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Victor J. Hruby

Cornell University

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Publication

Featured researches published by Victor J. Hruby.

Science | 1968

4-Leucine-Oxytocin: Natriuretic, Diuretic, and Antivasopressin Polypeptide

W. Y. Chan; Victor J. Hruby; George Flouret; Vincent du Vigneaud

During water diuresis in anesthetized rats, 4-leucine-oxytocin increased the urine output and the rates of sodium and chloride excretion. The potassium excretion rate was only slightly increased. During vasopressin-suppressed water diuresis, 4-leucine-oxytocin produced similar effects on urine and electrolyte excretions. In addition, it inhibited the vasopressin-induced free-water reabsorption, and it could reverse reabsorption to freewater clearance.

Journal of the American Chemical Society | 1968

The structure of acetone-oxytocin with studies on the reaction of acetone with various peptides.

Victor J. Hruby; D Yamashiro; V. du Vigneaud

Canadian Journal of Physiology and Pharmacology | 1991

Effects of inactivation of oxytocin receptor and inhibition of prostaglandin synthesis on uterine oxytocin receptor and gap junction formation and labor in the rat

W. Y. Chan; Irene Berezin; E. E. Daniel; K. C. Russell; Victor J. Hruby

Journal of the American Chemical Society | 1970

The synthesis of [1-deamino,4-l-leucine]-oxytocin and [1-deamino,4-l-isoleucine]-oxytocin and some of their pharmacological properties

Herbert Takashima; Victor J. Hruby; Vincent du Vigneaud

Journal of the American Chemical Society | 1967

The preparation and properties of 1,2-bis(triphenylphosphoranyl)benzocyclobutene

Alfred T. Blomquist; Victor J. Hruby

Journal of Medicinal Chemistry | 1970

(2,4-Diisoleucine)-oxytocin. An analog of oxytocin with natriuretic and diuretic activities.

Victor J. Hruby; Vincent du Vigneaud; Wah-Yip. Chan

Journal of Biological Chemistry | 1969

The Synthesis and Some of the Pharmacological Properties of [4-L-Isoleucine]-oxytocin and [4-L-Leucine]-oxytocin

Victor J. Hruby; George Flouret; V. Du Vigneaud

Journal of the American Chemical Society | 1969

Detection of a Schiff base intermediate in the formation of acetone-oxytocin

Victor J. Hruby; Vincent Du Vigneuad

Journal of Medicinal Chemistry | 1969

Synthesis and some pharmacological activities of [2-L-valine]-oxytocin and [2-L-leucine]-oxytocin

Victor J. Hruby; Vincent du Vigneaud

Journal of Pharmacology and Experimental Therapeutics | 1974

Effects of magnesium ion and oxytocin inhibitors on the uterotonic activity of oxytocin and prostaglandins E2 and F2ALPHA.

W. Y. Chan; Victor J. Hruby; V. Du Vigneaud

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Vincent du Vigneaud

Cornell University

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W. Y. Chan

Cornell University

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Alfred T. Blomquist

Cornell University

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George Flouret

Cornell University

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Daniel H. Rich

University of Wisconsin-Madison

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E. E. Daniel

Cornell University

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Herbert Takashima

Cornell University

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Irene Berezin

Cornell University

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K. C. Russell

Cornell University

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L. A. Branda

Cornell University

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