Victor Ginsberg

Therapeutic effect of aureomycin in pernicious anemia.

Conclusions Four patients with Addisonian pernicious anemia in relapse and one patient with nutritional macrocytic anemia were treated with aureomycin given orally, with definite although submaximal hematological improvement. A fifth patient with Addisonian pernicious anemia was treated with aureomycin given intravenously with no response. We are indebted to Mrs. Helen Jakubowski for performing the blood examinations.

THE URINARY EXCRETION TEST IN THE DIAGNOSIS OF ADDISONIAN PERNICIOUS ANEMIA

Excerpt Addisonian pernicious anemia is a deficiency disease resulting from the lack of a specific gastric secretion which is essential for the optimal absorption in the intestine of orally ingeste...

Effect of Citrovorum Factor in Pernicious Anemia.

Summary 1. Citrovorum factor, in amounts of 5 to 10 million units daily intramuscularly, has been shown to produce adequate hematologic and clinical response in 4 of 6 patients with Addisonian pernicious anemia, and a submaximal response in another. A 6th patient failed to respond altogether. 2. Local marrow instillation of citrovorum factor failed to produce enhanced maturation of megaloblasts in situ. 3. Citrovorum factor has been found to be more effective than pteroylglutamic acid in reversing aminopterin inhibition in patients with pernicious anemia.

Effects of modified human globin in normal human subjects.

Conclusions 1. The effects of both slow and relatively rapid infusion of modified human globin in 6 human subjects without renal disease were studied. No untoward effects of the infusion were noted. 2. No significant increase in urine flow over control flows was noted. There was no change in the clearances of PAH during the globin infusion as compared with the control levels. There was a slight increase in the rate of excretion of sodium during the globin infusion as compared with control levels in 2 of the 6 patients. 3. No alteration in sedimentation rate and agglutinability of red blood cells was noted as a result of the infusion of globin.