Vicente Martín Sánchez

0058 Colorectal cancer risk and shift work in a population-based case-control study in Spain (MCC-Spain)

Objectives Epidemiological cancer studies on shift work have focused on breast cancer while evidence on other tumours is limited. We evaluated colorectal cancer risk in relation to night and rotating shift work and genetic variation, in a population based case-control study in Spain. Method 1066 male and 592 female incident colorectal cancer cases and 3388 randomly selected population controls of both sexes, enrolled in 11 regions of Spain, were included. Information was collected on socio-demographic, lifestyle, medical history and other variables by face-to-face interviews. Lifetime occupational history on daily time schedule of each job, day/night/rotating shifts, light at night exposure, and duration of different jobs, was used for exposure assessment. We used unconditional logistic regression adjusting for potential confounders. Results Among controls 10% of males and 4% females had ever worked full time in permanent night shifts (working between midnight and 6am) and 24% of males and 14% of females in rotating shifts for ≥1 year. Having ever performed rotating shift work was associated with an increased risk for colorectal cancer (adjusted Odds Ratio 1.33, 95% CI 1.15–1.55) compared to permanent day workers. ORs increased with cumulative years of rotating shift work and the OR for more than 30 years work 1.54 (1.22–1.94). Having ever worked in permanent night shift was not associated with colorectal cancer risk. Analysis on gene-environment interactions with genes in circadian, melatonin and sleep pathways are ongoing and will be presented. Conclusions In this large population based study we found an increase in colorectal cancer risk associated with rotating shift work.

Night shift work and stomach cancer risk in the MCC-Spain study

Objectives Night shift work has been classified as a probable human carcinogen by the International Agency for Research on Cancer, based on experimental studies and limited evidence on human breast cancer risk. Evidence at other cancer sites is scarce. We evaluated the association between night shift work and stomach cancer risk in a population-based case–control study. Methods A total of 374 incident stomach adenocarcinoma cases and 2481 population controls were included from the MCC-Spain study. Detailed data on lifetime night shift work were collected including permanent and rotating shifts, and their cumulative duration (years). Adjusted unconditional logistic regression models were used in analysis. Results A total of 25.7% of cases and 22.5% of controls reported ever being a night shift worker. There was a weak positive, non-significant association between ever having had worked for at least 1 year in permanent night shifts and stomach cancer risk compared to never having worked night shifts (OR=1.2, 95% CI 0.9 to 1.8). However, there was an inverse ‘U’ shaped relationship with cumulative duration of permanent night shifts, with the highest risk observed in the intermediate duration category (OR 10–20 years=2.0, 95% CI 1.1 to 3.6) (p for trend=0.19). There was no association with ever having had worked in rotating night shifts (OR=0.9, 95% CI 0.6 to 1.2) and no trend according to cumulative duration (p for trend=0.68). Conclusion We found no clear evidence concerning an association between night shift work and stomach cancer risk.

A success story: New rules and fewer injuries in traditional Leonese Wrestling (2006-2012)

Introduccion El objetivo de nuestro estudio es analizar la efectividad de un cambio de reglamento en la incidencia de lesiones de Lucha Leonesa. Material y metodos Estudio de cohorte retrospectivo (2006-2007) y prospectivo (2008-2012). La poblacion estudiada comprendio todos los luchadores masculinos de mas de 16 anos que participaron en las Ligas de Invierno en las temporadas del 2006-2012. Se recogieron datos sobre el numero, la localizacion y la severidad de las lesiones, clasificandolos segun su localizacion y su gravedad. Se calculo la incidencia de lesiones por combates y por caidas antes y despues del cambio de reglamento. La formula para calcular la efectividad fue: 1 – Riesgo Relativo. Resultados En las 7 temporadas, se registraron un total de 34 lesiones, 9 antes del cambio de reglamento y 25 despues. Desde la introduccion de las nuevas reglas en 2008 no se produjo ninguna lesion grave en los miembros superiores, mientras que antes del cambio de reglamento la incidencia de lesiones fue de 10,4 por cada 1000 combates y de 3,9 por cada 1000 caidas, siendo estadisticamente significativa (p= 0,002 y p=0,006). La efectividad de la reduccion de la incidencia de lesiones graves fue del 94% por combates y del 91% por caidas. Conclusiones Los resultados de este estudio confirman la importancia de un enfoque metodologico para la prevencion de lesiones; en este caso, los cambios de reglamento.Objective To analyse the effectiveness of a change in the rules on the incidence of injuries in traditional Leonese Wrestling (LW).

Original articleA success story: New rules and fewer injuries in traditional Leonese Wrestling (2006–2012)Una historia de éxito: nuevas reglas y menos lesiones en la Lucha Leonesa (2005-2012)

Introduccion El objetivo de nuestro estudio es analizar la efectividad de un cambio de reglamento en la incidencia de lesiones de Lucha Leonesa. Material y metodos Estudio de cohorte retrospectivo (2006-2007) y prospectivo (2008-2012). La poblacion estudiada comprendio todos los luchadores masculinos de mas de 16 anos que participaron en las Ligas de Invierno en las temporadas del 2006-2012. Se recogieron datos sobre el numero, la localizacion y la severidad de las lesiones, clasificandolos segun su localizacion y su gravedad. Se calculo la incidencia de lesiones por combates y por caidas antes y despues del cambio de reglamento. La formula para calcular la efectividad fue: 1 – Riesgo Relativo. Resultados En las 7 temporadas, se registraron un total de 34 lesiones, 9 antes del cambio de reglamento y 25 despues. Desde la introduccion de las nuevas reglas en 2008 no se produjo ninguna lesion grave en los miembros superiores, mientras que antes del cambio de reglamento la incidencia de lesiones fue de 10,4 por cada 1000 combates y de 3,9 por cada 1000 caidas, siendo estadisticamente significativa (p= 0,002 y p=0,006). La efectividad de la reduccion de la incidencia de lesiones graves fue del 94% por combates y del 91% por caidas. Conclusiones Los resultados de este estudio confirman la importancia de un enfoque metodologico para la prevencion de lesiones; en este caso, los cambios de reglamento.Objective To analyse the effectiveness of a change in the rules on the incidence of injuries in traditional Leonese Wrestling (LW).