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Featured researches published by Velit Halit.


Scandinavian Cardiovascular Journal | 1997

Psychiatric complications of cardiac surgery postoperative delirium syndrome.

Levent Gökgöz; Serdar Gunaydin; Volkan Sinci; M. Unlu; C. Boratav; A. Babacan; Halim Soncul; Velit Halit; S. Inanir; Ali Ersöz

Psychiatric disturbances due to cardiopulmonary bypass, especially postoperative delirium syndrome, are among the immediate complications of open-heart surgery. In a series of 32 male and 18 female patients the prevalence of such disorders was investigated and search was made for possible risk factors for their occurrence. Psychiatric, neurologic and electroencephalographic evaluation was made pre- and postoperatively, in addition to haemodynamic, echocardiographic, angiographic and regional cerebral blood flow studies. Nine of the 50 patients had significantly reduced perfusion of certain cerebral lobes in single photon emission computed tomography, and in six of them the psychiatric tests indicated postoperative delirium; three of these six also had moderate electroencephalographic changes. The cerebral hypoperfusion persisted on day 15 in four patients, while psychiatric tests were negative. The study showed possible risk factors to be patient age, long aortic cross-clamp time, high-dose inotropic support and excessive transfusion of blood or blood products.


Anz Journal of Surgery | 2007

Preoperative beta-blocker use reduces atrial fibrillation in off-pump coronary bypass surgery.

Yildirim Imren; Ariel A. Benson; Hakan Zor; Irfan Tasoglu; Emrah Ereren; Volkan Sinci; Levent Gökgöz; Velit Halit

Background:  Atrial fibrillation (AF) after coronary artery bypass graft surgery constitutes the most common sustained arrhythmia and results in many complications. The purpose of this study was to assess the effects of prophylactic use of beta‐blockers against atrial fibrillation in off‐pump surgery patients in the early postoperative period.


Scandinavian Journal of Clinical & Laboratory Investigation | 2001

Biochemical and hemodynamic effects of ascorbic acid and alpha-tocopherol in coronary artery surgery.

G. L. Oktar; Volkan Sinci; Sedat Kalaycioglu; Halim Soncul; Levent Gökgöz; Velit Halit; Ali Ersöz

This study was undertaken to evaluate the effects of alpha-tocopherol and ascorbic acid on markers of myocardial reperfusion injury and myocardial contractile function after coronary artery surgery. Forty-eight patients were divided into 4 groups; 300 mg/day alpha-tocopherol was given orally to the patients in group I for 14 days. In groups II and III, 4 g of ascorbic acid was administered intravenously prior to induction and in the cardioplegic solution, respectively. Group IV was the control group. Blood samples were taken to determine the concentrations of creatine phosphokinase MB isoenzyme, malondialdehyde, uric acid, ascorbic acid and alpha-tocopherol in the perioperative period. Left ventricular functions were determined by means of MUGA scans and echocardiography preoperatively and on the 3rd and 7th days, postoperatively. The changes in serum creatine phosphokinase MB and malondialdehyde were significantly lower in study groups, when compared with the control group. We observed no significant changes in ventricular function, requirement for (+) inotropic agents and the incidence of ventricular arrhythmias among the groups, postoperatively. Biochemical findings are consistent with the free radical hypothesis. But we could not confirm these data with hemodynamic findings. This is probably due to the population of low-risk elective coronary surgery patients in this study.


