Vunnam Venkateswarlu

CH Oxygenation and N‐Trifluoroacylation of Arylamines Under Metal‐Free Conditions: A Convenient Approach to 2‐Aminophenols and N‐Trifluoroacyl‐ortho‐aminophenols

Direct ortho-hydroxylation through C-H oxygenation and N-trifluoroacylation of anilines was achieved in a single step under metal-free conditions by using a combination of TFA and oxone. The method allowed the formation of functionalised amino phenolic compounds such as ortho-hydroxy-N-trifluoroacetanilides in good yields with broad substrate scope.

Role of Cryosurgery in the Surgical Management of Nasoalveolar Cyst

Nasoalveolar cysts are rare developmental, non-odontogenic soft tissue lesions present in the submucosal area of the nasal alar region of the face. The management of nasoalveolar cyst is surgical excision or enucleation by sublabial approach. Most of the times surgeon finds difficult in complete removal of cyst wall especially in the infected cases. We have introduced a technique of cryo probe destruction of the epithelial remnants of the cystic wall after routine surgical excision. The results are encouraging.

Direct N-heterocyclization of hydrazines to access styrylated pyrazoles: synthesis of 1,3,5-trisubstituted pyrazoles and dihydropyrazoles

A microwave-assisted method has been developed for the synthesis of tri-substituted pyrazoles via direct N-heterocyclization of hydrazines with metal-acetylacetonate and -dibenzylideneacetonate without using any base or additives. Most importantly, the synthesis of 1-aryl-5-phenyl-3-styryl-1H-pyrazoles was achieved in a single step using hydrochloride salt of various phenylhydrazines and this is the first report for direct construction of these molecules. The reaction medium and microwave conditions play a critical role for their selective product formation during the reaction. The present reaction explored the usage of metal-diketonic complexes as reaction substrates providing acetylacetone and dibenzylideneacetone moieties to directly participate in cyclization with hydrazines to form the corresponding pyrazoles in excellent yields. The present protocol introduces the important N-heterocyclic moieties in the final structures, giving the reaction great applications from a medicinal chemistry perspective, particularly in the late stage modification strategies in drug discovery.