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Publication
Featured researches published by Walter Wrobel.
international conference of the ieee engineering in medicine and biology society | 2010
H. Benav; Karl U. Bartz-Schmidt; Dorothea Besch; A. Bruckmann; Florian Gekeler; Udo Greppmaier; Alex Harscher; Steffen Kibbel; Akos Kusnyerik; Tobias Peters; Helmut G. Sachs; Alfred Stett; Katarina Stingl; Barbara Wilhelm; Robert Wilke; Walter Wrobel; Eberhart Zrenner
Our group has developed a subretinal microphotodiode array for restoration of vision. In a clinical pilot study the array has been implanted in 11 patients suffering from photoreceptor degenerations. Here we present promising results from some of those patients where the retinal tissue above the chip was functional and the implant fulfilled its expected function. A spatial resolution of approximately 0.3 cycles/degree could be achieved with fine stripe patterns. In one subject where the implant had been placed directly under the macular region of the retina a visual acuity of 20/1000 could be measured. Artificially restored visual acuity of this quality has not been reported previously. Finally, we present images illustrating an approximation of how the visual perceptions might have appeared to the subjects, based on a mathematical model and patient reports.
Biomedical Microdevices | 2017
Renate Daschner; Udo Greppmaier; Martin Kokelmann; Sandra Rudorf; Ralf Rudorf; Sebastian Schleehauf; Walter Wrobel
Despite recent developments and new treatments in ophthalmology there is nothing available to cure retinal degenerations like Retinitis Pigmentosa (RP) yet. One of the most advanced approaches to treat people that have gone blind due to RP is to replace the function of the degenerated photoreceptors by a microelectronic neuroprosthetic device. Basically, this subretinal active implant transforms the incoming light into electric pulses to stimulate the remaining cells of the retina. The functional time of such devices is a crucial aspect. In this paper the laboratory and clinical reliability of the two active subretinal implants Alpha IMS and Alpha AMS is presented. Based on clinical data the median operating life of the Alpha AMS is estimated to be 3.3 years with a one-sided lower 75 % confidence level of 2.0 years. This data shows a significant improvement of the device lifetime compared to the previous device Alpha IMS which shows a median lifetime of 0.6 years with a lower confidence bound (75 %) of 0.5 years. The results are in good agreement with laboratory data from accelerated aging tests of the implant components, showing an estimated median lifetime for Alpha IMS components of 0.7 years compared to the improved lifetime of Alpha AMS of 4.7 years.
Archive | 2010
Walter Wrobel; Eberhart Zrenner; Albrecht Rothermel
Investigative Ophthalmology & Visual Science | 2009
Helmut G. Sachs; U. Bartz-Schmidt; Florian Gekeler; Dorothea Besch; Ursula Brunner; Barbara Wilhelm; Walter Wrobel; Robert Wilke; V.–P. Gabel; Eberhart Zrenner
Investigative Ophthalmology & Visual Science | 2008
Helmut G. Sachs; Ursula Brunner; Florian Gekeler; Karl U. Bartz-Schmidt; V.–P. Gabel; Walter Wrobel; A. Hekmat; Eberhart Zrenner
Investigative Ophthalmology & Visual Science | 2007
Helmut G. Sachs; Karl U. Bartz-Schmidt; Florian Gekeler; Dorothea Besch; Ursula Brunner; Barbara Wilhelm; Robert Wilke; Walter Wrobel; Veit-Peter Gabel; Eberhart Zrenner
Investigative Ophthalmology & Visual Science | 2012
Helmut G. Sachs; Karl U. Bartz-Schmidt; Florian Gekeler; Dorothea Besch; Ursula Brunner; Barbara Wilhelm; Walter Wrobel; Veit-Peter Gabel; Eberhart Zrenner
Archive | 2011
Florian Gekeler; Walter Wrobel; Andre Messias
Investigative Ophthalmology & Visual Science | 2011
Helmut G. Sachs; Karl Ulrich Bartz-Schmidt; Florian Gekeler; Dorothea Besch; Ursula Brunner; Barbara Wilhelm; Walter Wrobel; Veit-Peter Gabel; Eberhart Zrenner
Archive | 2010
Eberhart Zrenner; Karl U. Bartz-Schmidt; H. Benav; Dorothea Besch; Soeren Danz; Veit-Peter Gabel; Florian Gekeler; Heinz-Gerd Graf; Alex Harscher; Gernot Hoertdoerfer; Steffen Kibbel; Uwe Klose; Andreas F. Kopp; Akos Kusnyerik; Wilfried Nisch; Tobias Peters; Daniel Llewellyn Rathbun; Siegmar Reinert; Helmut G. Sachs; Ieva Sliesoraityte; Alfred Stett; Peter Szurman; Barbara Wilhelm; Robert Wilke; Walter Wrobel