Victoria J. Ganem

Low-dose ketamine vs morphine for acute pain in the ED: a randomized controlled trial☆ , ☆☆

OBJECTIVES To compare the maximum change in numeric rating scale (NRS) pain scores, in patients receiving low-dose ketamine (LDK) or morphine (MOR) for acute pain in the emergency department. METHODS We performed an institutional review board-approved, randomized, prospective, double-blinded trial at a tertiary, level 1 trauma center. A convenience sample of patients aged 18 to 59 years with acute abdominal, flank, low back, or extremity pain were enrolled. Subjects were consented and randomized to intravenous LDK (0.3mg/kg) or intravenous MOR (0.1mg/kg). Our primary outcome was the maximum change in NRS scores. A sample size of 20 subjects per group was calculated based on an 80% power to detect a 2-point change in NRS scores between treatment groups with estimated SDs of 2 and an α of .05, using a repeated-measures linear model. RESULTS Forty-five subjects were enrolled (MOR 21, LDK 24). Demographic variables and baseline NRS scores (7.1 vs 7.1) were similar. Ketamine was not superior to MOR in the maximum change of NRS pain scores, MOR=5 (confidence interval, 6.6-3.5) and LDK=4.9 (confidence interval, 5.8-4). The time to achieve maximum reduction in NRS pain scores was at 5 minutes for LDK and 100 minutes for MOR. Vital signs, adverse events, provider, and nurse satisfaction scores were similar between groups. CONCLUSION Low-dose ketamine did not produce a greater reduction in NRS pain scores compared with MOR for acute pain in the emergency department. However, LDK induced a significant analgesic effect within 5 minutes and provided a moderate reduction in pain for 2 hours.

Aeromedical evacuation of combat patients by military critical care air transport teams with a lower hemoglobin threshold approach is safe.

BACKGROUND Military critical care air transport teams (CCATT) evacuate critically ill and injured patients out of theater for tertiary treatment. Teams are led by a physician, nurse, and respiratory technician. Current aeromedical guidelines require a hemoglobin (Hgb) of 9 g/dL or greater to evacuate; however, civilians report that an Hgb of 8 g/dL or less is safe in critically ill patients. This study aimed to compare postflight short-term and 30-day patient outcomes for CCATT patients evacuated out of theater with an Hgb of 8 g/dL or less with those with an Hgb of greater than 8 g/dL. METHODS We conducted a retrospective record review of all traumatically injured patients evacuated from theater by CCATT between March 2007 and December 2011. We recorded demographics, injury descriptions, vital signs, laboratory values, adverse events, and disposition at 30 days. Patients were separated into those with a preflight Hgb of 8 g/dL or less versus those with greater than 8 g/dL. Continuous data were analyzed using Student’s t tests or Wilcoxon tests and reported as mean ± SD. &khgr;2 or Fisher’s exact tests were performed. Stepwise, multifactorial logistic regression models were used. Statistical significance was considered with p < 0.05. RESULTS Of 1,252 patients, 1,033 had a preflight Hgb of greater than 8 and 219 had an Hgb of 8 or less. Age, sex proportions, vitals, laboratory values, and Injury Severity Score (ISS; 24±13) were similar. The group with 8 or less had more blast injuries (68% vs. 76%, p = 0.01). No associations were identified between preflight Hgb levels and adverse outcomes. Disposition at 30 days was similar. We also compared preflight Hgb greater than 7 versus 7 or less (n = 1,212 vs. 45). Those with an Hgb greater than 7 had a greater incidence of hospitalization at 30 days (77% vs. 67%, p = 0.04). The group with an Hgb of 7 or less had more subjects discharged home or returning to duty (10% vs. 21%, p = 0.04). CONCLUSION Evacuating CCATT patients with an Hgb of 8 or less had similar adverse outcomes and mortality at 30 days compared with those with an Hgb greater than 8. Patients with an Hgb of 7 or less had higher rates of hospital discharge and decreased incidence of hospitalization at 30 days. LEVEL OF EVIDENCE Prognostic/epidemiologic study, level III.

