W D Foley

The sacroiliac joints: anatomic, plain roentgenographic, and computed tomographic analysis.

Due to its unique bicompartmental anatomy and spatial configuration, the sacroiliac joint can be more accurately defined by computed tomography (CT) than conventional radiography. Using a tilted gantry and paraaxial scanning technique, the synovial portion of the joint is oriented vertically on the CT image, while the ligamentous portion is oriented oblique-horizontally. The tilted CT gantry technique allows full ventral-dorsal imaging of the synovial portion of the sacroiliac joint. We have found the accuracy of CT to be superior to conventional radiography in the detection of early erosive sacroiliitis and joint space narrowing. In all patients with discrepancy between the two radiologic techniques, the changes were either only demonstrated or better demonstrated by CT than conventional radiography.

Evaluation of renal transplants with pulsed Doppler duplex sonography.

Sixty‐seven patients who had had renal transplants were examined 184 times by pulsed Doppler duplex sonography, and a pulsed Doppler index (PDI) was developed to provide an indicator of renal blood‐flow patterns. Arterial Doppler signals were obtained from transplant vessels during all technically satisfactory examinations of viable allografts; interpretations of transplant status based on the PDI and clinical function studies agreed with radionuclide renogram diagnoses in more than 90 per cent of cases when both sonograms and renograms were available. Pulsed Doppler analysis may differentiate between arterial occlusion and severe rejection and may decrease the need for radionuclide studies in some patients.

Survival of patients with resectable pancreatic cancer who received neoadjuvant therapy

BACKGROUND Enthusiasm for neoadjuvant therapy is growing from the emerging consensus that pancreatic cancer is a systemic disease at the time of diagnosis. Those who remain in favor of upfront surgery often cite the lack of reported data to support alternative treatment sequencing. We therefore report the results of all patients treated outside of a clinical trial under the direction of a multidisciplinary pancreatic cancer working group. METHODS We reviewed all patients with resectable pancreatic cancer treated with neoadjuvant therapy (NeoTx) from 2009 to 2013; we excluded those patients treated on prospective clinical trials as they will be the subject of subsequent reports. Data regarding demographics, NeoTx, operative outcomes, pathology, and survival data were abstracted from a prospective database. RESULTS NeoTx was initiated in 69 patients; median age was 65 years (interquartile range [IQR]: 11) and median carbohydrate antigen 19-9 at diagnosis was 96.5 (IQR 210). NeoTx consisted of chemotherapy alone (n = 10, 14%), chemotherapy and radiation (chemoradiation, n = 53, 77%), or both (n = 6, 9%). Median carbohydrate antigen 19-9 after NeoTx was 39 (IQR 104) corresponding to a median decrease of 60%. Operative resection was completed in 60 (87%) of the 69 patients. At restaging after NeoTx, 5 (7%) of 69 patients were not considered candidates for surgery because of the development of metastatic disease (n = 4) or an inadequate performance status (n = 1). At the time of surgery, 4 (6%) of 64 patients had metastatic disease found at laparoscopy. Of the 60 patients who underwent surgical resection, a complete pathologic response was observed in 2 (3%) patients; 20 (33%) had positive lymph nodes, and the median number of positive lymph nodes was 2 (IQR 3). R0 resections were achieved in 58 (97%) of the 60 patients. Additional postoperative adjuvant therapy was administered to 37 (62%) of the 60 patients. Median survival of all 69 patients was 31.5 months; 44.9 months for the 60 patients who completed all NeoTx and resection compared with 8.1 months for the 9 patients who were not resected (log rank P < .001). CONCLUSION NeoTx for resectable pancreatic cancer was associated with a median overall survival of 32 months; something not reported for patients treated with surgery first if based on intent-to-treat analysis. Treatment sequencing may provide an oncologic benefit beyond that of the selection bias afforded surgery after a period of induction therapy.

Color Doppler sonography in the evaluation of the adult acute scrotum.

Color Doppler sonography (CDS) was used to evaluate 35 adult males with acute scrotal discomfort. Correlative nuclear scintigraphy was performed in 15 patients. Surgical correlation was available in 10 patients with clinical follow‐up in the remaining 25. The complete absence of intratesticular color flow was used as our criterion for testicular ischemia. This was found to be 100% sensitive and 100% specific in 8 patients with surgically confirmed testicular ischemia. Spontaneous detorsion was noted in one patient with hyperemia demonstrated by color imaging. Increased color flow was found in 20 patients with the clinical impression of scrotal inflammation. Nuclear scintigraphy and color Doppler imaging had 100% agreement in 15 patients. Color Doppler sonography is a useful and highly accurate diagnostic method in the evaluation of patients with the acute scrotal syndrome. Color flow imaging is comparable to nuclear scintigraphy in the diagnosis of testicular ischemia.