Surgery Today | 2007

Corpus Sterni Reinforcement Improves the Stability of Primary Sternal Closure in High-Risk Patients

Erkan Iriz; Dilek Erer; Pinar Koksal; Mehmet Emin Ozdogan; Velit Halit; Volkan Sinci; Levent Gökgöz; Ali Yener

PurposeTo compare standard sternal closure techniques with reinforcement longitudinal wire placement in the corpus sterni in high-risk patients undergoing open-heart surgery via median sternotomy.MethodsThe subjects of this study were 71 high-risk patients, 32 (45%) of whom underwent sternal closure by conventional methods (group 1) and 39 (55%) of whom underwent sternal closure with corpus sterni reinforcement. The patients were followed up for a mean period of 90 days.ResultsIn group 2, none of the patients had sternal dehiscence and no revision was required, but in group 1, five (15.5%) patients had sternal dehiscence. This difference was significant between the groups (P = 0.024), but there were no significant differences in mediastinitis and mortality (P > 0.05).ConclusionsOur findings suggest that primary sternal closure with longitudinal wire reinforcement on both sides of the corpus sterni will decrease the risk of infection and improve wound-healing in parallel with a decrease in sternal dehiscence.


The Journal of Thoracic and Cardiovascular Surgery | 1994

The role of selenium added to pulmonary preservation solutions in isolated guinea pig lungs

Halim Soncul; Melih Kaptanoğlu; Eser Öz; Velit Halit; Ayşe Bilgehan; Banu Çayci; Levent Gökgöz; Nurten Türkozan; Ali Ersöz

An experimental comparative study on isolated guinea pig lungs has been undertaken to determine the probable beneficial effects of adding selenium to pulmonary preservation solutions in lung ischemia. The isolated lungs (n = 10 in each group) previously being perfused by oxygenated Krebs-Henseleit solution were put in normothermic ischemic conditions just after the infusion of 30 ml of pulmonary preservation solution (Euro-Collins in the control group, Euro-Collins plus selenium 10(-3) mol in the experiment group). After 3 hours of normothermic ischemia the lungs were reperfused with the same buffer for 20 minutes. Pulmonary artery pressures, tissue malondialdehyde levels, and adenosine deaminase levels of the perfusate were measured before and after the ischemic period and also at the end of reperfusion. An electron microscopic analysis was performed on the lung tissues at the end of the experimental procedure. According to our data, the addition of selenium to pulmonary preservation solution showed a significant protective effect regarding both ischemic and reperfusion injury.


Amino Acids | 2002

The role of taurine added to pulmonary reperfusion solutions in isolated guinea pig lungs

Eser Öz; M. C. Sivrikoz; Velit Halit; A. Altunkaya; Gulnur Take

Summary. An experimental comparative study on isolated guinea pig-lungs has been undertaken to determine the probable beneficial effects of adding taurine to pulmonary reperfusion solutions in lung ischemia-reperfusion. 20 guinea pigs were used. The isolated lungs (n = 10 in each group) previously being perfused by oxygenated Krebs-Henseleit solution were put in normothermic ischemic conditions. After 3 hours of normothermic ischemia the lungs were reperfused (with Krebs-Henseleit solution in the control group, Krebs-Henseleit solution plus taurine 10−2 M in the experiment group) for 20 minutes. Pulmonary artery pressures, tissue malondialdehyde (MDA) and glutathione (GSH) levels were measured before and after the ischemic period and also at the end of reperfusion. Malondialdehyde and glutathione levels of the pefusate were measured before ischemic period and at the end of reperfusion. An electron microscopic analysis was performed on the lung tissues before and after the ischemic period and also at the end of reperfusion. Decreased pulmonary artery pressure, tissue perfusate MDA levels and increased perfusate GSH levels were observed in taurine added group. Electron microscopic evaluation supported our findings indicating preservation of lamellar bodies of type II pneumocytes. It is concluded that taurine may play an important role in protecting tissue against ischemia-reperfusion injury by functioning as an antioxidant.


Surgery Today | 2008

Traditional single patch versus the "Australian" technique for repair of complete atrioventricular canal defects.

