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Featured researches published by Virginia L. Fox.


Experimental Biology and Medicine | 1961

Immunologic identification of Coxsackie A21 virus with Coe virus.

Nathalie J. Schmidt; Virginia L. Fox; Edwin H. Lennette

Summary Cross neutralization tests in HeLa cell cultures, using both the monolayer and metabolic-inhibition technics, show the Coe virus, etiologically associated with respiratory disease, to be immunologically indistinguishable from the recently-described Cox-sackie group A, type 21, virus.


Experimental Biology and Medicine | 1970

Antigenic Variation of Rhinovirus Type 22

Jack H. Schieble; H. Lennette; Virginia L. Fox

Summary Seventeen of eighteen type 22 rhinoviruses isolated in this laboratory were shown to be antigenic variants of the prototype strain (127-CV22). The variant viruses were neutralized poorly or not at all by immune serum to the prototype strain. However, immune serum prepared to one of the variant viruses (Chase) neutralized both the prototype and homologous strains to similar titer and also neutralized all of the other isolates. The neutralizing reactivity of the Chase virus immune serum for the prototype and homologous strains was found to be essentially unaltered by multiple absorptions with human liver powder, a procedure capable of removing cytoxic factors or nonspecific inhibitors found in certain rhinovirus antisera. The Chase virus thus appears to represent a “prime strain” of rhinovirus type 22. The authors acknowledge the excellent technical assistance of Mrs. Dana Gallo and Mrs. Florence Lester.


Experimental Biology and Medicine | 1968

Rhinoviruses The Isolation and Characterization of Three New Serologic Types

Jack H. Schieble; Edwin H. Lennette; Virginia L. Fox

Summary Three new rhinovirus immuno-types (FO2-2317, FO2-2513 and FO2-2547) were recovered from military recruits at Fort Ord, California. These new viruses were shown to be small RNA viruses which are inactivated at low pH and do not contain lipids as an essential structural component. Thus, they can be classified as human rhinoviruses. Reciprocal neutralization tests show them to be serologically distinct from the presently recognized 55 prototype rhinoviruses and on the basis of one-way neutralization tests they also appear to be distinct from certain other previously described candidate rhinoviruses.SummaryThree new rhinovirus immuno-types (FO2-2317, FO2-2513 and FO2-2547) were recovered from military recruits at Fort Ord, California. These new viruses were shown to be small RNA viruses which are inactivated at low pH and do not contain lipids as an essential structural component. Thus, they can be classified as human rhinoviruses. Reciprocal neutralization tests show them to be serologically distinct from the presently recognized 55 prototype rhinoviruses and on the basis of one-way neutralization tests they also appear to be distinct from certain other previously described candidate rhinoviruses.


American Journal of Epidemiology | 1967

A PROBABLE NEW HUMAN PICORNAVIRUS ASSOCIATED WITH RESPIRATORY DISEASE

Jack H. Schieble; Virginia L. Fox; Edwin H. Lennette


American Journal of Epidemiology | 1958

The Coe virus: an apparently new virus recovered from patients with mild respiratory disease.

Edwin H. Lennette; Virginia L. Fox; Nathalie J. Schmidt; James O. Culver


American Journal of Epidemiology | 1957

A colorimetric method for the typing of adenoviruses.

Edwin H. Lennette; Beverly Jean Neff; Virginia L. Fox


American Journal of Epidemiology | 1960

ADENOVIRUS VACCINE: EVALUATION OF ANTIBODY RESPONSE AND PROTECTIVE EFFICACY AND COMPARISON WITH AN EARLIER PREPARATION

Edwin H. Lennette; John D. Flintjer; James O. Culver; Virginia L. Fox; Thirza E. Stevens


American Journal of Epidemiology | 1959

ADENOVIRUS VACCINEA STUDY OF THE COMPLEMENT-FIXING AND NEUTRLIZING ANTIBODY RESPONSE

James O. Culver; Edwin H. Lennette; John D. Flintjer; Thirza E. Stevens; Virginia L. Fox


Journal of Laboratory and Clinical Medicine | 1962

Colorimetric test in HeLa cell system for assay of neutralizing antibodies to ECHO viruses.

Nathalie J. Schmidt; Tak T. Shinomoto; Juanita Dennis; Shirley J. Hagens; Virginia L. Fox; Edwin H. Lennette


Journal of Immunology | 1962

Studies on the Hemagglutination of Coe (Coxsackie A21) Virus

Nathalie J. Schmidt; Virginia L. Fox; Edwin H. Lennette

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Nathalie J. Schmidt

United States Department of State

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Jack H. Schieble

United States Department of State

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H. Lennette

United States Department of State

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Juanita Dennis

United States Department of State

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Shirley J. Hagens

United States Department of State

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Tak T. Shinomoto

United States Department of State

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