Vincent Chaleix
University of Limoges
Network
Latest external collaboration on country level. Dive into details by clicking on the dots.
Publication
Featured researches published by Vincent Chaleix.
Journal of Materials Chemistry B | 2015
Chiara Mauriello-Jimenez; Jonas G. Croissant; Marie Maynadier; Xavier Cattoën; Michel Wong Chi Man; Julien Vergnaud; Vincent Chaleix; Vincent Sol; Marcel Garcia; Magali Gary-Bobo; Laurence Raehm; Jean-Olivier Durand
The synthesis of a zinc porphyrin derivative possessing eight triethoxysilyl groups was performed through a CuAAC-click reaction. This porphyrin was covalently entrapped in ethenylene-bridged mesoporous organosilica nanoparticles which efficiently allowed performing doxorubicin delivery and two-photon imaging of breast cancer cells.
Carbohydrate Polymers | 2013
Jean-Pierre Mbakidi; Klara Herke; Sandra Alves; Vincent Chaleix; Robert Granet; Pierre Krausz; Stéphanie Leroy-Lhez; Tan-Sothea Ouk; Vincent Sol
We report on the synthesis of cellulose paper bearing a cationic porphyrin, designed for antimicrobial applications. Tricationic porphyrin has been covalently grafted on paper, without previous chemical modification of the cellulosic support, using 1,3,5-triazine derivative as linker. The obtained porphyrin-grafted paper was characterized by infrared (ATR-FTIR), UV-visible and diffuse reflectance UV-vis (DRUV) spectroscopies to confirm the triazine linkage. Thermogravimetric analysis (TGA) was used to investigate thermal properties of grafted paper. Antimicrobial activity of porphyrin-cellulose material was tested under visible light irradiation against Staphylococcus aureus and Escherichia coli. The two bacterial strains deposited on the resulting photosensitizing filter paper are efficiently killed after illumination.
Bioorganic & Medicinal Chemistry Letters | 2016
Gautier Mark Arthur Ndong Ntoutoume; Robert Granet; Jean-Pierre Mbakidi; Frédérique Brégier; David Y. Leger; Chloë Fidanzi-Dugas; Vincent Lequart; Nicolas Joly; Bertrand Liagre; Vincent Chaleix; Vincent Sol
The synthesis of curcumin-cyclodextrin/cellulose nanocrystals (CNCx) nano complexes was performed. CNCx were functionalized by ionic association with cationic β-cyclodextrin (CD) and CD/CNCx complexes were used to encapsulate curcumin. Preliminary in vitro results showed that the resulting curcumin-CD/CNCx complexes exerted antiproliferative effect on colorectal and prostatic cancer cell lines, with IC50s lower than that of curcumin alone.
Bioorganic & Medicinal Chemistry Letters | 2016
Shihong Qiu; Robert Granet; Jean-Pierre Mbakidi; Frédérique Brégier; Christelle Pouget; Ludovic Micallef; Tan Sothea-Ouk; David Y. Leger; Bertrand Liagre; Vincent Chaleix; Vincent Sol
A new anti-cancer drug delivery system, based on gold nanoparticles, has been designed for hydrophobic active compounds. The system is a conjugate of gold/polyethyleneimine (AuNPs/PEI) nanoparticles and sulphated β-cyclodextrin (CD). Anionic cyclodextrin was attached to the positively charged AuNPs/PEI nanoparticles by ionic bonds. Tanshinone IIA and α-mangostin were extracted, purified and encapsulated into the AuNPs/PEI/CD nanoparticles. In vitro preliminary cell viability assays against prostate cancer cell lines PC-3 and DU145 showed that encapsulation resulted in increased cytotoxicity.
Planta Medica | 2014
Amandine Dieu; Marion Millot; Yves Champavier; L Mambu; Vincent Chaleix; Vincent Sol; Vincent Gloaguen
Bioassay-guided fractionation of an extract of the lichen Cladonia incrassata against Staphylococcus aureus led to a novel compound, 1,5-dihydroxy-2,4,6-trichloro-7-methylxanthone (1), along with six known compounds: (-)-usnic acid (2), didymic acid (3), condidymic acid (4), squamatic acid (5), thamnolic acid (6), and prasinic acid (7). Didymic, condidymic, and prasinic acids were isolated for the first time from C. incrassata. Didymic, condidymic, and (-)-usnic acids were active against S. aureus (a minimum inhibitory concentration of 7.5 µg/mL).
