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Dive into the research topics where Vicente de Paula Antunes Teixeira is active.

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Featured researches published by Vicente de Paula Antunes Teixeira.


Transplant International | 2008

A Role for galectin‐3 in renal tissue damage triggered by ischemia and reperfusion injury

A.P.F. Bertocchi; Gabriela Campanhole; Pamella Huey Mei Wang; Giselle Martins Gonçalves; M.J. Damião; Marcos Antonio Cenedeze; Felipe Caetano Beraldo; Vicente de Paula Antunes Teixeira; Marlene Antônia dos Reis; Marilda Mazzali; Alvaro Pacheco-Silva; Niels Olsen Saraiva Câmara

Ischemic‐reperfusion injury (IRI) triggers an inflammatory response involving neutrophils/macrophages, lymphocytes and endothelial cells. Galectin‐3 is a multi‐functional lectin with a broad range of action such as promotion of neutrophil adhesion, induction of oxidative stress, mastocyte migration and degranulation, and production of pro‐inflammatory cytokines. The aim of this study was evaluate the role of galectin‐3 in the inflammation triggered by IRI. Galectin‐3 knockout (KO) and wild type (wt) mice were subjected to 45 min of renal pedicle occlusion. Blood and kidney samples were collected at 6, 24, 48 and 120 h. Blood urea was analyzed enzymatically, while MCP‐1, IL‐6 and IL‐1β were studied by real‐time PCR. Reactive oxygen species (ROS) was investigated by flow cytometry. Morphometric analyses were performed at 6, 24, 48 and 120 h after reperfusion. Urea peaked at 24 h, being significantly lower in knockout animals (wt = 264.4 ± 85.21 mg/dl vs. gal‐3 KO = 123.74 ± 29.64 mg/dl, P = 0.001). Galectin‐3 knockout animals presented less acute tubular necrosis and a more prominent tubular regeneration when compared with controls concurrently with lower expression of MCP‐1, IL‐6, IL‐1β, less macrophage infiltration and lower ROS production at early time points. Galectin‐3 seems to play a role in renal IRI involving the secretion of macrophage‐related chemokine, pro‐inflammatory cytokines and ROS production.


BioMed Research International | 2014

Mucosal Immunity in the Female Genital Tract, HIV/AIDS

Juliana Reis Machado; Marcos Vinícius da Silva; Camila Lourencini Cavellani; Marlene Antônia dos Reis; Maria Luíza Gonçalves dos Reis Monteiro; Vicente de Paula Antunes Teixeira; Rosana Rosa Miranda Corrêa

Mucosal immunity consists of innate and adaptive immune responses which can be influenced by systemic immunity. Despite having been the subject of intensive studies, it is not fully elucidated what exactly occurs after HIV contact with the female genital tract mucosa. The sexual route is the main route of HIV transmission, with an increased risk of infection in women compared to men. Several characteristics of the female genital tract make it suitable for inoculation, establishment of infection, and systemic spread of the virus, which causes local changes that may favor the development of infections by other pathogens, often called sexually transmitted diseases (STDs). The relationship of these STDs with HIV infection has been widely studied. Here we review the characteristics of mucosal immunity of the female genital tract, its alterations due to HIV/AIDS, and the characteristics of coinfections between HIV/AIDS and the most prevalent STDs.


Transplant Immunology | 2009

A role for regulatory T cells in renal acute kidney injury.

Rebecca M.M. Monteiro; Niels Olsen Saraiva Camara; Mauricio M. Rodrigues; Fanny Tzelepis; M.J. Damião; Marcos Antonio Cenedeze; Vicente de Paula Antunes Teixeira; Marlene Antônia dos Reis; Alvaro Pacheco-Silva

Ischemia reperfusion injury (IRI) is a potential contributor for the development of chronic allograft nephropathy. T cells are important mediators of injury, even in the absence of alloantigens. We performed a depletion of TCD4(+)CTLA4(+)Foxp3(+) cells with anti-CD25(PC61), a treatment with anti-GITR (DTA-1) and rat-IgG, followed by 45 min of ischemia and 24/72 h of reperfusion, and then analyzed blood urea, kidney histopathology and gene expression in kidneys by QReal Time PCR. After 24 h of reperfusion, depletion of TCD4(+)CTLA4(+)Foxp3(+) cells reached 30.3%(spleen) and 67.8%(lymph nodes). 72 h after reperfusion depletion reached 43.1%(spleen) and 90.22%(lymph nodes) and depleted animals presented with significantly poorer renal function, while DTA-1(anti-GITR)-treated ones showed a significant protection, all compared to serum urea from control group (IgG: 150.10+/-50.04; PC61: 187.23+/-31.38; DTA-1: 64.53+/-25.65, mg/dL, p<0.05). These data were corroborated by histopathology. We observed an increase of HO-1 expression in animals treated with DTA-1 at 72 h of reperfusion with significant differences. Thus, our results suggest that PC61(anti-CD25) mAb treatment is deleterious, while DTA-1(anti-GITR) mAb treatment presents a protective role in the renal IRI, indicating that some regulatory populations of T cells might have a role in IRI.


