Vinod Mokale

Formulation of metformin hydrochloride nanoparticles by using spray drying technique and in vitro evaluation of sustained release with 32-level factorial design approach

ABSTRACT The aim of this study was to investigate the combined influence of two independent variables in the preparation of sustained release metformin hydrochloride (MH) nanoparticles by 32-factorial design using a spray drying method. Polymer concentration and amount of organic solvent are selected as independent variables while drug loading and drug release were considered as dependent variables. The nanoparticles were characterized using particle size analyzer, which is obtained in the range of 400–700 nm, Fourier transform infrared spectroscopy, and X-ray diffraction. The kinetics of the dissolution process was studied by analyzing the dissolution data. The results suggested that MH nanoparticles are suitable for sustained release of drug.

Synthesis and Pharmacological Evaluation of Novel 1-(2-(Benzoyl-Substituted-2-phenyl-1H-Indol-5-Carbony) Hydrazinyloxy) Vinyl Nitrate Derivatives as Potent Non-Ulcerogenic, Analgesic and Anti-Inflammatory Agents

Six derivatives of 1-(2-(benzoyl-(substituted)-2-phenyl-1H-indole-5-carbony) hydrazinyloxy) vinyl nitrate were synthesized and tested in vivo for anti-inflammatory, analgesic, and ulcerogenic properties. Synthesized compounds shown significant anti-inflammatory activity comparable to that of Diclofenac sodium in the carrageenan-induced rat paw edema test and all of the compounds were found to be equipotent to Diclofenac sodium in the acetic acid induced writhing analgesic model. Out of six derivatives two derivatives found to produce no ulceration in stomach specimen of rats; nitric oxide seems to contribute to their excellent safety profile which supports several endogenous GIT defense mechanisms, including increase in mucus, bicarbonate secretions, increase in mucosal blood flow, and inhibition of the activation of pro-inflammatory cells by which NO-Indomethacin protects GI mucosa.