Verinder S. Nirankari

Topical Mitomycin-C for subepithelial fibrosis after refractive corneal surgery

OBJECTIVE To determine the effectiveness of mitomycin-C (MMC), 0.02%, in preventing recurrence of corneal subepithelial fibrosis after debridement and/or keratectomy in patients who have undergone refractive corneal surgery. DESIGN Noncomparative case series. PARTICIPANTS Eight eyes of five patients with corneal subepithelial fibrosis who had previously undergone radial keratotomy (n = 4) or photorefractive keratectomy (n = 4). INTERVENTION All eyes underwent epithelial debridement followed by a single intraoperative application of MMC (0.02%) for 2 minutes followed by saline irrigation. The eyes were then patched, or a bandage contact lens placed until epithelial healing was complete. MAIN OUTCOME MEASURES Corneal clarity and best-corrected visual acuity (BCVA). RESULTS In all cases, the cornea remained clear with no recurrence throughout the follow-up period (6-25 mos., mean, 13.8 mos). No adverse reactions were reported. BCVA improved in all cases. CONCLUSIONS Subepithelial fibrosis can be a visually disabling condition after refractive corneal surgery. Topical application of MMC (0.02%) may be a successful method of preventing recurrence of subepithelial fibrosis after debridement.

Anterior Chamber Tube Shunt to an Encircling Band in the Treatment of Neovascular Glaucoma and other Refractory Glaucomas: A Long-term Study

Long-term follow-up results of the anterior chamber tube shunt to an encircling band (ACTSEB) procedure are reported. Thirty eyes of 28 patients with neovascular glaucoma (Group I) and five eyes with non-neovascular refractory glaucoma (Group II) underwent this procedure. In Group I, the average preoperative intraocular pressure (IOP) was 57.1 mmHg. After surgery and average followup of 25 months 96% of eyes had a successful outcome with an average IOP of 15.8 mmHg (P less than 0.001). In Group II, despite multiple glaucoma surgical procedures, the average preoperative IOP was 54 mmHg. After surgery and average followup of 20 months 80% of eyes had a successful outcome with an average IOP of 19.8 mmHg (P less than 0.01). Revisions in our surgical technique utilizing a small entry with a 25-gauge needle into the anterior chamber and use of Healon resulted in a fully formed anterior chamber by two days. Clinical and experimental evidence is presented which suggest that aqueous filters through the tube to a reservoir around the encircling band.

Factors Associated with Glaucoma after Penetrating Keratoplasty

We conducted a retrospective analysis of 80 eyes that underwent penetrating keratoplasties to determine the factors associated with early (less than three months) and late (more than three months) postoperative increases in intraocular pressure. The patients ranged in age from 14 to 91 years (mean age, 58.5 years). The 56 patients with aphakic eyes had a mean age of 64 years and the 24 patients whose eyes had lenses had a mean age of 48 years. In the 17 eyes with preoperative glaucoma, the intraocular pressure was controlled with medication (mean intraocular pressure, 17.6 mm Hg; range, 10 to 21 mm Hg). The follow-up periods ranged from 12 to 26 months (mean, 22 months). Of the 80 eyes, 25 had early increases in intraocular pressure and 23 had late increases. Twenty eyes showed increases during both periods. Of the 17 eyes with preoperative glaucoma, 14 had early increases and 15 had late increases (P less than .001). Of the 57 aphakic eyes, 24 had early increases (P less than .001) and 21 had late increases (P less than .025). Other factors (whether vitrectomy was done, suture technique, and graft size) were not statistically significant.

Clindamycin in the Treatment of Toxoplasmic Retinochoroiditis

We treated 26 patients with acute toxoplasmic retinochoroiditis with clindamycin between 1974 and 1982. Four patients were treated with clindamycin alone and 17 with clindamycin and prednisolone. Five patients received clindamycin and prednisolone, sulfadiazine, pyrimethamine, or cryocoagulation, or a combination of these. All patients with the acute disease had the characteristic foci and a positive titer on the Sabin-Feldman dye test of at least 1:16. Other causes of retinochoroiditis were excluded. All but two patients, who developed diarrhea after two weeks, received clindamycin for a minimum of three weeks. All patients improved after two weeks of treatment, but two patients with lesions larger than 2 disk diameters required an additional six weeks of treatment to heal completely. During follow-up periods ranging from 18 months to seven years (mean, three years) there have been only two recurrences (7.7%). Complications with clindamycin treatment were limited to gastrointestinal upsets, diarrhea, and skin rash. There were no cases of pseudomembranous colitis, the most serious reported complication of clindamycin use.