Misuse of prescribed pain medication in a military population: a self-reported survey to assess a correlation with age, deployment, combat illnesses, or injury?

Opioid misuse is a growing epidemic among the civilian and military communities. Five hundred prospective, anonymous surveys were collected in the emergency department waiting room of a military tertiary care hospital over 3 weeks. Demographics, medical and military characteristics were investigated for association with opioid use. Univariate logistic models were used to characterize the probability of misuse in relation to the demographic, medical, and military-specific variables. Traumatic brain injury (TBI) and posttraumatic stress disorder were investigated within different age cohorts with adjustment for deployment. The opioid misuse rate disclosed by the subject was 31%. Subjects with TBI were less likely to misuse opioids. We found a trend among younger cohorts to have a higher likelihood for misusing opioids when diagnosed with TBI or posttraumatic stress disorder with history of deployment in the past 5 years. The most common form of misuse was using a previously prescribed medication for a new pain. Traumatic brain injury and/or enrollment in post-deployment recovery programs maybe protective against opioid misuse. Chronic opioid use among young soldiers maybe viewed as a weakness that could influence opioid misuse. Younger cohorts of active duty service members could be at higher risk for misuse. Efforts to enhance close monitoring of misuse should address these at-risk populations.

Emergency medicine providers' opioid prescribing practices stratified by gender, age, and years in practice

BACKGROUND Emergency medicine providers (EMPs) prescribe about 25% of opioids, but the effect of EMP risk perception on decisions to prescribe opioids is unknown. This study was undertaken to identify factors that influence EMP risk and opioid prescribing practices. METHODS We distributed an anonymous questionnaire to EMPs at a military trauma and referral center. Response frequencies and distributions were assessed for independence using the Chi-square test. RESULTS Eighty-nine EMPs completed the questionnaire (100% response). Respondents were primarily younger male physicians (80%) in practice under five years (55%). Male EMPs were more likely to prescribe more opioid tablets than female ones both when and when not concerned for opioid misuse (P<0.001, P<0.007, respectively). Of the providers, 70% stated that patient age would influence their prescribing decisions. Hydrocodone and oxycodone were the opioids prescribed most frequently. About 60% of the providers reported changing their prescribing behavior would not prevent opioid misuse. Additionally, 40% of the providers believed at least 10% of patients seen at this military ED misused opioids. CONCLUSION Female EM providers reported prescribing fewer opioid tablets. Patient age influenced prescribing behavior, but the effect is unknown. Finally, EM providers reported that altering their prescribing behavior would not prevent prescription opioid misuse.

Navy En Route Care: A 3-Year Review of 428 Navy Air Evacuations

BACKGROUND Navy medical personnel have been recording en route care (ERC) missions through Search and Rescue (SAR) reports since the 1970s. Our objective was to report clinical ERC cases treated by Navy operational assets from January 2012 to January 2015. METHODS The Search and Rescue Model Manager office collects SAR reports for all patient transports involving Navy personnel and equipment. From these reports, descriptive statistics to include total number of patients transported, percentages of Advanced Life Support versus Basic Life Support transports, time of transport, and type of ERC provider for the transport were collected. Data reported as median (interquartile range) or percentages. RESULTS During a 3-year period, 428 patients were transported. Transport time was 54 (30-78) minutes. Missions were staffed by more than one provider 22% of the time. Individual providers included 76% Search and Rescue Medical Technicians, 25% Flight Surgeons, and 21% Other. Patients required ALS transport 54% of the time. Less than half (48%) of the patients were trauma related. CONCLUSION In our review of 428 SAR reports from Navy ERC (2012-2015), we found that 76% of the missions were performed by Search and Rescue Medical Technicians and 54% met Advanced Life Support transport criteria.