Revista Da Sociedade Brasileira De Medicina Tropical | 2002

Características evolutivas do Cysticercus cellulosae no encéfalo e no coração humanos

Ruy de Souza Lino Junior; Patrícia M Ribeiro; Élida Juliana Antonelli; Ana Carolina Guimarães Faleiros; Sílvia A Terra; Marlene Antônia dos Reis; Vicente de Paula Antunes Teixeira

The present study aimed to evaluate the prevalence of cysticercosis, to classify the developmental phases of cysticerci found in human brains and hearts, and differentiate these according to the macro and microscopic aspects of the general pathological processes, and to compare the process found in the brains and hearts. Protocols from autopsies performed at the Hospital of the School of Medicine of the Triângulo Mineiro, Uberaba, MG, Brazil, in the period from 1970 to 2000 were reviewed. The prevalence of cysticercosis was verified in 71 cases, of which 53 (74.6%) were encephalic cysticercosis and 18 (25.3%) cardiac cysticercosis. Nineteen cysticerci were analyzed, from 9 brains and 10 hearts. The cysticerci were classified according to their developmental stage: vesicular, colloidal vesicular, granular nodular and calcified nodular, with similarities between the macroscopic and microscopic diagnoses. Among the pathological processes found beta-fibrilosis and endocardial fibroelastosis are underscored. In addition, it was demonstrated that this classification may be applied both to encephalic and cardiac cysticercosis.


Transactions of The Royal Society of Tropical Medicine and Hygiene | 1993

Possible role of an adrenal parasite reservoir in the pathogenesis of chronic Trypanosoma cruzi myocarditis

Vicente de Paula Antunes Teixeira; Maria Betânia Mahler Araújo; Marlene Antônia dos Reis; Lucelena dos Reis; Suzana Aparecida Silveira; Maria Laura Pinto Rodrigues; Joao Franquini

The possible contribution of parasitism of the central vein of the adrenal gland (CVAG) to chronic Trypanosoma cruzi myocarditis was assayed by comparing the occurrence of nests of amastigotes in the left ventricular myocardium (LVM) and determining the number and extent of areas of focal leucocyte exudate (FLE) in Chagas disease patients with and without CVAG parasitism. The frequency of occurrence of T. cruzi nests in the LVM, as well as the FLE number and area, were greater among patients with CVAG parasitism. We therefore suggest that CVAG parasitism plays a role in the onset and intensity of chronic T. cruzi myocarditis.


Revista Da Sociedade Brasileira De Medicina Tropical | 2004

Doenças infecciosas como causas de morte em idosos autopsiados

Flávia Aparecida de Oliveira; Marlene Antônia dos Reis; Eumenia Costa da Cunha Castro; Selma Freire de Carvalho da Cunha; Vicente de Paula Antunes Teixeira

The population aging in Brazil was associated with the alterations in the morbimortality of the population. The aim of this study was to verify the causes of death and other pathological processes in autopsied elderly. The elderly with 60 years or more in the period from 1976 to 1998 represented 394 cases (24.4%). The age median was 69 years ranged from 60 to 120 years, being higher in the women (70.5 versus 68 yrs;p<0.05). The male gender (67.5%), white color (69.8%), and the cardiovascular (43.7%) and infectious (31%) causes of death were dominate. In the malnourished (76.2%) it had association of pneumonia and cystitis, (p<0.05). Arteriosclerosis (61.9%), and the chagasic (42.1%) and hypertensive cardiopathies (39.1%) were the most frequent processes. Therefore, it was observed an overlapping of chronic-degenerative and infectious causes of death. This study shows the necessity to value of follow up of body mass index and of risk factors for the development of illness in aging patients like pneumonia.


Annals of Diagnostic Pathology | 2013

Role of mast cell chymase and tryptase in the progression of atherosclerosis: study in 44 autopsied cases.

