Wang Guanquan

Preparation and properties of 117mSn(IV)-TTHMP in in-vitro and in small animals

In this work, TTHMP was synthesized and labelled with 117mSn. The preparation conditions, stability and lipophilicity of 117mSn(IV)-TTHMP were investigated. Biodistribution of the complex in rabbits and mice was studied. It was found that the quantity of TTHMP and pH value of the preparation solution had vital effects on the labeling yield of 117mSn(IV)-TTHMP. It was also found that 117mSn(IV)-TTHMP was hydrophilic and stable at room temperature and 37°C in open air. 117mSn(IV)-TTHMP showed unexpectedly high bone uptake and bone-to-blood ratio in the animals. This made it potentially useful as an reagent for skeletal scindgraphy and radiotherapy of bone tumors.