Venkateshwarlu Jetti

Prediction of theoretical physicochemical properties and one-pot synthesis of bis-azetidinones by [2+2] ketene--imine cycloaddition in the presence of montmorillonite.

A simple, highly efficient and environmentally friendly microwave accelerated one-pot synthesis of a series of differently substituted bis-azetidinones have been synthesized expeditiously in good yields from 1,2-diaminoethane and aromatic aldehydes in the presence of zeolite. The structures of the newly synthesized compounds were confirmed by IR, NMR, and mass spectra. The design and calculated molecular properties of all the reported compounds are on the basis of hypothetical antibacterial pharmacophores, which were formulated to interact with microorganisms. A correlation of structure and activity relationship of these compounds with respect to Lipinski rules and drug likeness properties of drugs are described and verified experimentally.

A green and convenient approach for the synthesis of 1,10-phenanthrolines via a catalyst- and solvent-free condition

An atom-efficient, catalyst-free, and one-pot multicomponent condensation of 8-hydroxyquinoline, aromatic aldehyde, acetoacetanilide, and ammonium acetate under solvent-free conditions is reported. This eco-friendly protocol offers several advantages such as a green and cost-effective procedure with excellent yield, shorter reaction time, simpler work-up, convergence, and facile automation.