Hepatic Metastases: CT Versus MR Imaging at 1.5T

A prospective multi-institutional study was performed to compare the sensitivity of computed tomography (CT) and high-field magnetic resonance (MR) imaging (1.5T) in the detection of hepatic metastases, T1-weighted and T2-weighted spin-echo (SE) MR images were compared with noncontrast, dynamic, and delayed CT. Sixty-nine oncology patients were studied. Non-contrast CT showed an overall sensitivity of 57%, dynamic CT 71%, delayed CT 72%, T1-weighted SE MR 47%, and T2-weighted SE MR 78%. Although there was no statistically significant (p}<0.05) difference among dynamic CT, delayed CT, and T2-weighted SE MR, these three methods were significantly more sensitive (p< 0.005) than non-contrast CT or T1-weighted SE MR. T2-weighted SE MR was significantly more sensitive (p< 0.006) than CT or T1-weighted SE MR in the detection of small (<1 cm) lesions. CT was more sensitive in the detection of extrahepatic disease. These data confirm the superiority of T2-weighted SE over T1-weighted SE pulse sequences at 1.5T.

Ablation of liver metastasis: is preoperative imaging sufficiently accurate?

The recent introduction of cryotherapy and radiofrequency ablation of liver metastasis has expanded the indications for treatment. As technology has advanced, a percutaneous approach has been developed. Percutaneous treatment, however, requires accurate preoperative imaging. From 1993 to 1999, 179 patients underwent operative exploration for treatment of suspected hepatic metastases from colorectal carcinoma. One hundred seventy-seven patients were staged by preoperative CT, two patients were staged by MRI, and complete data were available in 176. Hepatic tumor count by preoperative imaging was compared to intraoperative tumor count obtained by inspection, palpation, ultrasonographic examination using a 3S/7.5 MHz T probe, and careful gross sectioning of the resected specimen. Post hoc analysis was performed on 35 CT scans by two radiologists who specialize in abdominal CT These radiologists were blinded to the intraoperative findings. Their interpretations were compared to the intraoperative counts and to each other. Thirty-four (19%) of 179 patients were deemed untreatable at operation because of unsuspected overwhelming liver involvement in 11 (6%) or extrahepatic metastases in 23 (13%). For the group, CT was accurate in 80 patients (45%), showed more lesions than were found in 16 (9%), and showed fewer metastases than were found in 80 (45%). When the preoperative scan predicted a solitary metastasis, it was correct in 45 (65%) of 69 patients and underestimated disease in 24 (35%). In the post hoc analysis, the mean numbers of lesions reported by the two radiologists did not differ from the mean number of tumors found; however, the radiologists’ counts agreed on 16 (59%) and disagreed on 11 (41 %) of the scans. The accuracy of CT decreased with increasing numbers of lesions. Regardless of the type of preoperative imaging, intraoperative findings altered the course of the operation in 96 (55%) of 176 patients. Preoperative imaging is not sufficiently accurate to permit adequate percutaneous treatment of hepatic metastases from colorectal carcinoma.

CT evaluation of esophageal and upper abdominal varices.

Recognition of major abdominal visceral vessels is an integral part of the interpretation of upper abdominal computed tomography (CT) studies. Perivisceral portal systemic varices appear as lobulated or discrete rounded tubular densities in characteristic sites, including periesophageal, perigastric, and peripancreatic locations, the pararenal spaces, and the gallbladder fossa. To avoid confusion with lymphadenopathy and soft tissue tumors, the varices can be specifically identified using contrast enhancement techniques and fast scan times. In portal hypertension, contrast enhanced CT can be used to define both the extrahepatic portal system and the location of the perivisceral varices.

Color Doppler Ultrasonography in the Evaluation of the Acute Scrotum

Color Doppler ultrasonography was used to assess 20 patients with the acute onset of scrotal pain. Patients were categorized into 3 groups according to the initial clinical impression of the examining physician: ischemia, inflammation or trauma. Color Doppler ultrasonography correctly predicted the need for surgery in 8 of 9 operated patients (89%) and correctly predicted the outcome in all 11 nonoperated patients (100%). The anatomical resolution possible, as well as information regarding blood flow made color Doppler ultrasonography a useful tool in the assessment of acute scrotal processes.

Histological-venographic correlates in portal hypertension.

Magnification hepatic wedge venography and manometry were evaluated in 40 patients with portal hypertension and in 6 normal individuals. Venography (alone or in combination with manometry) generally facilitated prediction of histology in cirrhosis, hepato-venular occlusive disease, periportal fibrosis, congenital hepatic fibrosis, and portal vein obstruction. The magnification wedge venograms demonstrated a number of histological features of cirrhosis that have not previously been described in vivo, including porto-hepatic vein shunts, micro- and macronodular regeneration, and obstructive changes which were more severe in hepatic than in portal veins.

CT detection of aortocaval fistula

We describe a patient in whom a secondary aortocaval fistula was diagnosed on dynamic CT by noting transient enhancement of the inferior vena cava simultaneously with maximum enhancement of the aorta. This pattern of caval enhancement is contrasted with the gradual increase and subsequent plateauing of caval opacification seen normally.