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Wallace T. Ashton

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Publication

Featured researches published by Wallace T. Ashton.

Journal of Medicinal Chemistry | 1973

Synthesis of 5-substituted quinazolines as potential antimalarial agents

Wallace T. Ashton; John Hynes

Journal of Medicinal Chemistry | 1973

Quinazolines as inhibitors of dihydrofolate reductase. 2.

John Hynes; Wallace T. Ashton; Dale Bryansmith; James H. Freisheim

Journal of Medicinal Chemistry | 1973

Irreversible enzyme inhibitors. 197. Water-soluble reversible inhibitors of dihydrofolate reductase with potent antitumor activity derived from 4, 6-diamino-1,2-dihydro-2,2-dimethyl-1-phenyl-s-triazine.

Bernard Randall Baker; Wallace T. Ashton

Journal of Medicinal Chemistry | 1975

Synthesis and evaluation of 6-arylactamido-2,4-diaminoquinazolines and related compounds as folic acid antagonists.

John Hynes; Wallace T. Ashton

Journal of Medicinal Chemistry | 1970

Irreversible enzyme inhibitors. CLXXIII. Cure of Walker 256 ascites by reversible and irreversible inhibitors of dihydrofolic reductase derived from 1-(substituted-phenyl)-4,6-diamino-1,2-dihydro-2,2-dimethyl-s-triazine

Bernard Randall Baker; Nicolaas M. J. Vermeulen; Wallace T. Ashton; Adrian J. Ryan

Journal of Medicinal Chemistry | 1973

Irreversible enzyme inhibitors. 198. Diaminodihydro-S-triazines and diaminopyrimidines bearing substituted (ureidomethyl)phenyl substituents as reversible inhibitors of dihydrofolate reductase.

Wallace T. Ashton; Larry L. Kirk; Bernard Randall Baker

Journal of Medicinal Chemistry | 1972

Synthesis of some bis(2,4-diaminopyrimidines) and bis(2,4-diaminoquinazolines) as potential antimalarial agents

John Hynes; Roy F. Gratz; Wallace T. Ashton

Journal of Medicinal Chemistry | 1970

Ireversible enzyme inhibitors. CLXXIX. Active-site-directed irreversible enzyme inhibitors of dihydrofolate reductase from 1-(3-chlorophenyl)-4,6-diamino-1,2-dihydro-2,2-dimethyl-s-triazine with oxyamide bridges to a terminal sulfonyl fluoride

Bernard Randall Baker; Wallace T. Ashton

Journal of Medicinal Chemistry | 1972

Irreversible enzyme inhibitors. 196. Active-site-directed irreversible inhibitors of dihydrofolate reductase derived from 1-(4-benzyloxy-3-chlorophenyl)-4,6-diamino-1,2-dihydro-2,2-dimethyl-s-triazine and bearing a terminal phenyl sulfonate group.

Bernard Randall Baker; Wallace T. Ashton

Journal of Medicinal Chemistry | 1970

Irreversible enzyme inhibitors. CLXXVI. Active-site-directed irreversible inhibitors of dihydrofolate reductase derived from 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-phenyl-s-triazine by ether bridging to a terminal sulfonyl fluoride

Bernard Randall Baker; Wallace T. Ashton

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Bernard Randall Baker

University at Buffalo

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John Hynes

University of South Carolina

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James H. Freisheim

University of Toledo Medical Center

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Adrian J. Ryan

University of Sydney

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