Persistent Corneal Edema after Collagen Cross-Linking for Keratoconus

PURPOSE To present a new complication of persistent corneal edema after collagen cross-linking (CXL) in keratoconus patients. DESIGN Retrospective case series of postoperative corneal edema after CXL. METHODS study population: All patients who underwent CXL treatment with subsequent corneal edema. Patients with stromal haze were excluded. intervention: The CXL treatments used the Dresden protocol with corneal thickness of more than 400 μm after epithelium was removed. main outcome measure: The resolution of corneal edema after surgery. RESULTS Postoperative corneal edema was identified in 10 (2.9%) of 350 patients who were followed up for a mean of 14 ± 4 months. The edema started on postoperative day 1 (10/10) and increased for 3 weeks. Additional findings included: deep vascularization (2 eyes; 20%), iris atrophy (6 eyes; 60%), pigment dispersion (5 eyes; 50%), persistent epithelial defect (3 eyes; 30%), and infectious keratitis (1 eye; 10%). Specular microscopy was unsuccessful, but the fellow untreated eyes had normal endothelial counts. Intraocular pressure and lenticular evaluations were normal. Corneal edema improved in 4 patients and resolved in 1 patient. In these 5 patients, the logarithm of the minimal angle of resolution best-corrected visual acuity was 0.5 ± 0.18. Penetrating keratoplasty was offered to 5 patients when improvement plateaued at 3 months, but only 2 patients underwent penetrating keratoplasty. CONCLUSIONS CXL is a safe and effective procedure with few known side effects. This case series reports the possibility of corneal endothelial damage with visually significant corneal edema after CXL treatment. Based on the extent of endothelial damage, patients may require penetrating keratoplasty.

Complications of exposed monofilament sutures.

Exposed monofilament suture ends caused a variety of symptoms and signs in 18 patients. These included foreign-body sensation, pain, contact lens intolerance, giant papillary conjunctivitis, tarsal ulceration, conjunctival granuloma, corneal infiltrate, and corneal vascularization. These changes followed cataract surgery, corneal transplantation, and pars plana vitrectomy. Diagnoses in these cases were made by careful slit-lamp examination and by eversion of the upper eyelid. In every case, removal of the sutures or trimming the suture ends resulted in the immediate relief of all symptoms with complete resolution of all signs within two months.

Recurrence of keratoconus in donor cornea 22 years after successful keratoplasty.

reportofrecurrent keratoconus ina43-year-old whitefemale withbilateral penetrating keratoplasties forkeratoconus. Shewas foundtohavea recurrenceofthiscondition intheright eye as manifested byincreasing myopicoblique astigmatism, subepithelial andanterior stromal scarring andcorneal thinning, 22yearsfollowing theinitial grafting procedure. A second successful penetrating keratoplasty was performed. Light andelectron microscopy demonstrated abnormalities inthebasal epithelium, breaks inthebasementmembrane, duplication andthickening ofBowmans layer, andabnormal stromal keratocytes withaccumulation ofgranular intra- andextracellular material. Thesefindings areconsistent with changes asseeninkeratoconus.

Corneal Argon Laser Photocoagulation for Neovascularization in Penetrating Keratoplasty

Corneal argon laser photocoagulation (CALP) was used in 13 patients to treat deep stromal vascular ingrowth. Eight patients had undergone successful penetrating keratoplasty but had developed deep stromal vessels into the graft associated with signs of graft rejection, which did not improve with steroid treatment alone (group 1). After CALP, there was marked regression of the neovascularization with reversal of graft rejection in all eyes. Three additional patients with vascularized corneas, referred for penetrating keratoplasty, underwent CALP preoperatively with obliteration of the vessels (group 2). Two of these patients have since undergone keratoplasty and, in both, the grafts have remained avascular and clear over a 21-month follow-up. Two other patients with corneal injury and progressive corneal opacification and vascularization have also been treated with CALP (group 3). CALP may be a useful adjunct in the treatment of corneal neovascularization. Further clinical studies are needed to define its exact role.

Complications Associated with the Use of the Neodymium:YAG Laser

The neodymium:YAG laser was used in a consecutive series of 93 eyes. Diagnosis was opacified posterior capsule in 81 eyes of which 52 were pseudophakic, with cystoid macular edema and vitreous strands in eight eyes, pigmented anterior hyaloid in two eyes, opacified anterior capsular flap in one eye and vitreous strand blocking an anterior chamber tube shunt to an encircling band tube in one eye. Despite significant visual improvement and reduction of cystoid macular edema, a variety of complications were seen. These included pitting of the implant in 26 eyes and cracks in four, two of which developed a vitreitis. These occurred more frequently in our earlier cases. Also seen was elevated IOP in six eyes, pupillary block in two, vitreous face rupture in five, cystoid macular edema in four, hyphemas in four, corneal injury in two and acute peripheral retinal hemorrhage in one eye.

Prospective Clinical, Study of Radial Keratotomy

A prospective clinical study of radial keratotomy was conducted at the University of Maryland. Results of surgery on 33 eyes of 19 patients with a minimum follow-up of seven months and a mean of 13.8 months are reported. There were eight patients (15 eyes) who needed adequate unaided visual acuity for occupational purposes. Preoperative visual acuity was 20/400 in 79% of eyes. Postoperative visual acuity was 20/50 or better in 48% of cases. However, in patients with preoperative refractive errors of 5 diopters or less, postoperative visual acuity was 20/50 or better in 84% of cases. Average decrease in myopia was 2.5 diopters. Decrease in myopia following radial keratotomy did not correlate with corneal curvature or whether 8 or 16 incision technique was used. However, there was a very significant (P = 0.001) difference in postoperative visual acuity of patients with refractive error of 5 diopters or less, as compared to those with greater than 5 diopters of myopia. Complications included corneal scarring, vascularization, and glare. No microperforation or endothelial cell loss was observed.