W.A. Taylor

Anti-Allergic Actions of Disodium Cromoglycate and Other Drugs Known to Inhibit Cyclic 3′,5′-Nucleotide Phosphodiesterase

Disodium cromoglycate (DSCG) inhibited rat peritoneal mast cell degranulation induced by anti-rat serum, noradrenaline, imidazole, phospholipase-A, and antigen. Antigen-induced degranulation was also

The Anti-Anaphylactic Actions of Disodium Cromoglycate, Theophylline, Isoprenaline and Prostaglandins

Various drugs used in the treatment of either allergy or inflammation have been studied in the rat. Prausnitz-Kustner (PK) type reactions, passive cutaneous anaphylaxis (PCA) and peritoneal mast cell

Effect of Disodium Cromoglycate on Various Types of Anaphylactic Reaction in the Guinea Pig

The development of allergic reactivity and the effect of disodium cromoglycate (DSCG) on that development were studied in groups of actively sensitized guinea pigs using both ocular sensitivity and an

Selective Inhibition by Betamethasone of Allergen-Induced Release of SRS-A from Human Lung

Passively sensitized human lung, when incubated with the appropriate allergen, released histamine and slow-reacting substance (SRS-A). Betamethasone sodium phosphate (5-100 microgram/ml), preincubated with the lung overnight, suppressed, in a dose-related manner, the release of SRS-A without having an effect on the release of histamine. Preincubation for only 1 h produced little effect on the release of SRS-A or of histamine. These results may help to explain some of the beneficial effects of glucocorticoids in allergic asthma.

Mast Cell Degranulation: A Comparison of the Inhibitory Actions of Disodium Cromoglycate, Drugs Known to Influence the Level of Intracellular Cyclic Nucleotide and Diisopropylfluorophosphate (DFP)

Rat peritoneal mast cells have been used to study further the effect of drugs on the calcium-independent and calcium-dependent stages of phospholipase-A-induced mast cell degranulation. Evidence is pr

Effect of Lung Tissue on the Inhibitory Actions of Isoprenaline, Theophylline, Disodium Cromoglycate and PGE1 on Antigen-Induced Mast Cell Degranulation

Isoprenaline, disodium cromoglycate and PGE1 poorly inhibit antigen-induced degranulation of sensitised rat peritoneal mast cells, but in the presence of chopped rat lung their inhibitory activities were markedly enhanced. The chopped lung preparation had no effect on degranulation in the absence of an inhibitor and did not enhance the weak inhibitory potency of theophylline. Lung tissue suspensions pretreated with isoprenaline released a factor into the supernatant which enhanced the action of isoprenaline on peritoneal mast cells. The activity of this supernatant factor was destroyed by boiling for 5 min. Supernatant fluid from untreated lung tissue did not itself reduced antigen-induced degranulation or enhance the inhibitory potency of isoprenaline.

Standardization of Radioallergosorbent Test (RAST) and Allergen Extracts in Terms of the WHO Standard for IgE

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