Vladimir Presečki
University of Zagreb
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Featured researches published by Vladimir Presečki.
Cancer Letters | 1998
Vladimir Babuš; Marija Strnad; Vladimir Presečki; Mirjana Katičić; Smilja Kalinic; Melita Balija
The seroprevalence of Helicobacter pylori infection was studied in a population from two areas of Croatia with significantly different average gastric cancer (GC) cumulative incidence and mortality rates. In a random sample of 456 blood sera from both areas, which was tested with the ELISA Helicobacter pylori-antibody test, 48.8% of people in the north and 53.3% in the south of the country were found to be infected. The difference between the two areas in the seroprevalence of the infection was not statistically significant, nor did their populations differ in age, sex, educational background, smoking habit or wine consumption. Our results do not point to any association between the prevalence of Helicobacter pylori infection and the level of cumulative incidence and GC mortality levels.
Chemotherapy | 1998
Smilja Kalenić; Vanda Plečko; Sanja Krešić; Vladimir Presečki; Vesna Tripković; Lidija Žele-Stračević; Mirjana Katičić; Mara Dominis
Helicobacter pylori resistance to macrolides is possibly an important factor for the failure of macrolide therapy for H. pylori infection. The aim of this study was to assess the propensity of H. pylori to develop in vitro resistance to azithromycin. In 73 clinical isolates taken from patients before starting antimicrobial therapy of H. pylori infection, MIC was determined using an agar dilution method (Müller-Hinton agar with 7.5% unlysed horse blood, pH = 7.2, at 35°C, during 72 h in a humid microaerobic atmosphere). Each strain was first cultivated at half minimal inhibitory concentration (MIC) then in doubling concentrations until growth arrest. All experiments for induction of resistance were performed on the same media, incubation temperature, atmosphere and time of MIC determination. MIC interpretative standards for sensitivity, intermediate sensitivity and resistance of H. pylori to azithromycin were ≤2, 4 and ≥8 mg/l, respectively. Of 73 strains, 5 died during the experiments, and in the remaining 68 strains, serial passage with increasing azithromycin concentrations resulted in the development of resistance in 19 (26.9%) strains. Two strains had an MIC of 16 mg/l azithromycin. Thirty-three (48.5%) strains kept the same MIC or doubled their MIC, 16 (23.5%) strains had 4- to 16-fold MIC but still remained sensitive, 2 resistant strains had 128-fold MICs and 17 resistant strains had increased their MICs more than 128 times. Seventeen highly resistant strains (MIC >128 mg/l) were kept frozen at –70°C for 3 months in a brain-heart infusion broth with 15% glycerol. MIC was assessed again to determine the stability of resistance. Eleven strains kept MICs >128 mg/l, 2 became sensitive and 1 intermediate, but reverted easily, after only 2 passages, to an MIC of >128 mg/l azithromycin. Although macrolides are very active against H. pylori, the propensity to develop resistance in a high proportion of strains has a clear impact on the choice of the right combinations of macrolides with other agents as well as the dosage of the macrolide antibiotics.
Croatian Medical Journal | 2009
Tajana Filipec Kanižaj; Miroslava Katičić; Vladimir Presečki; Slavko Gašparov; Vesna Čolić Cvrlje; Branko Kolarić; Anna Mrzljak
XIIIth International Workshop on Gastroduodenal pathology and Helicobacter Pylori | 2000
Miroslava Katičić; Marija Prskalo; Mirjana Tićak; Branka Šabarić; Bruno Škurla; Tajana Filipec; Vladimir Presečki; Vesna Čolić-Cvrlje; Mara Dominis; Branko Papa; Slavica Naumovski-Mihalić; Smilja Kalenić; Vanda Plečko; Sonja Džebro
Collegium Antropologicum | 2008
Marinko Marušić; Vladimir Presečki; Miroslava Katičić; Ante Bilić; Dragan Jurčić; Dragan Schwarz
Collegium Antropologicum | 2006
Marinko Marušić; Vladimir Presečki; Miroslava Katičić; Mara Dominis; Smilja Kalenić
Lijec̆nic̆ki vjesnik | 2018
Marija Strnad; Vladimir Presečki; Vladimir Babuš; Stjepan Turek; Mara Dominis; Smilja Kalenić; Andrija Hebrang; Miroslava Katičić
Summary of XX International Workshop on Helicobacter and related bacteria in chronic digestive inflammation | 2008
Tajana Filipec Kanižaj; Miroslava Katičić; Vladimir Presečki; Mirjana Tićak; Bruno Škurla; Marija Prskalo; Branka Šabarić; Slavica Naumovski-Mihalić; Vesna Čolić Cvrlje
Acta Clinica Croatica | 2008
Karmen Brajša; Željko Ferenčić; Miroslava Katičić; Berislav Bošnjak; Vladimir Presečki; Radan Spaventi; Marija Dominis
Hepato-gastroenterology | 2006
Karmen Brajša; Željko Ferenčić; Miroslava Katičić; Senka Radošević; Vladimir Presečki; Radan Spaventi; Marija Dominis