Luciana Santos Ramalho; Lívia Ferreira Oliveira; Camila Lourencini Cavellani; Mara Lúcia Fonseca Ferraz; Flávia Aparecida de Oliveira; Rosana Rosa Miranda Corrêa; Vicente de Paula Antunes Teixeira; Sanívia Aparecida de Lima Pereira

The aim of this study was to describe the role of mast cell chymase and tryptase in the progression of atherosclerosis. Forty-four sections of aortas were obtained from autopsies. We assessed the macroscopic degree of atherosclerosis, microscopic intensity of lipid deposition in the tunica intima, percentage of collagen in the tunica intima, and density of immunostained mast cells. There was no significant difference between the density of mast cell tryptase and chymase concerning ethnicity, sex, cause of death, or degree of atherosclerosis. The density of mast cell chymase was significantly higher in the nonelderly group. The percentage of collagen was significantly higher in elderly patients. There was a positive and significant correlation between the degree of macroscopic atherosclerosis and lipidosis, the density of mast cell chymase and the percentage of collagen, the density of mast cell tryptase and the percentage of collagen, and lipidosis and the density of mast cell tryptase. The degree of macroscopic lesion of atherosclerosis increased proportionally with the increase in the density of mast cell chymase and tryptase and in the intensity of lipid deposition and with the percentage of collagen in the atherosclerotic plaques. Thus, mast cells may play a crucial role in aggravating atherosclerotic lesions.


Arquivos De Neuro-psiquiatria | 2007

Anatomopathological aspects of neurocysticercosis in autopsied patients

Ruy de Souza Lino-Júnior; Ana Carolina Guimarães Faleiros; Marina Clare Vinaud; Flávia Aparecida de Oliveira; Janaína Valadares Guimarães; Marlene Antônia dos Reis; Vicente de Paula Antunes Teixeira

The aim of this paper was to describe the occurrence and morphology of neurocysticercosis (NCC) in autopsies. We revised 2218 autopsies performed at the School Hospital from Federal University of Triangulo Mineiro, 1970-2003. Data referring to age, gender and color of patients were reported and NCC was microscopically and macroscopically analyzed. We found 53 (2.4%) NCC cases. The mean age was 50 years old, 34 (64.1%) individuals were male and 36 (67.9%) white. Macroscopically, 17 cysticerci were analyzed. The most frequent location was meningocortical in 12 (70.6%) cases. Microscopically, the cysticerci presented an ovoid shape, containing the larvae preserved in 4 (23.5%) cases or in destruction degrees in 13 (76.5%) cases. Therefore, in NCC was found several general pathologic processes (necrosis, interstitial deposits, fibrosis, gliosis, inflammation) amongst which are highlighted beta-fibrillose in 13 (76.5%) cases associated to inflammatory process in 16 (94.1%) cases caused by the parasite, not yet related to NCC, and calcification present in viable and destruction parasites.


Pathology Research and Practice | 2002

Pathologic findings in the adrenal glands of autopsied patients with acquired immunodeficiency syndrome.

Denise Bertulucci Rocha Rodrigues; Marlene Antônia dos Reis; Vicente de Paula Antunes Teixeira; Mario León Silva-Vergara; Dalmo Correia Filho; Sheila Jorge Adad; Javier Lazo

A morphologic evaluation was carried out on adrenal glands from 128 autopsied patients with the acquired immunodeficiency syndrome (AIDS). The adrenal gland was compromised in 99.2% of the cases, with distinct pathological features and infectious agents. Inflammatory infiltrates were observed in 99.2% of the cases with a predominance of mononuclear cells in 97.4%, affecting mainly the medulla. Necrosis, fibrosis, hemorrhages and neoplasias were observed. We also described 3 (2.3%) cases of calcification located in the adrenal gland central vein (AGCV). This is seldom mentioned in the literature. Cytomegalovirus was the most frequent infectious agent, observed in 48.4% of cases. Balamuthia mandrillaris, a free living ameba, was found in one case affecting the entire gland. We also found a nest of Trypanosoma cruzi in the musculature of the AGCV. The presence of the nest of T cruzi in AGCV may play a role in the reactivation of this infection in immunosuppressed individuals. Pathologic processes and opportunistic infections may contribute to the alterations in the adrenal gland that lead to multiple organ failure observed in terminal AIDS patients.


Revista Da Sociedade Brasileira De Medicina Tropical | 2000

Acidente humano por picadas de abelhas africanizadas

Flávia Aparecida de Oliveira; Janaína Valadares Guimarães; Marlene Antônia dos Reis; Vicente de Paula Antunes Teixeira

It is report five cases of stings of africanized bees (AB). Four of them were vitims of multiple stings, varying from 25 to 60, that presented severe headache, nauseas and vomits, related to the clinic effect of the toxicity of the venom, with good evolution. The other case was victim of a single sting of AB and died after probable anaphylaxis.

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