Víctor Edmundo Valdespino-Castillo

Bone lipoma: case report and review

Bone lipomas are infrequently in the current dairy medical practice, those tumor represent 0.1% of all bone tumors. Aetiology is unknown and surgery is the best treatment. In this tumors is necessary to do a relation physical – radiological and histopatological and, in this way is necessary to known a prognosis about them tumors. The bone tumors do not develop symptoms in general, its tumor become evident when we ask for a TC or radiography near to some articulation with pain or other clinical signal. This tumors can miss diagnosticated with other bening bone tumors. We present this case because is anecdotical in a female patient 67 years old. (creativecommons.org/licenses/by-nc-nd/4.0/).

Increasing the Potential Targets and Molecularly Targeted Agent Combinations Against Cancer Cell Proliferation

At least four main groups of intracellular signaling pathways or submodules concur in the cell division and proliferation module: those for the control of the cell cycle, those for the metabolism programming, those for cytoskeleton remodeling, and those for DNA replication and repair. Precise signaling pathways that control cell proliferation module require the joint functional collaboration of signaling pathways of cell growth, cell survival, cell differentiation, intracellular senescence and death programs, and appropriate interaction with angiogenesis, cell micro-environment regulation and immunologic system modules. Seeking out actionable aberrations in cancer cells may now selectively targeted by drug compounds to optimize treatment efficacy and minimize toxicity. This critical review provides an overview of the use of the CDK4/6 inhibitors as the first cell cycle inhibitor that improve the outcomes of patients with HR+ breast cancer. Discusses the connection of different inhibitory agents to modify cell proliferation signaling pathways and sketches the potential use of other molecularly targeted agents in close relationship with proliferation signaling pathways carcinoma cells.