Vipin Sam Alexander
Christian Medical College & Hospital
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Featured researches published by Vipin Sam Alexander.
CHRISMED Journal of Health and Research | 2014
Atul Kumar; Aroma Oberoi; Vipin Sam Alexander
Background: Shigella is an important cause of invasive dysentery in children and others. The present study was done to study the prevalence, any seasonal variation, distribution among children and adults, and antimicrobial susceptibility pattern of Shigella isolates in stool. Materials and Methods: A retrospective study was conducted over a period of 1 year from June 2011 to June 2012 in the department of microbiology, in a tertiary care hospital in Punjab. Stool specimens from diarrhea/dysentery cases in different age-groups were processed. The specimens were processed by standard microbiological techniques. The suspected colonies of Shigella were identified by standard biochemical tests and serotyping was done by group specific antisera. The susceptibility of all the isolated Shigella species to different antibiotics were done by Kirby-Bauer′s disk diffusion technique as per the Clinical and Laboratory Standards Institute (CLSI) guidelines. Results: Shigella species were isolated from 30 (2.1%) of the total 1,402 stool samples received during the study period. Among these, Shigella flexneri was the predominant species accounting for 57% of isolates, followed by S. sonnei (36%) and S. boydii (7%). Over 70% of Shigella isolates were resistant to two or more drugs including ampicillin, trimethoprim-sulfamethoxazole, and norfloxacin; and 10% Shigella isolates were resistant to chloramphenicol and ceftriaxone during the study period. No resistance was observed to cefoperazone/sulbactam, piperacillin/tazobactam, and imipenem. Conclusions: The results of the study revealed the high prevalence of shigellosis with S. flexneri as the predominant species. The result also suggests that ampicillin, trimethoprim-sulfamethoxazole and norfloxacin should not be used empirically as the first line drugs in the treatment of shigellosis. Periodic analysis and reporting of antibiotic susceptibility is an important measure to check for antibiotic resistance and form appropriate treatment protocols.
CHRISMED Journal of Health and Research | 2016
Anuniti Mathias; Aroma Oberoi; Mary John; Vipin Sam Alexander
Aim: This study was done to determine the minimum inhibitory concentration (MIC) of imipenem for multidrug-resistant (MDR) clinical isolates and identify carbapenemase-producing organisms among these MDR isolates. Materials and Methods: The antibiotic susceptibility of clinical isolates was determined by Kirby–Bauer disc diffusion method. MDR isolates showing resistance or reduced susceptibility to carbapenems were further tested for MIC with imipenem and carbapenemase production by Modified Hodge test (MHT). Results: A total of 65 MDR isolates were tested, of which 46 (70.77%), 15 (23%), and 4 (6.15%) had MIC in resistant, sensitive, and intermediate range, respectively. MHT was positive for 37 (57%) isolates. The most common carbapenemase producers in order of frequency were Acinetobacter baumannii, Klebsiella pneumoniae, Enterobacter aerogenes, Escherichia coli, Pseudomonas spp. Conclusion: Phenotypic tests such as MHT are simple, cost-effective, and easy to perform and hence can be used in any microbiology laboratory to detect carbapenemase production and applied clinically to guide the antimicrobial therapy, especially in severe and life-threatening infections.
International Journal of Basic and Applied Sciences | 2013
Ekta Mala; Aroma Oberoi; Vipin Sam Alexander
PNEUMOCYSTIS JIROVECII PNEUMONIA: PREVALENCE IN HOSPITALISED PATIENTS, A STUDY CONDUCTED IN A TERTIARY CENTRE IN PUNJAB. | 2016
Dilip Abraham; Aroma Oberoi; Eshani Dewan; Vipin Sam Alexander
Journal of Evolution of medical and Dental Sciences | 2016
Vipin Sam Alexander; Aroma Oberoi; Atul Kumar
Journal of Evolution of medical and Dental Sciences | 2016
Dilip Abraham; Aroma Oberoi; Eshani Dewan; Vipin Sam Alexander
COMPARATIVE ACTIVITY OF DORIPENEM, IMIPENEM AND MEROPENEM AGAINST GRAM NEGATIVE PATHOGENS: A PRELIMINARY STUDY. | 2016
Vipin Sam Alexander; Aroma Oberoi; Atul Kumar
Journal of Evolution of medical and Dental Sciences | 2015
Anuniti Mathias; Aroma Oberoi; Vipin Sam Alexander
CARBAPENEMASE PRODUCING BUGS: A THREAT TO ANTIMICROBIAL THERAPY. | 2015
Anuniti Mathias; Aroma Oberoi; Vipin Sam Alexander
Archive | 2014
Aroma Oberoi; Vipin Sam Alexander