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Dive into the research topics where Wang En-si is active.

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Featured researches published by Wang En-si.


Chemical Research in Chinese Universities | 2017

Synthesis and Biological Activity of Imidazo[4,5-c]quinoline Derivatives as PI3K/mTOR Inhibitors

Li Yanjie; Zhang Xingmin; Niu Shengxiu; Zhao Yanping; Yang Lijuan; Shao Xiaowei; Wang En-si

A series of imidazo[4,5-c]quinoline derivatives(12a—12m) was synthesized with 2-amino-5-bromobenzoic acid and 4-nitrophenylacetonitrile as starting materials, 6-bromo-4-chloro-3-nitroquinoline as intermediate and Suzuki reaction and closure of the imidazolinone ring with triphosgene as key steps. The structures of the key intermediate and target compounds were confirmed by means of 1H NMR, 13C NMR and HRMS. These compounds show an interesting kinase profile as dual PI3K/mTOR tool compounds.


Archive | 2015

IMIDAZOLONE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF

Zhang Xingmin; Wang En-si; Niu Shengxiu; Guo Jing; Dai Zhuolin; Zheng Nan; Du Zhenjian; Ji Qi; Li Qinyan; Liang Tie


Bioorganic & Medicinal Chemistry Letters | 2011

Synthesis and bioactivity of new Finasteride conjugate

Zhao Shuang; Wu Jiazhen; Yang Lijuan; Li Zhuo; Yu Dahai; Li Jinfeng; Yu Jing; Liang Yongtao; Wang En-si; Fang Xuexun


Journal of Jilin University(Science Edition) | 2008

Synthesis of a New Immunosuppressant FTY-720

Wang En-si


Archive | 2014

Imidazolone quinoline derivatives, and medicinal composition and use thereof

Zhang Xingmin; Wang En-si; Niu Shengxiu; Guo Jing; Dai Zhuolin; Zheng Nan; Du Zhenjian; Ji Qi; Li Qinyan; Liang Tie


Archive | 2012

Heterocyclic group contained amino-methanol derivative, its salt, its synthetic method and its use

Zhang Xingmin; Wang En-si; Guo Jing; Niu Shengxiu; Dai Zhuolin; Zheng Nan; Ji Liping; Wang Zhenfang; Liang Tie


Archive | 2016

KETONE DERIVATIVES OF IMIDAZOLES, PHARMACEUTICAL COMBINATIONS AND USES THEREOF

Zhang Xingmin; Ji Qi; Wang Lei; Gao Congmin; Wang En-si; Du Zhenjian; Gong Longlong; Chen Bo


Chemical Research in Chinese Universities | 2016

1,3,4 オキサジアゾールを含むアミノアルコールの合成と生物学的評価【Powered by NICT】

Wu Yi; Zhao Yanping; Guo Jing; Lu Haoze; Zheng Nan; Wang En-si


Archive | 2015

IMIDAZOLONE DERIVATIVES, PHARMCEUTICAL COMPOSITIONS AND USES THEREOF

Zhang Xingmin; Ji Qi; Wang Lei; Gao Congmin; Wang En-si; Du Zhenjian; Gong Longlong; Chen Bo


West China Journal of Pharmaceutical Sciences | 2012

Determination of related substances of Dutasteride by RP-HPLC

Wang En-si

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Li Jinfeng

Sun Yat-sen University

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