En Route Use of Analgesics in Nonintubated, Critically Ill Patients Transported by U.S. Air Force Critical Care Air Transport Teams

INTRODUCTION U.S. Critical Care Air Transport Teams (CCATTs) evacuate critically ill patients with acute pain in the combat setting. Limited data have been reported on analgesic administration en route, and no study has reported analgesic use by CCATTs. Our objective was to describe analgesics used by CCATTs for nonintubated, critically ill patients during evacuation from a combat setting. METHODS We conducted an institutional review board-approved, retrospective review of CCATT records. We included nonintubated, critically ill patients who were administered analgesics in flight and were evacuated out of theater (2007-2012). Demographics, injury description, analgesics and anesthetics, and predefined clinical adverse events were recorded. Data were presented as mean ± standard deviation or percentage (%). RESULTS Of 1,128 records, we analyzed 381 subjects with the following characteristics: age 26 ± 7.0 years; 98% male; and 97% trauma (70% blast, 17% penetrating, 11% blunt, and 3% burn). The injury severity score was 19 ± 9. Fifty-one percent received morphine, 39% hydromorphone, 15% fentanyl, and 5% ketamine. Routes of delivery were 63% patient-controlled analgesia (PCA), 32% bolus intravenous (IV) administration, 24% epidural delivery, 21% continuous IV infusions, and 9% oral opioids. Patients that were administered local anesthetics (nerve block or epidural delivery) with IV opioids received a lower total dose of opioids than those who received opioids alone. No differences were associated between analgesics and frequency of complications in flight or postflight. CONCLUSION About half of nonintubated, critically ill subjects evacuated out of combat by CCATT received morphine and more than half had a PCA. In our study, ketamine was not frequently used and pain scores were rarely recorded. However, we detected an opioid-sparing effect associated with local anesthetics (regional nerve blocks and epidural delivery).

Prescription stimulant misuse in a military population

BACKGROUND Increased prescription drug misuse has been reported in veterans, yet there has not been a focused look at stimulant misuse in the military community or correlation with deployment injuries and illnesses. Our objective was to identify rates of stimulant misuse and any correlation with deployment in the military population. METHODS A prospective, anonymous institutional review board-approved survey in the emergency department waiting room of a military tertiary care hospital using a 12-item questionnaire created with fixed response and multiple-choice questions. Stimulant misuse was defined as taking more than prescribed, obtaining stimulants from others, and taking it for a nonprescribed reason. Proportions were assessed by Chi-square test and Fishers exact test. RESULTS 26/498 (5%) of respondents reported misusing stimulants in the last 5 years. Misusers were more likely to have a mental health diagnosis, and they suffered either a deployment-related injury or another injury, as compared to those who used stimulants properly (p<0.05). The stimulant misuse did not correlate with age, gender, active duty status, education, location of deployment, number of times deployed, traumatic brain injury diagnosis, or enlistment status. CONCLUSION Stimulant drug misuse in the military community is associated with mental health conditions, deployment-related injuries, or new physical injuries.

A 3-Year Comparison of Overdoses Treated in a Military Emergency Department—Complications, Admission Rates, and Health Care Resources Consumed

BACKGROUND Drug overdose has become a leading cause of death in the United States and is a growing issue in civilian and military populations. Increasing prescription drug misuse and poisonings translate into greater utilization of medical resources. Our objective was to describe the incidences of overdoses and their associated events and outcomes following emergency department consult. METHODS We performed a retrospective cohort study on cases evaluated in 2 military hospital emergency departments over 3 years. Subjects were identified using International Classification of Diseases, 9th Revision codes 960-970. Variables collected included demographics, military service, method of arrival, vital signs, clinical complications, and hospital admission, if overdose was documented as intentional or unintentional and drug ingested. RESULTS Over 3 years, 342 overdoses were treated. Mean age was 35 ± 19 and gender was 53% female. 47% were active duty and 32% were dependents. 21% of overdoses involved benzodiazepines and 20% opioids. Active duty and benzodiazepine overdoses were more likely to arrive by ambulance (p = 0.0006, p = 0.03), were more likely to have overdosed intentionally (p = 0.02, p = 0.009), and were more likely to be admitted (p = 0.04, p = 0.007). Active duty had a longer length of stay (p = 0.02). CONCLUSION Overdoses involving the active duty population and benzodiazepines consume greater military health care resources than other overdoses.