Vedula Girija Sastry

Trocheliophorin: A novel rearranged sesquiterpenoid from the Indian Ocean soft coral Sarcophyton trocheliophorum

A novel rearranged sesquiterpenoid, trocheliophorin (1) has been isolated from the soft coral Sarcophyton trocheliophorum besides the known compounds, sarcophytin, methyl arachidonate, and two polyhydroxy steroids (24S)-24-methylcholestane-3β,5α,6β,25-tetrol-25-monoacetate and (24S)-24-methylcholestane-3β,5α,6β,25-tetrol. The structure of the new sesquiterpenoid was elucidated by a study of its spectral data.

A New Spiroketal Steroid from Gorgonella Umbraculum

A new spiroketal steroid ( 2 ) was isolated from the Indian Ocean gorgonian, Gorgonella umbraculum besides the known briarane diterpenoids, juncellin, umbraculides A and D. The new steroid was characterised as 22-acetoxy-3,25-dihydroxy-16-24,20-24-bisepoxy-(3 g , 16 f , 20 S , 22 R , 24 S )-cholest-5-ene ( 2 ) by a study of its spectral data.

Design, synthesis, spectroscopic characterization and anti-psychotic investigation of some novel Azo dye/Schiff base/Chalcone derivatives

Abstract The purpose of the study is to design, synthesise and assess the antipsychotic activity of a set of the novel (5-(10-(3-N, N-Dimethylamino) propyl)-10H-phenothiazine-3-yl)-1,3,4-thiadiazo-2-yl) Azodye/Schiff base/Chalcone derivatives. The newly synthesised compound structure was characterised by FT-IR, 1H NMR, Mass spectroscopy and elemental analysis. Each compound has been shown an excellent anti-psychotic activity in a haloperidol-induced catalepsy metallic bar test. The results found are firmly similar to docking study. Among the synthesised derivatives, compound 2-Amino-6-(3-hydroxy-4-methylphenyl) pyrimidine-4-yl) (7-chloro-10-(3-(N, N-dimethylamino) propyl)-10H-phenothiazine-3-yl) methanone (GC8) exhibiting high potency of catalepsy induction. Therefore, the derivative of GC8 has been considered that a potent anti-psychotic agent among the synthesised compounds.

Occurrences, mechanism of action, structural activity relationship and various pharmacological activities of thiadiazole and their derivatives

In the recent times, many people around the world are suffering drug resistant in most of the antibiotics used in different circumferences. In order to overcome the antibiotic resistance problem, there is need to use of existing antibiotics consciously and prepare novel compounds which exhibit high therapeutic profile against different pathogens with least resistance. In this review we discussed the thiadiazole derivatives and their different biological activities such as anti-inflammatory, anti-helicobacter pylori, anti-microbial, anti-cancer, antiviral, anti-depressant, analgesic, herbicidal and adenosine A3 receptor inhibitor, besides that this review also provides a detailed information about structural activity relationship (SAR) of such a compounds prepared by different medicinal chemist to date. In general, SAR is the smartest tool among the medicinal chemist to create a better therapeutic efficacy and high safety bioactive molecule in a short span of time. Besides that, we pointed out here different challenges of thiadiazole derivatives and its feature perspectives.