Vincent Groupé

Observations on Antiviral Activity of Viscosin.

Summary Viscosin was found to exert a marked protective effect in embryonated eggs subsequently infected with infectious bronchitis virus. A slight but detectable suppressive effect on the progress of infection in mice infected with influenza A virus was demonstrated.

Surface striations of Euglena gracilis revealed by electron microscopy.

Summary A regular pattern of groovelike striations was observed on the pellicle of Euglena gracilis.

Suppression of Viral Pneumonia in Mice by a Microbial Product (APM)

Summary A material (APM) produced by a culture of Achromobacter sp., was found to possess a unique combination of biological characteristics, (a) APM was not inhibitory to representative species of bacteria or fungi in vitro, (b) Preparations capable of suppressing the development of pulmonary lesions in mice previously infected with influenza A virus were found to be devoid of virucidal activity in vitro and failed to affect the production of infectious virus in lung tissue or allantoic fluid. (c) The mouse was a far better host than the embryonated egg for the demonstration or detection of inhibitory effects of APM on influenza A virus. (d) Hemagglutination in vitro by influenza A or B virus was not affected by the presence of APM. (e) The most interesting characteristic of APM was its capacity to suppress the development of non-transmissible pneumonia in mice induced by intranasal inoculation of Newcastle disease virus.

Electron micrographs of the elementary bodies of fowl pox and canary pox.

Summary The elementary bodies of fowl pox closely resemble those of canary pox and have many morphological characteristics in common with the elementary bodies of vaccinia.

Electron Micrographs of the Agent of Feline Pneumonitis (Baker)

Summary Electron microscope studies of the agent of feline pneumonitis suggest that the elementary bodies in nature have properties similar to those of jelly-filled sacs which in course of preparation for examination in the microscope settle to a form similar to a wrinkled pea with one flattened side. Such distorted bodies are approximate- 465 μ in diameter. They have several characteristics which resemble rickettsiae and bacteria.

Isolation of an Agent in Chicken Embryo Causing Infectious Sinusitis of Turkeys

Summary An agent capable of producing clinical sinusitis in turkeys was isolated and propagated in the yolk sac of the developing chicken embryo. 2. Impression smears of infected yolk sacs stained by Machiavellos technic revealed morphologic forms closely resembling those found in the lymphogranuloma-psittaeosis group of agents (Chlamydozoaceae).

Effect of atabrine on Tetrahymena geleii (Protozoa, Ciliata).

Summary Multiplication of Tetrahymena geleii was inhibited by 50 y of atabrine per ml. Resistance of the cells to atabrine was progressively decreased by the environmental changes occurring during growth of the culture and was strikingly decreased when the pH of the culture was increased.

Studies on Toxicity Complement-Fixing and Immunogenic Activity of Typhus-Infected Yolk Sacs

Summary Under the conditions described, the toxicity of untreated yolk suspensions and the antigenicity of typhus vaccines prepared from embryos harvested on consecutive days rose together with the complement-fixing activity of the same antigens.

Auto-interference associated with influenza B virus.

Summary Experiments are described illustrating (a) the use of death of the embryo as a criterion for the measurement of infectivity and interference, (b) an increase in the amount of interfering material present in allantoic fluid following death of the embryo and (c) the absence of demonstrable auto-interference following inoculation into the yolk sac.

On the Specificity of Epidemic and Murine Typhus.

The specificity of epidemic and murine typhus has been shown by active immunization of mice with killed rickettsial suspensions and subsequent challenge with heterologous and homologoustoxic substance. During the preparation of this manuscript, Fitzpatrick published findings showing that 3 of 8 mice immunized with murine typhus vaccine were protected against 3 MLD of epidemic toxic substance administered intravenously and that 8 of 16 mice immunized with epidemic vaccine were protected against < 1 MLD of murine typhus rickettsiae administered intraperitoneally (2). These results suggested to Fitzpatrick that the toxic factor in the two strains is identical. Although there are antigens common to both strains, our findings do not support the suggestion that the two toxic substances are identical.