars and complex sclerosing lesions cannot reliably differentiate a benign from malignant process. There is only limited evidence supporting the rate of enhancement as a useful differentiating factor. Because of the inability to reliably differentiate radial scars and complex sclerosing lesions from carcinoma, the lesion must be biopsied and excised.

Mucocele-Like Lesions in the Breast Diagnosed With Percutaneous Biopsy: Is Surgical Excision Necessary?

OBJECTIVE The purpose of this study was to determine the frequencies of atypia and cancer at excisional biopsy of lesions with a diagnosis of mucocele-like lesion (MLL) at percutaneous breast biopsy. MATERIALS AND METHODS Retrospective review of 9286 lesions subjected to percutaneous imaging-guided biopsy identified MLLs in 35 (0.38%) patients. Medical records, imaging studies, and histologic results were reviewed. RESULTS Of the 35 patients with core biopsy findings of MLL, 27 underwent stereotactic core needle biopsy (19 with microcalcifications, five with calcifications with an associated mass, and three with only a mass), and eight underwent ultrasound-guided core needle biopsy (four with a solid mass, three with a complex cystic mass). At core biopsy, 12 of 35 (34%) MLLs were associated with atypia (10 cases of atypical ductal hyperplasia, two of flat epithelial atypia), and 23 of 35 (66%) were benign MLL only. All 12 MLLs associated with atypia and 12 of 23 benign MLLs were surgically excised. Eleven patients did not undergo surgery, five of whom were lost to follow-up. One of the 12 (3% of the 35) MLLs associated with atypia was upgraded to DCIS. None were upgraded to invasive cancer. None of the benign MLLs were upgraded to malignancy, and findings at excision of four of the 23 (17%) benign MLLs led to a change in diagnosis to a high-risk lesion (three atypical ductal hyperplasia, one atypical lobular hyperplasia). CONCLUSION MLL is a rare diagnosis but is encountered in large-volume breast practices. The findings are nonspecific with a range of imaging appearances. No imaging test is reliable for differentiating MLL from other suspicious lesions or lesions with associated atypia. Surgery is clearly warranted for MLL associated with atypia at core needle biopsy because it may be upgraded to malignancy upon excision. However, if the presence of atypia at excision of benign MLL will change clinical management, then benign MLL at core needle biopsy warrants surgical excision in some cases. In patients whose treatment will not change if atypia is found at excision, close surveillance with short-interval follow-up is a reasonable alternative.

Sonographic Features of Gynecomastia

Objective. The purpose of this study was to identify sonographic features of gynecomastia. Methods..A retrospective analysis was performed on all male patients with breast symptoms imaged with breast sonography over a 5‐year period. Breast sonograms in 158 men were jointly reviewed by 3 investigators. Sonograms were assessed for the presence or absence of a mass: (1) if mass present, (a) location of the mass, (b) vascularity, (c), axis, (d) appearance of posterior tissues, and (e) tissue echo texture; and (2) if mass absent, anteroposterior (AP) depth at the nipple (increased if >1 cm). Results. Of the 237 men with breast symptoms, 79 with only mammography were excluded. Of the 158 who had sonography with or without mammography, 5 without gynecomastia were also excluded. A total of 153 men included in the study presented with pain (n = 38), a lump (n = 95), both pain and a lump (n = 17), or nipple discharge (n = 3). Nine of 153 with gynecomastia had a biopsy. A total of 219 sonographic examinations were performed, which revealed 73 masses (33%): 20 (27%) nodular, 20 (27%) poorly defined, and 33 (45%) flame shaped. All masses were retroareolar, with 57 (78%) hypoechoic, 54 (73%) avascular, 60 (82%) parallel to the chest wall, and 47 (64%) without posterior enhancement or shadowing. Of the 146 without masses (67%), 141 (97%) had increased AP depth at the nipple. Conclusions. Gynecomastia is a clinical diagnosis, and mammography is the primary imaging modality when indicated. However, if sonography is used when mammography is declined or when mammography is inconclusive, it is important to recognize the various described patterns of gynecomastia to avoid unnecessary biopsy based on sonographic findings.

A practical approach to imaging the axilla

AbstractImaging of the axilla typically occurs when patients present with axillary symptoms or newly diagnosed breast cancer. An awareness of the axillary anatomy is essential in order to generate an accurate differential diagnosis and guide patient management. The purpose of this article is to review the indications for axillary imaging, discuss the logistics of the scanning technique and percutaneous interventions, and present the imaging findings and management of a variety of breast diseases involving the axilla. Teaching points • Knowledge of normal axillary anatomy aids in determining the aetiology of an axillary mass.• The differential diagnosis of an axillary mass is broad and can be subdivided by the location of the lesion.• Imaging evaluation of the axilla usually entails diagnostic mammography and targeted ultrasound.• FNA or core needle biopsies are safe and accurate methods for diagnosis and guiding management.