Varun Manhas

Computational modelling of local calcium ions release from calcium phosphate-based scaffolds

A variety of natural or synthetic calcium phosphate (CaP)-based scaffolds are currently produced for dental and orthopaedic applications. These scaffolds have been shown to stimulate bone formation due to their biocompatibility, osteoconductivity and osteoinductivity. The release of the

Biocompatible solid particles for controlled instigation of cavitation during therapeutic ultrasound.

\hbox {Ca}^{2+}

Modelling BMP-2 carrier device for bone tissue engineering application

Ca2+ ions from these scaffolds is of great interest in light of the aforementioned properties. It can depend on a number of biophysicochemical phenomena such as dissolution, diffusion and degradation, which in turn depend on specific scaffold characteristics such as composition and morphology. Achieving an optimal release profile can be challenging when relying on traditional experimental work alone. Mathematical modelling can complement experimentation. In this study, the in vitro dissolution behaviour of four CaP-based scaffold types was investigated experimentally. Subsequently, a mechanistic finite element method model based on biophysicochemical phenomena and specific scaffold characteristics was developed to predict the experimentally observed behaviour. Before the model could be used for local

Investigating in vitro calcium dissolution using a mathematical model

\hbox {Ca}^{2+}

AN IN-SILICO MODEL OF BMP-2 CARRIER DEVICE FOR BONE TISSUE ENGINEERING APPLICATION

Ca2+ ions release predictions, certain parameters such as dissolution constant (