Veronika Slonková

Cryopreserved and lyophilized cultured epidermal allografts in the treatment of leg ulcers: a pilot study

Background  In the conservative therapy of venous leg ulcers modern types of dressings are used most frequently. In the past 20 years ‘active wound dressings’ − cultured epidermal keratinocytes as autografts and allografts − were also introduced in the management of leg ulcers.

Genetic predisposition for chronic venous insufficiency in several genes for matrix metalloproteinases (MMP‐2, MMP‐9, MMP‐12) and their inhibitor TIMP‐2

The project was scheduled as a case–control study to investigate the correlation between MMP‐2 (rs243864), MMP‐9 (3918242), MMP‐12 (rs7123600) and TIMP‐2 (rs8176329) polymorphisms and chronic venous disease (CVD) risk. The genotype and phenotype research envisages the testing of possible associations between MMP and TIMP‐2 genotypes and phenotypes of CVD.