Vicky Minderhout

Lecture-free biochemistry: A Process Oriented Guided Inquiry Approach.

Biochemistry courses at Seattle University have been taught exclusively using process oriented guided inquiry learning (POGIL) without any traditional lecture component since 1997. In these courses, students participate in a structured learning environment, which includes a preparatory assignment, an in‐class activity, and a follow‐up skill exercise. Instructor‐designed learning activities provide the content of the course while the cooperative learning structure provides the content‐free procedures that promote development of critical process skills needed for learning. This format enables students to initially explore a topic independently, work together in groups to construct and refine knowledge, and eventually develop deep understanding of the essential concepts. These stages of exploration and concept development form the foundation for application to high level biochemical problems. At the end of this course, most students report feeling confident in their knowledge of biochemistry and report substantial gains in independence, critical thinking, and respect for others.

Learning transferable skills in large lecture halls: Implementing a POGIL approach in biochemistry

As research‐based, active learning approaches become more common in biochemistry classrooms, the large lecture course remains the most challenging to transform. Here, we provide a case study demonstrating how process oriented guided inquiry learning (POGIL) can be implemented in a large class taught in a traditional lecture hall. Course structure and multiple strategies to support student learning and encourage engagement are described in detail. Therefore, this case study could act as a model for others wishing to transform their own courses from lecture to a more student‐centered format. Student feedback about the course format was overwhelmingly positive and preliminary assessment data demonstrated student learning gains in several important areas. BIOCHEMISTRY AND MOLECULAR BIOLOGY EDUCATION, 2012

Identification of Threshold Concepts for Biochemistry

This study describes an iterative process involving faculty and students to identify potential threshold concepts for biochemistry.

Uncovering students' incorrect ideas about foundational concepts for biochemistry

This paper presents preliminary data on how an assessment instrument with a unique structure can be used to identify common incorrect ideas from prior coursework at the beginning of a biochemistry course, and to determine whether these ideas have changed by the end of the course. The twenty-one multiple-choice items address seven different concepts, with a parallel structure for distractors across each set of items to capture consistent incorrect responses. For the current study, the instrument was administered as a pre-test and post-test in majors level biochemistry courses, and the results from two different groups are presented. These results indicated that students performed better on the post-test, resulting in positive mean gain scores for each concept. The structure of the instrument allows data analysis that helped uncover persistent incorrect ideas for some of the concepts, including bond energy and protein alpha helix structure, even after a semester of instruction in biochemistry. The persistent incorrect idea for the protein alpha helix structure uncovered by this assessment has not been reported before in the literature. These results confirm the need to use a robust diagnostic instrument to assess students’ understanding of basic concepts at the beginning of the semester, but also stress the need to assess students near the end of the course to gain insight on the effectiveness of instruction. Since each group of students is different, biochemistry instructors are encouraged to use the instrument to identify problems with their own students’ incoming ideas rather than rely on published results to inform instruction. In addition to providing assistance for instructors of biochemistry in planning targeted instructional interventions, we anticipate that data collected from this instrument can also be used to identify potential modifications for prerequisite courses.

Probing and improving student's understanding of protein α‐helix structure using targeted assessment and classroom interventions in collaboration with a faculty community of practice

The increasing availability of concept inventories and other assessment tools in the molecular life sciences provides instructors with myriad avenues to probe student understanding. For example, although molecular visualization is central to the study of biochemistry, a growing body of evidence suggests that students have substantial limitations in their ability to recognize and interpret basic features of biological macromolecules. In this study, a pre/posttest administered to students at diverse institutions nationwide revealed a robust incorrect idea about the location of the amino acid side chains in the protein α‐helix structure. Because this incorrect idea was present even after a semester of biochemistry instruction at a range of institutions, an intervention was necessary. A community of expert biochemistry instructors collaborated to design two active learning classroom activities that systematically examine α‐helix structure and function. Several participating faculty used one or both of the activities in their classrooms and some improvement of student understanding of this concept was observed. This study provides a model of how a community of instructors can work together using assessment data to inform targeted changes in instruction with the goal of improving student understanding of fundamental concepts.

Sustaining the development and implementation of student‐centered teaching nationally: The importance of a community of practice

Although the idea of using a workshop to educate potential users about a set of materials or techniques is not new, the workshops described here go beyond simple dissemination and create ongoing communities of practice that support widespread and sustained improvement in the biochemistry classroom. The degree to which pedagogical innovations improve student learning on a national level depends on how broadly they are disseminated and how they are implemented and sustained. Workshops can be effective in disseminating ideas and techniques, but they often fail to sustain implementation. This paper describes Core Collaborators Workshops (CCWs) that were specifically designed for biochemistry faculty to improve the quality of active learning materials, support faculty in transforming their classrooms, and disseminate these efforts nationally. This CCW model proved very effective to date as shown by the fact that, 8 months after the last CCW, all workshop participants reported using at least some of the instructional materials discussed during the workshop. In addition, participants remarked that the superior community building and direct mentoring available through the CCWs greatly increased their confidence in implementing this new curricular approach and has made them more likely to act as leaders themselves. BIOCHEMISTRY AND MOLECULAR BIOLOGY EDUCATION Vol. 39, No. 6, pp. 405–411, 2011

For Want of a Better Word: Unlocking Threshold Concepts in Natural Sciences with a Key from the Humanities?.

ABSTRACT The process of identifying threshold concepts invites experts to reflect on their discipline in a new way with the ultimate goal of improving learning and teaching. During a workshop to identify threshold concepts in biochemistry, we asked a group of natural scientists to explore ‘signification,’ a threshold concept from the humanities, as a mechanism to push them out of their comfort zones and recall how it feels to experience learning from a student’s perspective. In addition to accomplishing this goal, we subsequently realized that signification could also help us uncover and remedy ways in which use of scientific terminology impedes learning in biochemistry. Using the results of a survey of university teachers that aimed at refining a list of possible threshold concepts, we present three scenarios to illustrate the challenges that teachers and students encounter when attempting to cement a label (the signifier) and a concept (the signified) into a coherent sign. Based on these findings, we propose that teachers can better explore threshold concepts if they carefully consider the role terminology plays in learning and teaching. Thus we describe the ‘terminological canyon’ through which university teachers must journey in order to produce effective learning and teaching activities related to the threshold concepts. While the work described here pertains to biochemistry, we believe the process and findings can be generalized to a broad range of disciplines.

Small Changes: Using Assessment to Direct Instructional Practices in Large-Enrollment Biochemistry Courses

The use of assessment to inform instruction with the goal of improving learning in undergraduate biochemistry is detailed. Student performance related to three foundational concepts—hydrogen bonding, bond energy, and pKa—was analyzed. Results support the use of assessment data to inform instructional change, especially in large-enrollment classes.