Velit Halit; Gursel Levent Oktar; Veli Yildirim Imren; Erkan Iriz; Dilek Erer; Serdar Kula; Fatma Sedef Tunaoglu; Levent Gökgöz; Rana Olguntürk

PurposeA variety of operative techniques has been used to repair complete atrioventricular (AV) canal defects and satisfactory outcomes after single patch repairs have been reported. We report our comparative results of repairing complete AV canal defects between 1998 and 2006 using the traditional single patch and the “Australian” techniques.MethodsFourteen patients underwent traditional AV canal repair with the single patch technique (Group 1) and 11 patients underwent repair with the “Australian” technique (Group 2). All patients were examined with preoperative echocardiography and cardiac catheterization, and were followed up with echocardiography to evaluate AV valve and ventricular function.ResultsThere were two early postoperative deaths in Group 1 and one in Group 2. One patient from each group had moderate left AV valve regurgitation postoperatively, but none from either group had left ventricular outflow obstruction.ConclusionsThe “Australian” technique is a simpler method requiring shorter aortic cross-clamping and total bypass times with good clinical and functional results. The early postoperative results are as encouraging as those achieved by the traditional single patch technique; however, long-term follow-up results are required to establish the efficacy of this simplified technique.


Molecular and Cellular Biochemistry | 2006

Role of the nitric oxide pathway in ischemia-reperfusion injury in isolated perfused guinea pig lungs

Aykut Altunkaya; Eser Öz; M. Cumhur Sivrikoz; Velit Halit; Nuran Yener; Deniz Erdo an; Candan Özo ul

We examined the role of the nitric oxide (NO) pathway on ischemia-reperfusion injury via the use of isolated perfused guinea pig lungs.We administered both L-Arginine and N-nitro-L-arginine methyl ester (L-NAME) to the lungs in or after 3 h of ischemia.We observed pulmonary artery pressures as well as tissue and perfusate malondialdehyde (MDA) and glutathione (GSH) levels. We observed that L-NAME significantly increased both tissue and perfusate GSH levels and pulmonary artery pressures, but it decreased both tissue and perfusate MDA levels. On the other hand, L-arginine significantly decreased pulmonary artery pressure and both tissue and perfusate glutathione levels, but it increased both tissue and perfusate MDA levels. Electron microscopic evaluation supported our findings by indicating the preservation of lamellar bodies of type II pneumocytes.We concluded that L-NAME administration during reperfusion improves lung recovery from ischemic injury.


Scandinavian Cardiovascular Journal | 1997

Bland-White-Garland Syndrome in an Adult: Case Report and Review of Diagnostic and Predictive Strategies

Serdar Gunaydin; Levent Gökgöz; M. Unlu; Volkan Sinci; Halim Soncul; Mehmet Metin; S. Inanir; Velit Halit

In a 27-year-old man with Bland-White-Garland syndrome (anomalous origin of the left coronary artery from the pulmonary artery), comparison was made between conventional diagnostic techniques and radionuclide imaging for selection of surgical procedure and evaluating the outcome. Dynamic 99mTc imaging exactly located the left coronary artery orifice, which was not seen on angiography, thereby determining the surgical approach, and 123I study revealed that, despite absence of symptoms, the adrenergic activity of the heart was globally diminished, with limited response to revascularization.


The Anatolian journal of cardiology | 2012

First virtual interactive symposium with synchronous distance education techniques.

Serdar Kula; Velit Halit; Levent Oktar

Address for Correspondence/Yaz›şma Adresi: Dr. Serdar Kula, Gazi Üniversitesi Tıp Fakültesi, Pediyatrik Kardiyoloji Bölümü, Ankara-Türkiye Phone: +90 312 202 56 26 E-mail: [email protected] Accepted Date/Kabul Tarihi: 10.02.2012 Available Online Date/Çevrimiçi Yayın Tarihi: 06.04.2012 ©Telif Hakk› 2012 AVES Yay›nc›l›k Ltd. Şti. Makale metnine www.anakarder.com web sayfas›ndan ulaş›labilir. ©Copyright 2012 by AVES Yay›nc›l›k Ltd. Available on-line at www.anakarder.com doi:10.5152/akd.2012.101 Serdar Kula, Velit Halit*, Levent Oktar*

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