Vladimíra Vallová
Masaryk University
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Publication
Featured researches published by Vladimíra Vallová.
European Oncology and Haematology | 2012
Lucie Mouková; Vladimíra Vallová; Iva Slámová; Miroslava Kiššová; Petr Kuglík
Tumors are frequently characterized by series of cytogenetic abnormalities. Amplifications of hTERC (3q26) and MYCC (8q24) genes have been associated with cervical intraepithelial neoplasia (CIN) and carcinoma of uterine cervix. The results of genetic analysis could select patients with high risk of progression from CIN to carcinoma. In this study, chromosomal abnormalities in cytology specimens of cervical carcinoma or CIN of 26 patients were analyzed using new developed triple-colour HPV-FISH assay. HPV infection was proven in 85 % (22/26) of patients. Amplification of hTERC and MYCC gene was found in 46 % (12/26) and 62 % (16/26) of patients, respectively. Based on these results we were able to divide patients into high-risk, medium-risk and low-risk group. We confirmed that HPV-FISH assay can be used as an effective diagnostic procedure to identify patients carrying highly risking HPV infection and chromosomal aberrations associated with this malignancy. Patients of the high-risk group would benefit from intensive dispensarisation and aggressive therapy in the future. Tumors are frequently characterized by series of cytogenetic abnormalities. Amplifications of hTERC (3q26) and MYCC (8q24) genes have been associated with cervical intraepithelial neoplasia (CIN) and carcinoma of uterine cervix. The results of genetic analysis could select patients with high risk of progression from CIN to carcinoma. In this study, chromosomal abnormalities in cytology specimens of cervical carcinoma or CIN of 26 patients were analyzed using new developed triple-colour HPV-FISH assay. HPV infection was proven in 85 % (22/26) of patients. Amplification of hTERC and MYCC gene was found in 46 % (12/26) and 62 % (16/26) of patients, respectively. Based on these results we were able to divide patients into high-risk, medium-risk and low-risk group. We confirmed that HPV-FISH assay can be used as an effective diagnostic procedure to identify patients carrying highly risking HPV infection and chromosomal aberrations associated with this malignancy. Patients of the high-risk group would benefit from intensive dispensarisation and aggressive therapy in the future.
Molecular Cytogenetics | 2015
Eva Hladílková; Tuva Barøy; Madeleine Fannemel; Vladimíra Vallová; Doriana Misceo; Vesna Bryn; Iva Slámová; Šárka Prášilová; Petr Kuglík; Eirik Frengen
International Journal of Clinical and Experimental Pathology | 2014
Petr Kuglík; Jan Smetana; Vladimíra Vallová; Lucie Mouková; Kateřina Kašíková; Michaela Cvanová; Lucie Brožová
Archive | 2007
Pavel Němec; Henrieta Grešliková; Romana Zaoralová; Hana Filková; Vladimíra Vallová; Renata Kupská; Jana Smejkalová; Alexandra Oltová; Petr Kuglík; Roman Hájek
Neoplasma | 2016
Markéta Wayhelová; Aneta Mikulášová; Jan Smetana; Vladimíra Vallová; Dita Matuchová; Hana Filková; Lucie Mouková; Petr Kuglík
Časopis lékařů českých | 2015
Petr Kuglík; Jan Smetana; Darja Němcová; Vladimíra Vallová; Aneta Mikulášová; Renata Gaillyová; Vít Hubinka; Marek Koudelka
Praktická gynekologie | 2013
Petr Kuglík; Anna Laštůvková; Vladimíra Vallová; Kateřina Kašíková; Lucie Mouková
Archive | 2013
Aneta Mikulášová; Vladimíra Vallová; Jan Smetana; Henrieta Grešliková; Renata Kupská; Lucie Říhová; Anna Potáčová; Viera Sandecká; Luděk Pour; Petr Kuglík; Roman Hájek
Klinická onkologie | 2013
Kristina Štěpanovská; Gabriela Vaňková; Veronika Némethová; Lenka Tomášiková; Petra Šmuhařová; Eva Divíšková; Vladimíra Vallová; Petr Kuglík; Karla Plevová; Alexandra Oltová; Michael Doubek; Šárka Pospíšilová; Jiří Mayer
Blood | 2013
Vladimíra Vallová; Jan Smetana; Henrieta Grešliková; Renata Kupská; Michaela Purgertova; Lucie Rihova; Viera Sandecká; Ludek Pour; Miroslav Penka; Petr Kuglík; Roman Hájek
