W.N.N. Wan Yahya

A case of Hashimoto encephalopathy in a Malay woman with Graves disease.

Hashimoto encephalopathy (HE) is a poorly recognised steroid-responsive encephalopathy, with prominent neuropsychiatric features. Diagnosis is often difficult due to its heterogeneous clinical presentation, especially since the thyroid status or anti-thyroid antibody titres may not be related to the disease state. Here, the case of a 23-year-old Malay woman with Graves disease who presented with progressive encephalopathy diagnosed as HE is presented. She responded dramatically to high dose intravenous and then oral corticosteroid. A month after the initiation of treatment, she regained full independency.

An unusual neurological complication from a garden-variety organism: post-melioidosis parkinsonism.

A 62-year-old man presented to our tertiary hospital’s emergency department with a 4-week history of fever associated with lethargy and constitutional symptoms. For 9 days before admission, he had been vomiting two to three times per day. He had longstanding diabetes and hypertension and worked for the local city council as a truck driver, transporting water to local gardens and public areas. About 2 months previously, he had sustained an abrasion on his left foot that had healed completely at time of presentation.

LP22: The use of blink reflex study in determining the clinical recovery and quality of life in Bell’s palsy patient

oped severe generalized weakness and required mechanical ventilation. At that time, RNST was abnormal in ADQ. Treatment of WM with Rituximab dramatically improved symptoms and led to a progressive and sustained decrease of IgM and anti-MuSK titres. Six years later, patient remains stable without treatment. Discussion: Neurophysiological features studies allowed to rule out a peripheral neuropathy, played a role the diagnosis of MG and, more on, its features correlated with clinical status. Response to rituximab could throw additional light on the role of B cells as therapeutic targets in anti-MuSK positive MG.

1.094 THE PREVALENCE OF NON MOTOR SYMPTOMS AND RESTLESS LEGS SYNDROME IN PARKINSON'S DISEASE: CORRELATION WITH QUALITY OF LIFE

Results: A total of 113 patients consisting of 60 males and 53 females were recruited.The mean age was 64.8 ± 9.0 years. The median duration of illness was 5.0 (2.0-8.0) years.97.3% of patients reported the presence of NMS. The most common symptoms were gastrointestinal symptoms (76.1%), followed by neuropsychiatric symptoms (72.6%), autonomic dysfunction (64.6%) and sleep disorders (58.4%).Eleven patienst (9.7%) had RLS.Patients with PD/RLS had younger age of PD onset (p=0.023) and lower serum ferritin levels (p=0.616).NMS affected the QoL significantly in all dimensions of PDQ-39.Each dimension of PDQ-39 (mobility, activities of daily living, emotional well being, stigma, cognitions, communication and bodily discomfort) correlated strongly with the severity of NMS.