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Featured researches published by Venu Velagapudi.


Journal of Electrocardiology | 2017

Computer-assisted image processing 12 lead ECG model to diagnose hyperkalemia

Venu Velagapudi; John C. O'Horo; Anu Vellanki; Stephen P. Baker; Rahul Pidikiti; Jeffrey S. Stoff; Dennis A. Tighe

BACKGROUND We sought to develop an improved 12 lead ECG model to diagnose hyperkalemia by use of traditional and novel parameters. METHODS We retrospectively analyzed ECGs in consecutive hyperkalemic patients (serum potassium (K)>5.3mEq/L) by blinded investigators with normokalemic ECGs as internal controls. Potassium levels were modeled using general linear mixed models followed by refit with standardized variables. Optimum sensitivity and specificity were determined using cut point analysis of ROC-AUC. RESULTS The training set included 236 ECGs (84 patients) and validation set 97 ECGs (23 patients). Predicted K=(5.2354)+(0.03434*descending T slope)+(-0.2329*T width)+(-0.9652*reciprocal of new QRS width>100msec). ROC-AUC in the validation set was 0.78 (95% CI 0.69-0.88). Maximum specificity of the model was 84% for K>5.91 with sensitivity of 63%. CONCLUSION ECG model incorporating T-wave width, descending T-wave slope and new QRS prolongation improved hyperkalemia diagnosis over traditional ECG analysis.


Archives of Medicine | 2017

Long-term Mortality Outcomes of Hyperkalemic Patients in the Emergency Department Setting: A Case Control Study

Venu Velagapudi; John C. O’Horo; Vladimir Glinskii; Mazen Al-Quadi; Philimon Gona; Aimee R Kroll-Desrosiers; Anu Vellanki; Jeffrey S. Stoff

Background: The impact of an episode of hyperkalemia on long term mortality is not well studied. Such a study is vital for development of a utilization strategy for new drugs for the treatment of hyperkalemia. To study the long term impact of hyperkalemia on mortality, we conducted a retrospective, observational casecontrol study in a tertiary care emergency department. We compared cases of non-hemolyzed serum potassium >5.3 mEq/L with normokalemic controls. Allcause mortality and causes of death were determined from social security death index, national death index, and medical record review over a follow-up period of 490 patient years. Methods and Findings: A total of 287 consecutive subjects (223 cases, 64 controls) were identified among 14,483 patients. Cox proportional hazard regression showed that for each 1 mEq/L increase in admit potassium, all-cause mortality Hazard Ratio was 1.54, 95% Confidence Interval: 1.22-1.96. Subgroup analyses showed higher mortality in acute kidney injury and heart failure patients. Conclusion: Hyperkalemia predicted all-cause mortality, when adjusted for age, sex, Charlson comorbidity index, and significant covariates (heart failure and end stage renal disease). The deleterious effect of admit hyperkalemia persisted in survivors from index episode throughout the study period. Cardiovascular mortality was statistically more prevalent. Future studies are needed for risk stratification strategies and mortality impact of newer drugs.


Chest | 2017

Electrocardiographic Predictors of Mortality in Hyperkalemia

Vladimir Glinskii; Dennis A. Tighe; Anu Vellanki; Jeffrey S. Stoff; Mazen O. Al-Qadi; Venu Velagapudi


Chest | 2017

Ketones and Contention: Bicarbonate Therapy and Clinical Outcomes in Severe Diabetic Ketoacidosis

Alexander Morales; Mohammed Aboelsoud; Faeq Kukhon; Mahmoud Mowafy; Muhammad Ehtisham; Venu Velagapudi; Mazen O. Al-Qadi


Critical Care Medicine | 2015

980: LONGITUDINAL STUDY OF CARDIAC MORTALITY IN HYPERKALEMIC PATIENTS

Venu Velagapudi; Jeffrey S. Stoff; Anu Vellanki; John C. O’Horo; Yazan Haddadin


F1000Research | 2013

Daily fluid balance predicts hospital mortality in critically ill patients receiving continuous renal replacement therapy

Markos Kashiouris; Abbasali Akhoundi; Sanjay Chaudhary; Venu Velagapudi; Andrew P. Goldberg; Kianoush Kashani


Chest | 2013

Computer-Assisted Electrocardiographic Modelling to Predict Severity of Hyperkalemia

Venu Velagapudi; Dennis A. Tighe; Anu Vellanki; Markos Kashiouris; John O Horo; Stephen P. Baker; Jeffrey S. Stoff


Archive | 2011

Outcome of Hyperkalemia in the Emergency Department: Impact of Hyperkalemic Severity, Renal Function and CHF on Survival

Venu Velagapudi; Bruce A. Barton; Jeffrey S. Stoff


American Journal of Kidney Diseases | 2011

338 Successful Outcome in Severe Allograft Failure from Pseudo-Transplant Renal Artery Stenosis

Venu Velagapudi; Ashish Verma; Mohammad H. Eslami; Shimul A. Shah; Pang-Yen Fan; Jeffrey S. Stoff; Ashfaq Balla


American Journal of Kidney Diseases | 2011

339 Mycotic Pseudoaneurysm Related Renal Allograft Failure

Ashish Verma; Venu Velagapudi; Andrew Schanzer; Pang-Yen Fan; Jeffrey S. Stoff; Ashfaq Balla

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Jeffrey S. Stoff

University of Massachusetts Medical School

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Anu Vellanki

University of Massachusetts Medical School

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Dennis A. Tighe

University of Massachusetts Medical School

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Ashfaq Balla

University of Massachusetts Medical School

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Ashish Verma

University of Massachusetts Medical School

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Markos Kashiouris

University of Massachusetts Medical School

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Pang-Yen Fan

University of Massachusetts Medical School

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Stephen P. Baker

University of Massachusetts Medical School

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