Vinod F. Patel

Novel trityl linked drug immunoconjugates for cancer therapy

Abstract Trityl linkers were utilized in the preparation of acid labile nucleoside monoclonal antibody conjugates, COL1-N6-Trityl-207702 (1a-f). Conjugation led to high levels of drug incorporation into the MoAb with retention of good immunoreactivity. A strong correlation was found between the cytotoxicity of the constructs and substituents R and R′ on the aromatic rings of the trityl linker.

Tritylated oncolytics as prodrugs

Abstract A series of tritylated difluorodeoxynucleosides represent novel prodrugs in which there exists a predictable correlation between the electronic nature of the aromatic substituents on the trityl moiety and the acid mediated dissociation to free drug in ex vivo, in vitro and in vivo systems.