Vishnu K. Tandon
University of Lucknow
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Featured researches published by Vishnu K. Tandon.
Synthetic Communications | 2001
Vishnu K. Tandon; Rakeshwar B. Chhor
Various 1,3,4-oxadiazoles have been synthesized in excellent yields by BF3ċEt2O promoted cyclodehydration of 1,2-diacyl and diaroyl hydrazines prepared in situ from corresponding acid chlorides and hydrazine.
European Journal of Medicinal Chemistry | 2009
Vishnu K. Tandon; Hardesh K. Maurya; Ashutosh Tripathi; G.B. ShivaKeshava; Praveen K. Shukla; Pallavi Srivastava; Dulal Panda
A series of 2-chloro-3-arylsulfanyl-[1,4]naphthoquinones (2), 2,3-bis-arylsulfanyl-[1,4]naphthoquinones (3) and 12H-benzo[b]phenothiazine-6,11-diones and their analogs 6-8 were synthesized and evaluated for their antiproliferative activity against human cervical cancer (HeLa) cells. Compounds 3a and 3b were found to possess most potent antiproliferative and cell killing ability. Compounds 1-8 were also evaluated for antifungal activities. The structure-activity relationship of these compounds was studied and the results show that compound 2a (MIC(50)=1.56 microg/mL) exhibited in vitro potent antifungal activity compared to the clinically useful antifungal drug Fluconazole (MIC(50)=2.0 microg/mL) against Sporothrix. schenckii. Compound 2a (MIC(50)=1.56 microg/mL) also exhibited same antifungal activity compared to clinically useful drug Amphotericin-B (MIC(50)=1.56 microg/mL) against Trichophyton. mentagraphytes.
European Journal of Medicinal Chemistry | 2010
Vishnu K. Tandon; Hardesh K. Maurya; Manoj K. Verma; Rohitashw Kumar; Praveen K. Shukla
2-chloro-3-(4-methylpiperazin-1-yl)naphthalene-1,4-dione (3a), 2-chloro-3-(pyrrolidin-1-yl)naphthalene-1,4-dione (3b), 2-chloro-3-(piperidin-1-yl)naphthalene-1,4-dione (3c), 2-chloro-3-morpholinonaphthalene-1,4-dione (3d), 2-chloro-3-(2-phenylhydrazinyl)naphthalene-1,4-dione (3e), 2-(allylamino)-3-chloronaphthalene-1,4-dione (3f), 2-(3-chloro-1,4-dioxo-1,4-dihydronaphthalen-2-ylthio)acetic acid (3g), 2-(3-chloro-1,4-dioxo-1,4-dihydronaphthalen-2-ylthio)succinic acid (3h), methyl 2-(3-chloro-1,4-dioxo-1,4-dihydronaphthalen-2-ylthio)acetate (3i), 2-chloro-3-(2-mercaptoethylthio)naphthalene-1,4-dione (3j), 3-hydroxy-4-methyl-4H-naphtho[2,3-b][1,4]thiazine-5,10-dione (3k) and compounds 3l-q have been synthesized by a green methodology approach using water as solvent and evaluated for their antifungal and antibacterial activity. The antifungal profile of 3a-n indicated that compounds 3a-d, 3j, 3e and 3k have potent antifungal activity. Amongst the most promising antifungal compounds, 3a-g, 3j, 3k showed better antifungal activity than clinically prevalent antifungal drugs Fluconazole and Amphotericin-B against Trichophyton mentagraphytes and compounds 3j and 3k have been found to be lead antifungal bicyclic and tricyclic 1,4-naphthoquinones. Compound 3k also exhibited pronounced antibacterial activity.
Bioorganic & Medicinal Chemistry Letters | 2011
Vishnu K. Tandon; Hardesh K. Maurya; Nripendra N. Mishra; Praveen K. Shukla
Various oxygen containing 1,4-naphthoquinone derivatives have been synthesized chemoselectively by an economical, viable green methodology approach using water as solvent with or without surfactants such as Triton X-100, SDS, LD (laundry detergent), and TBAB, a phase transfer catalyst and evaluated for their in vitro antifungal and antibacterial activity. The antifungal profile of 3, 4a, 4b, and 6 indicated that compounds 3a, 3b, 4b, 6a, and 6c have potent antifungal activity compared to clinically prevalent antifungal drugs Fluconazole and Amphotericin-B against Sporothrix schenckii, Trichophyton mentagraphytes, and Candida parapsilosis and compound 3b has been found to be a lead antifungal agent for further study.
Tetrahedron | 1990
Vishnu K. Tandon; J. M. Khanna; Animesh Chandra; Nitya Anand
Abstract cis - and trans - amino alcohols 1a and 2a and their derivatives have been synthesised and their stereochemistry studied. Stereochemical studies have shown that cis -isomer is thermodynamically more favoured than the trans -isomer.
Heterocycles | 2008
Vishnu K. Tandon; Hardesh K. Maurya
Concise intramolecular cyclization reaction of 2,3-diamino-1,4-dihydro-naphthalenediones 4 and 7 in anhydrous K 2 CO 3 /Et 3 N and EtOH yielded novel 1,4-benzodiazepines 5 and 6 fused with 1,4-naphthoquinone nucleus.
Heterocycles | 2010
Vishnu K. Tandon; Anoop K. Awasthi; Kunwar A. Singh; Hardesh K. Maurya; Sanjay K. Gautam
Favorskii type rearrangement of cyclic α-bromo ketones 2 is promoted by NiCl 2 in refluxing methanol, giving the rearranged carboxylic acid ester 3 in excellent yields. The reaction of 4-bromo-2,3,4,5-tetrahydronaphth [2,1-b]oxepin-5-one (5) and its regioisomer 8 with NiCl 2 in MeOH resulted in Favorskii rearranged carboxylic acid esters 6 and 9 respectively.
Tetrahedron Letters | 2001
Vishnu K. Tandon
The reaction of (S)-(+)-3-hydroxytetrahydrofuran with phenyl methyl ketene in presence of n-BuLi and Et2Zn results in the formation of the diastereomeric esters (SS+SR) with a high degree of diastereoselectivity (98:2).
RSC Advances | 2014
Vishnu K. Tandon; Hardesh K. Maurya; Sandeep Kumar; Aijaz Rashid; Dulal Panda
This article describes the preparation of 2-heteroaryl and 2,3-diheteroaryl-1,4-naphthoquinones by an environmentally benign short synthetic route with the goal of finding 1,4-naphthoquinone derivatives that induce apoptosis in cancer cells. We have identified three most active naphthoquinones 10, 12 and 15 that potently induce apoptosis in human cervical carcinoma (HeLa) cells. One of these three compounds perturbed both microtubule and actin filaments.
Sulfur Reports | 2003
Vishnu K. Tandon; Sanjay Rai
Abstract TosMIC, a versatile synthon in organic chemistry, has been extensively used for the synthesis of a wide variety of small, medium and large ring heterocycles. It has immense implications in the synthesis of nitriles, aldehydes, ketones, alkanes, cyclophanes and large number of natural products. Several drug intermediates and pharmacologically active compounds have been synthesized from TosMIC. In addition, chiral TosMIC analogs have been synthesized and employed for synthesis of optically active compounds.