Waltraud Steinschifter
University of Graz
Network
Latest external collaboration on country level. Dive into details by clicking on the dots.
Publication
Featured researches published by Waltraud Steinschifter.
Cancer | 1996
E. Schauenstein; M. Lahousen; Michaela Weblacher; Waltraud Steinschifter; Willibald Estelberger; Konrad Schauenstein
Malignant diseases of various tissue origin have previously been found to be associated with a characteristic shift in the serum pattern of IgG subclasses, i.e., a highly significant reduction of the percent of IgG1 and an increase of the percentage of IgG2 relative to the total IgG. In the present study we examined the diagnostic performance of this indirect tumor marker in patients with carcinomas of various sites within the female reproductive tract.
Iubmb Life | 1996
E. Schauenstein; Konrad Schauenstein; Franz Dachs; Monika Reiter; Astrid Leitsberger; Michaela Weblacher; Karin Maninger; Helene Horejsi; Waltraud Steinschifter; Carola Hirschmann; Peter Felsner
A reactive disulfide bond (SS)* was detected and characterized in IgG of humans, rats and mice by virtue of disulfide interchange with dithionitrobenzoate. (SS)* was found exclusively in human IgG1 and rat IgG2b. In human IgG1 (SS)* was identified as the upper one of the two interheavy bridges in the hinge, where it appears to take part in complement activation. The biological significance of (SS)* in IgG was underlined by the fact that no other serum proteins were found to exhibit a similar reactivity.
Cancer | 2000
Peter Felsner; Waltraud Steinschifter; Michaela Fischer; Robert Eferl; Lukas Kenner; Kurt Zatloukal; M. Lahousen; Peter M. Liebmann; E. Schauenstein; Konrad Schauenstein
Previously, it could be demonstrated that human patients with malignant diseases of various tissues exhibited characteristic and highly significant changes in the serum patterns of immunoglobulin (Ig)G subclasses, consisting of a decrease in IgG1 and an increase in IgG2 relative to total IgG. The aim of the current study was to determine whether this phenomenon was detectable at the level of IgG‐producing B lymphocytes.
Cancer | 1997
E. Schauenstein; Hans Rabl; Waltraud Steinschifter; Carola Hirschmann; Willibald Estelberger; Konrad Schauenstein
Malignant diseases of various origins were previously shown to be associated with a characteristic and highly significant change in the serum pattern of immunoglobulin (Ig)G subclasses, comprised of a decrease in %IgG1 and an increase in %IgG2 relative to and independent of the absolute concentration of total IgG. The goal of the current study was to evaluate this phenomenon as an indirect marker in the primary diagnosis of colorectal carcinoma.
Breast Cancer Research and Treatment | 2000
L. Kronberger; Waltraud Steinschifter; M. Weblacher; W. Estelberger; P.M. Liebmann; H. Rabl; M. Smola; S.F. Lax; H.J. Mischinger; E. Schauenstein; Konrad Schauenstein
The diagnostic value of the decrease in percentage of immunoglobulin G1 (%IgG1) in breast cancer was analyzed with special emphasis on early tumor stages. IgG1 and total IgG were preoperatively measured in the sera of a total of 801 individuals using a modified quantitative affinity chromatography. Group A consisted of 174 healthy individuals of both sexes, group B of 324 female patients with benign breast disease, and group C of 303 patients with invasive and non-invasive breast cancer. Within group C, 13 patients presented with intraductal carcinoma, and 22 patients with a pT1a-tumour (diameter less than 0.5 cm). The %IgG1 values were compared among groups A, B and C. In addition, correlations were sought between %IgG1 values of group C and tumor size, stage (UICC), histopathological grade and oestrogen (ER) and progesteron receptor (PR) expression. The mean value of %IgG1 in group A was 63.3 ± 0.5 s.e.m., in group B 57.75 ± 0.4 s.e.m. and in group C 52.37 ± 0.5 s.e.m. The differences of mean values were highly significant between all three groups. Sensitivity and specificity of %IgG1 to discriminate between group A and C were 75% and 87%, and between group B and C 62% and 63%, respectively. The significant decrease of %IgG1 in total serum IgG is able to distinguish patients with breast cancer of more than 5 mm in diameter from healthy controls and patients with benign breast diseases. Finally, calculated posterior probabilities revealed that within certain concentration limits %IgG1 may provide predictive information with high xprobabilities.
Journal Fur Praktische Chemie-chemiker-zeitung | 1994
Waltraud Steinschifter; Wolfgang Stadlbauer
Journal of Heterocyclic Chemistry | 1994
Waltraud Steinschifter; Werner Fiala; Wolfgang Stadlbauer
European Journal of Organic Chemistry | 2008
Appasaheb B. Ahvale; Hana Prokopcová; Jana Šefčovičová; Waltraud Steinschifter; Anna E. Täubl; Georg Uray; Wolfgang Stadlbauer
Journal of Biochemical and Biophysical Methods | 1997
R. Horejsi; G. Kollenz; Franz Dachs; H.M. Tillian; K. Schauenstein; E. Schauenstein; Waltraud Steinschifter
European Journal of Cancer | 1998
L Kornberger; E. Schauenstein; H. Rabl; Waltraud Steinschifter; Willibald Estelberger; Konrad Schauenstein; Michael Smola