Wanlapa Teawsomboonkit
Mahidol University
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Publication
Featured researches published by Wanlapa Teawsomboonkit.
Asian Pacific Journal of Allergy and Immunology | 2013
Sirasuda Sommanus; Saowanee Kerddonfak; Wasu Kamchaisatian; Soamarat Vilaiyuk; Cherapat Sasisakulporn; Wanlapa Teawsomboonkit; Suwat Benjaponpitak
OBJECTIVE To study changes in immunological responses in patients with CMPA during symptomatic and asymptomatic episodes of cows milk protein tolerance status. METHODS 27 CMPA patients were enrolled and underwent diagnostic evaluation, including CM challenge test, skin prick test and specific IgE to CM. Blood samples were collected in two periods from those who became tolerant (n = 13) and those with persistent CMA (n = 14), in order to measure in vitro PBMC responses to cows milk protein (IL-10, IFN-γ, IL-5), IgG4 to β-lactoglobulin, casein, BLG-IgG4/IgE ratio and the CAS-IgG4/IgE ratio. RESULTS Seventy percent of CMPA patients in our study were male with a mean age at diagnosis of 8 months and mean age of onset of 3 months. The reaction time to CM ranged from within 7 minutes to within 14 days. Positive IgE-sensitization was defined as either a specific IgE to CM of more than 0.35 kUA/L (N=11) or SPTs positive for CM and/or fresh cows milk (N=20). Forty-eight percent of the patients (n = 13) could tolerate CM by 13.38 months (8-19 months). Mean specific-IgE levels to CM were 4.1 kUA/L (range 0.35-14.3 kUA/L). Determination of the cytokine (IL-10, IFN-γ, IL-5) response to BLG revealed significantly higher IL-10 levels during the tolerance phase (212.93 vs 142.46 pg/ml, P = .011). There was a significant increase in BLG-IgG4 and the BLG-IgG4/IgE ratio in the tolerance phase when compared to the symptomatic phase. CONCLUSIONS IL-10, BLG-IgG4 and the BLG-IgG4/IgE ratio were higher in CMPA patients during the tolerance phase compared to the symptomatic phase.
Asian Pacific Journal of Allergy and Immunology | 2013
Nualnapa Anantasit; Soamarat Vilaiyuk; Wasu Kamchaisatian; Wasu Supakornthanasarn; Cherapat Sasisakulporn; Wanlapa Teawsomboonkit; Suwat Benjaponpitak
BACKGROUND Nasal provocation tests (NPTs) are indicated in confirming the diagnosis of allergic rhinitis if the clinical history, skin tests or sIgE are inconclusive. NPTs are time- consuming, technically difficult and expensive to perform. Consequently, conjunctival provocation tests (CPTs), which are easier, cheaper and safer should be considered as an alternative method. No recent study has compared CPTs with NPTs in allergic rhinitis children. OBJECTIVE To compare CPTs with NPTs in allergic rhinitis children with house dust mite sensitization METHODS Fifty-five children with allergic rhinitis were included. Thirty-six children had positive skin prick tests (SPTs) to Dermatophagoides pteronyssinus (Dp). NPTs were performed by spraying 0.1 ml of Dp extract with concentrations of 50, 200 and 500 AU/ml to each nostril at 15 minute interval. The clinical symptom scores, anterior rhinomanometry results and nasal peak flow testing were performed to assess the responses. For CPTs, 0.1 ml of the same concentration of allergen extract was droppedinto one eye and the control solution was dropped into the other. The responses were assessed by clinical symptom scores. The tests were stopped when the subject reported a positive response, or continued to the maximum concentration. RESULTS The sensitivity, specificity, positive predictive value, negative predictive value and accuracy of CPT compared with NPT are 97.1% (84.7-99.9), 90.5% (69.6-98.8), 94.3% (80.8-99.3), 95% (75.1-99.9) and 94.5 (84.9-98.9), respectively in all patients. Among individual allergic rhinitis subjects the sensitivity, specificity, PPV and NPV are 100%. CONCLUSIONS CPT can be an alternative test for NPT in allergic rhinitis children with house dust mite sensitization, even if they do not have conjunctival symptoms.
Pediatrics International | 2010
Wiparat Manuyakorn; C. Direkwattanachai; Suwat Benjaponpitak; Wasu Kamchaisatian; Cherapat Sasisakulporn; Wanlapa Teawsomboonkit
Background: Dry powder inhalers (DPI) are alternative devices for delivering medication for treatment of asthma. The amount of drug delivery to the lungs is directly influenced by peak inspiratory flow rate (PIFR). A minimum PIFR of −30 L/min is needed for the Turbuhaler and Accuhaler.
Asian Pacific Journal of Allergy and Immunology | 2010
Saowanee Kerddonfak; Wiparat Manuyakorn; Wasu Kamchaisatian; Cherapat Sasisakulporn; Wanlapa Teawsomboonkit; Suwat Benjaponpitak
Asian Pacific Journal of Allergy and Immunology | 2011
Kasalong Rakkhong; Wasu Kamchaisatian; Soamarat Vilaiyuk; Cherapat Sasisakulporn; Wanlapa Teawsomboonkit; Prapaporn Pornsuriyasak; Suwat Benjaponpitak
The Journal of Allergy and Clinical Immunology | 2012
O. Luecha; Wasu Kamchaisatian; Soamarat Vilaiyuk; Wiparat Manuyakorn; C. Sasisakunporn; Wanlapa Teawsomboonkit; Suwat Benjaponpitak
The Journal of Allergy and Clinical Immunology | 2009
Saowanee Kerddonfak; Wiparat Manuyakorn; Wasu Kamchaisatian; Cherapat Sasisakulporn; Wanlapa Teawsomboonkit; Suwat Benjaponpitak
The Journal of Allergy and Clinical Immunology | 2016
Wiparat Manuyakorn; Suwat Benjaponpitak; Wasu Kamchaisatian; Cherapat Sasisakulporn; Wanlapa Teawsomboonkit
The Journal of Allergy and Clinical Immunology | 2013
Savitree Padungpak; Wiparat Manuyakorn; Wasu Kamchaisatian; Suwat Benjaponpitak; Soamarat Vilaiyuk; Cherapat Sasisakulporn; Wanlapa Teawsomboonkit
The Journal of Allergy and Clinical Immunology | 2013
Ratchaneewan Sinitkul; Suporn Treepongkaruna; Sumate Teeraratkul; Wasu Kamchaisatian; Wiparat Manuyakorn; Soamarat Vilaiyuk; Cherapat Sasisakulporn; Wanlapa Teawsomboonkit; Suwat Benjaponpitak