W. Peter Geis

Systemic lymphoblastic response to antithymocyte globulin in renal allograft recipients: An initial report

Abstract Three renal transplant recipients developed marked, multiple lymph node enlargement during or soon after intensive horse antihuman thymocyte globulin (ATG) therapy. This lymphoproliferative disorder is morphologically indistinguishable from malignant lymphoma of histiocytic type but is clinically different since rapid regression occurred without antitumor therapy. The disease exhibited a benign clinical course.

B-cell directed antibodies and delayed hyperacute rejection: a case report.

Transplantation in the presence of a conventional positive lymphocytotoxic crossmatch has been contraindicated for a number of years [3, lo]. With modification of this assay so that cytotoxicity to the T or B cell can be determined, a number of groups have been undertaking renal transplantation in the presence of presensitization to the B cell, with conflicting results [4, 8, 91. Delayed hyperacute rejection in the presence of such a B-cell directed alloantibody forms the basis of this article.

Acute and chronic renal failure.

Two basic mechanisms are responsible for the increasing frequency with which surgeons must deal with patients with renal failure. The author addresses these two issues in his discussion of the prophylaxis and management of postoperative acute renal failure and the surgical complications occurring in patients with chronic renal failure.