Viviane Cecília Kessler Nunes Deuschle

Análise farmacoterapêutica de pacientes atendidos pelo programa HIPERDIA

Objective: This study aimed to verify the occurrence of Problems Related to Medications (PRMs) in patients treated by the Hiperdia program. Methods: Diabetic and/or hypertensive patients were selected and the evaluation of pharmacotherapy was performed through the Dader method, followed by the identification and classification of PRMs. Results: Among the 33 patients, 9 were male and 24 were female, with a mean age of 65.82 ≤ 10.7 years. 18 patients were only hypertensive, 1 patient was diabetic only and 14 patients presented the two pathologies in association. The mean number of medications used was 5.52 ≤ 2.14, the number of PRMs found was 34, distributed among 75.75% (n = 25) of the patients, of which 58.82% and 32.35% were related to insecurity (PRM 5) and ineffectiveness (PRM 3), respectively. Conclusions: These data demonstrate that the patients enrolled in the Hyperdia group need a Pharmaceutical Care for the prevention and resolution of PRMs and consequent rational use of medicin.

Physical chemistry evaluation of stability, spreadability, in vitro antioxidant, and photo-protective capacities of topical formulations containing Calendula officinalis L. leaf extract

A calendula e amplamente utilizada em formulacoes cosmeticas, apresentando compostos fenolicos em sua constituicao quimica. Desta forma, o objetivo desta pesquisa foi desenvolver e avaliar a estabilidade de formulacoes topicas contendo 5% de extrato hidroetanolico das folhas de calendula, bem como a espalhabilidade, capacidade antioxidante e fotoprotetora in vitro nas mesmas. Para a avaliacao da estabilidade, foram usados parâmetros como a verificacao das caracteristicas organolepticas, pH e viscosidade. A capacidade antioxidante foi verificada pelo metodo do DPPH (2,2-difenil,1- picril-hidrazila) e a capacidade fotoprotetora pela medida espectrofotometrica do FPS. Para as formulacoes testadas, observou-se que apresentaram uma boa estabilidade. As formulacoes de creme e gel com extrato de calendula nao apresentaram variacoes significativas nos valores de pH e o creme apresentou as menores variacoes de viscosidade em relacao ao gel. A espalhabilidade das formulacoes de gel foi superior a do creme. As formulacoes tambem apresentaram uma boa capacidade antioxidante e um FPS em torno de 1.75. De acordo com os resultados, a formulacao pode ser utilizada com acao antioxidante, porem com o FPS obtido, a calendula nao pode ser considerada um filtro solar isolado, mas podera ser testada em estudos futuros para verificar a potencializacao de filtros solares sinteticos.

Cross-sectional study of the dispensation of synthetic anorectic drugs in community pharmacies in the city of Cruz Alta - State of Rio Grande do Sul

Obesity is defined as the excess adipose tissue in the body. Drugs responsible for inhibiting the appetite are called anorectics or appetite suppressants. Sibutramine, fenproporex and amfepramone belongs to this class, and are capable of causing physical or psychological dependence. The aim of this study was to evaluate the frequency of prescriptions for appetite suppressants in community pharmacies at Cruz Alta, State of Rio Grande do Sul, Brazil. The sales of fenproporex, amfepramone and sibutramine in the months of September, October and November 2010 and April, May and June 2011 were compared. It was observed that the most commonly dispensed anorectic in the three community pharmacies analyzed was sibutramine. In the months of September, October and November 2010, consumption was higher, with sibutramine achieving 40.3% of overall sales, amfepramone 21% and, finally, fenproporex, 7.9%. The consumption of appetite suppressants was more prevalent in females, who represented 82% of total. The results suggested the existence of high consumption of anorectics, possibly related to the current concern with aesthetic standards, which emphasizes the importance of strict control over the marketing of these substances.