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Featured researches published by W. L. Hanson.


Pediatric Research | 1993

Pulmonary capillary recruitment in neonatal lambs

Lynda J. Means; W. L. Hanson; Kyle O. Mounts; Wiltz W. Wagner

ABSTRACT: In species having lungs large enough to develop hydrostatic perfusion zones, increased pulmonary arterial pressure causes blood flow to be redistributed from the lower to the upper lung. The blood flow increase in the upper lung recruits capillaries and increases gas exchange surface area. There is disagreement, however, about whether such capillary recruitment occurs in young animals with small lungs. To investigate this issue, we used in vivo microscopy to directly study capillary perfusion in individual alveolar walls in the upper lungs of neonatal lambs and in older lambs with larger lungs. Pulmonary arterial pressure was elevated by airway hypoxia. In neonatal lambs (<10 d old; n = 7), hypoxia increased pulmonary arterial pressure by 55% but did not cause capillary recruitment. In older lambs (20–61 d old; n = 6), hypoxia increased pulmonary arterial pressure by 40% and caused a 46% increase in recruited capillaries. These results support the hypothesis that capillary recruitment does not occur in newborn lambs when pulmonary arterial pressure increases and implies that there is limited gas exchange reserve. In older lambs, however, gas exchange reserve develops through recruitable capillaries as the lungs mature.


Journal of Applied Physiology | 1987

Physiological neutrophil sequestration in the lung: visual evidence for localization in capillaries

D. C. Lien; Wiltz W. Wagner; R. L. Capen; C. Haslett; W. L. Hanson; S. E. Hofmeister; Peter M. Henson; G. S. Worthen


Journal of Applied Physiology | 1991

Flow through zone 1 lungs utilizes alveolar corner vessels.

Wayne J. E. Lamm; K. R. Kirk; W. L. Hanson; Wiltz W. Wagner; R. K. Albert


Journal of Applied Physiology | 1989

Site of recruitment in the pulmonary microcirculation

W. L. Hanson; J. D. Emhardt; J. P. Bartek; L. P. Latham; L. L. Checkley; R. L. Capen; Wiltz W. Wagner


The American review of respiratory disease | 1990

Neutrophil Kinetics in the Pulmonary Microcirculation: Effects of Pressure and Flow in the Dependent Lung

Dale C. Lien; G. Scott Worthen; R. L. Capen; W. L. Hanson; Lori L. Checkley; Steven J. Janke; Peter M. Henson; Wiltz W. Wagner


Journal of Applied Physiology | 1990

Pulmonary microcirculatory kinetics of neutrophils deficient in leukocyte adhesion-promoting glycoproteins

M. C. Yoder; L. L. Checkley; U. Giger; W. L. Hanson; K. R. Kirk; R. L. Capen; Wiltz W. Wagner


Journal of Applied Physiology | 1986

Vertical gradient of pulmonary capillary transit times

Wiltz W. Wagner; L. P. Latham; W. L. Hanson; S. E. Hofmeister; R. L. Capen


Journal of Applied Physiology | 1990

Distribution of pulmonary capillary transit times in recruited networks

R. L. Capen; W. L. Hanson; L. P. Latham; C. A. Dawson; Wiltz W. Wagner


Journal of Applied Physiology | 1987

Pulmonary arterial transit times

C. A. Dawson; R. L. Capen; L. P. Latham; W. L. Hanson; S. E. Hofmeister; T. A. Bronikowski; D. A. Rickaby; Wiltz W. Wagner


Journal of Applied Physiology | 2000

Pulmonary vascular response of the coati to chronic hypoxia

W. L. Hanson; Dona F. Boggs; J. Michael Kay; Stephen E. Hofmeister; Osamu Okada; Wiltz W. Wagner

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Peter M. Henson

Indiana University Bloomington

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G. Scott Worthen

Children's Hospital of Philadelphia

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