Analytical Methods | 2014
E. Poli; Vincent Chaleix; C. Damia; Z. Hjezi; Eric Champion; Vincent Sol
Enhancement of osteogenic properties of bone substitutes is best achieved by the covalent attachment of appropriate biomolecules, e.g. proteins and peptides, on amino-functionalized implant materials. Measurement of the free amino surface density of these materials is mandatory before derivatization. Two photometric methods were developed to assay the free amino groups of organosilane molecules covalently grafted onto hydroxyapatite and silicon-substituted hydroxyapatite ceramic surfaces. Reaction of amino-derivatized apatites with ninhydrin led to the formation of Ruhemanns purple quantified by the absorbance at 586 nm. Alternatively, ceramics were reacted with Fmoc-derivatized amino acids in the presence of piperidine, leading to the dibenzofulvene–piperidine adduct measured at 301 nm. Both methods allow the detection of free amino groups down to 1.0 × 10−8 mol g−1 of apatite-ceramics and, since they are conducted under non-acid conditions, preserve the acid-sensitive structure of hydroxyapatite.
Nucleosides, Nucleotides & Nucleic Acids | 2008
Amel Hadj-Bouazza; Karine Teste; Ludovic Colombeau; Vincent Chaleix; Rachida Zerrouki; Michel Kraemer; Odile Sainte Catherine
The synthesis and biological activity of a novel DNA cross-linking antitumor agent is presented. The new alkylating agent significantly inhibited cell proliferation, migration and invasion as tested in vitro on the A431 vulvar epidermal carcinoma cell line.
International Journal of Biological Macromolecules | 2014
Emmanuel Renault; Aline Barbat-Rogeon; Vincent Chaleix; Claude-Alain Calliste; Cyril Colas; Vincent Gloaguen
4-O-Methylglucuronoxylans (MGX) were isolated from chestnut wood sawdust using two different procedures: chlorite delignification followed by the classical alkaline extraction step, and an unusual green chemistry process of delignification using phthalocyanine/H2O2 followed by a simple extraction with hot water. Antioxidant properties of both MGX were evaluated against the stable radical 2,2-diphenyl-1-picrylhydrazyl (DPPH) by electronic spin resonance (ESR). IC50 of water-extracted MGX was found to be less than 225 μg mL(-1), in contrast with alkali-extracted MGX for which no radical scavenging was observed. Characterization of extracts by colorimetric assay, GC, LC-MS and NMR spectroscopy provided some clues to understanding structure-function relationships of MGX in connection with their antioxidant activity.
Water Air and Soil Pollution | 2012
Kadda Hachem; Cédric Astier; Vincent Chaleix; Céline Faugeron; Pierre Krausz; Meriem Kaid-Harche; Vincent Gloaguen
The polysaccharidic moieties of three biosorbents (Douglas fir and argan tree barks and argan endocarp) were selectively oxidized, and the subsequent modified materials were tested for their ability to bind Pb(II) or Cd(II) from aqueous solutions. Chemical modifications consisted in two selective oxidations, alone or in combination, of the following groups: primary alcohols with NaOBr catalyzed by (2,2,6,6-tetramethylpiperidin-1-yl)oxidanyl, and vicinal diols with periodate/chlorite. The sodium chlorite oxidation step induced biosorbent degradation that led to a significant decrease of mass yield. Modified materials, characterized by FT-IR spectroscopy and measurement of surface acidity, were investigated for their adsorption capabilities of Cd(II) and Pb(II). Results were compared to the capabilities of crude materials using the Langmuir adsorption model in terms of affinity (b) and maximum binding capacity (qmax). Ion exchange properties were found better for lead than for cadmium before and after chemical modifications. Compared to crude barks, the best results were obtained for Douglas fir barks whose oxidation resulted in significant enhancements of qmax up to × 10 in the case of lead.
Journal of Porphyrins and Phthalocyanines | 2009
Vincent Chaleix; Pierre Couleaud; Vincent Sol; Rachida Zerrouki; Sandra Alves; Pierre Krausz
A mild method for O-alkylation of meso-hydroxyphenylporphyrin has been developed using microwave irradiation. This method is clean and efficient for many substrates and results in significant improvement in reaction yield and in a dramatic decrease in reaction time in comparison to thermal heating.