Wanda Chan | Researchain

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Featured researches published by Wanda Chan.

Assay and Drug Development Technologies | 2003

A β-Lactamase-Dependent Gal4-Estrogen Receptor β Transactivation Assay for the Ultra-High Throughput Screening of Estrogen Receptor β Agonists in a 3,456-Well Format

Norbert T. Peekhaus; Marc Ferrer; Tina Chang; Oleg Kornienko; Jonathan Schneeweis; Todd Smith; Ira Hoffman; Lyndon J. Mitnaul; Jayne Chin; Paul Fischer; Tim A. Blizzard; Elizabeth T. Birzin; Wanda Chan; James Inglese; Berta Strulovici; Susan P. Rohrer; James M. Schaeffer

Estrogen action is mediated via two estrogen receptor (ER) subtypes, ERα and ERβ. Selective ER modulators with balanced high affinity for ERα and ERβ have been developed as therapeutics for the tre...

Journal of Medicinal Chemistry | 2004

Estrogen receptor ligands. II. Discovery of benzoxathiins as potent, selective estrogen receptor alpha modulators.

Seongkon Kim; Jane Y. Wu; Elizabeth T. Birzin; Katalin Frisch; Wanda Chan; Lee-Yuh Pai; Yi Tien Yang; Ralph T. Mosley; Paula M. D. Fitzgerald; Nandini Sharma; Johanna Dahllund; Ann-Gerd Thorsell; Frank P. DiNinno; Susan P. Rohrer; James M. Schaeffer; Milton L. Hammond

Bioorganic & Medicinal Chemistry Letters | 2005

Estrogen receptor ligands. Part 9: Dihydrobenzoxathiin SERAMs with alkyl substituted pyrrolidine side chains and linkers.

Timothy A. Blizzard; Frank P. DiNinno; Jerry D. Morgan; Helen Chen; Jane Y. Wu; Seongkon Kim; Wanda Chan; Elizabeth T. Birzin; Yi Tien Yang; Lee-Yuh Pai; Paula M. D. Fitzgerald; Nandini Sharma; Ying Li; Zhoupeng Zhang; Edward C. Hayes; Carolyn DaSilva; Wei Tang; Susan P. Rohrer; James M. Schaeffer; Milton L. Hammond

Bioorganic & Medicinal Chemistry Letters | 2004

Estrogen receptor ligands. Part 1: The discovery of flavanoids with subtype selectivity

Helen Chen; Kevin D. Dykstra; Elizabeth T. Birzin; Katalin Frisch; Wanda Chan; Yi T. Yang; Ralph T. Mosley; Frank P. DiNinno; Susan P. Rohrer; James M. Schaeffer; Milton L. Hammond

Bioorganic & Medicinal Chemistry Letters | 2005

Estrogen receptor ligands. Part 10: Chromanes: old scaffolds for new SERAMs.

Qiang Tan; Timothy A. Blizzard; Jerry D. Morgan; Elizabeth T. Birzin; Wanda Chan; Yi Tien Yang; Lee-Yuh Pai; Edward C. Hayes; Carolyn DaSilva; Sudha Warrier; Joel B. Yudkovitz; Hilary A. Wilkinson; Nandini Sharma; Paula M. D. Fitzgerald; Susan Li; Lawrence F. Colwell; John E. Fisher; Sharon Adamski; Alfred A. Reszka; Donald Kimmel; Frank P. DiNinno; Susan P. Rohrer; Leonard P. Freedman; James M. Schaeffer; Milton L. Hammond

Bioorganic & Medicinal Chemistry Letters | 2005

Estrogen receptor ligands. Part 13: Dihydrobenzoxathiin SERAMs with an optimized antagonist side chain

Timothy A. Blizzard; Frank P. DiNinno; Helen Chen; Seongkon Kim; Jane Y. Wu; Wanda Chan; Elizabeth T. Birzin; Yi Tien Yang; Lee-Yuh Pai; Edward C. Hayes; Carolyn DaSilva; Susan P. Rohrer; James M. Schaeffer; Milton L. Hammond

Bioorganic & Medicinal Chemistry Letters | 2005

Estrogen receptor ligands. Part 11: Synthesis and activity of isochromans and isothiochromans

Jian Liu; Elizabeth T. Birzin; Wanda Chan; Yi Tien Yang; Lee-Yuh Pai; Carolyn DaSilva; Edward C. Hayes; Ralph T. Mosley; Frank P. DiNinno; Susan P. Rohrer; James M. Schaeffer; Milton L. Hammond

Bioorganic & Medicinal Chemistry Letters | 2004

Estrogen receptor ligands. Part 3: The SAR of dihydrobenzoxathiin SERMs.

Helen Chen; Seongkon Kim; Jane Y. Wu; Elizabeth T. Birzin; Wanda Chan; Yi Tien Yang; Johanna Dahllund; Frank P. DiNinno; Susan P. Rohrer; James M. Schaeffer; Milton L. Hammond

Bioorganic & Medicinal Chemistry Letters | 2007

Estrogen receptor ligands. Part 16: 2-Aryl indoles as highly subtype selective ligands for ERα

Kevin D. Dykstra; Liangqin Guo; Elizabeth T. Birzin; Wanda Chan; Yi Tien Yang; Edward C. Hayes; Carolyn DaSilva; Lee-Yuh Pai; Ralph T. Mosley; Bryan Kraker; Paula M. D. Fitzgerald; Frank P. DiNinno; Susan P. Rohrer; James M. Schaeffer; Milton L. Hammond

Bioorganic & Medicinal Chemistry Letters | 2004

Estrogen receptor ligands. Part 7: Dihydrobenzoxathiin SERAMs with bicyclic amine side chains.

Timothy A. Blizzard; Frank P. DiNinno; Jerry D. Morgan; Helen Chen; Jane Y. Wu; Candido Gude; Seongkon Kim; Wanda Chan; Elizabeth T. Birzin; Yi Tien Yang; Lee-Yuh Pai; Zhoupeng Zhang; Edward C. Hayes; Carolyn DaSilva; Wei Tang; Susan P. Rohrer; James M. Schaeffer; Milton L. Hammond

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