Warren M. Jackman

Development and Validation of an ECG Algorithm for Identifying Accessory Pathway Ablation Site in Wolff-Parkinson-White Syndrome

ECG Localization of Accessory AV Pathways. Introduction: Delta wave morphology correlates with the site of ventricular insertion of accessory AV pathways. Because lesions due to radiofrequency (RF) current are small and well defined, it may allow precise localization of accessory pathways. The purpose of this study was to use RF catheter ablation to develop an ECG algorithm to predict accessory pathway location.

Focal Atrial Fibrillation: Experimental Evidence for a Pathophysiologic Role of the Autonomic Nervous System

Focal AF and Autonomic Nerves. Introduction: Focal paroxysmal atrial fibrillation (AF) was shown recently to originate in the pulmonary veins (PVs) and superior vena cava (SVC). In the present study, we describe an animal model in which local high‐frequency electrical stimulation produces focal atrial activation and AF/AT (atrial tachycardia) with electrogram characteristics consistent with clinical reports.

Localization of Left Atrial Ganglionated Plexi in Patients with Atrial Fibrillation

Background. The intrinsic cardiac autonomic nervous system (ICANS), which forms a neural network, has been shown to be a critical element responsible for the initiation and maintenance of atrial fibrillation (AF). We developed a technique to localize and ablate the ganglionated plexi (GP), which serves as the “integration centers” of the ICANS.

Autonomic Mechanism to Explain Complex Fractionated Atrial Electrograms (CFAE)

Objective:u2002To simulate complex fractionated atrial electrograms (CFAE) during sustained atrial fibrillation (AF) in experimental animals.

Gradients of atrial refractoriness and inducibility of atrial fibrillation due to stimulation of ganglionated plexi.

Introduction. The mechanism(s) whereby atrial ectopy induces atrial fibrillation (AF) is still poorly understood.

Low‐Level Vagosympathetic Nerve Stimulation Inhibits Atrial Fibrillation Inducibility: Direct Evidence by Neural Recordings from Intrinsic Cardiac Ganglia

Intrinsic Cardiac Ganglia Activity Inhibited by Low‐Level Vagal Stimulation.u2002Introduction: We hypothesized that low‐level vagosympathetic stimulation (LL‐VNS) can suppress atrial fibrillation (AF) by inhibiting the activity of the intrinsic cardiac autonomic nervous system (ICANS).

Comparison of Cryothermia and Radiofrequency Current in Safety and Efficacy of Catheter Ablation within the Canine Coronary Sinus Close to the Left Circumflex Coronary Artery

Introduction: A canine model was used to compare cryoablation and radiofrequency ablation (RFA) within the coronary sinus (CS) in the ability to create a transmural CS myocardial (Trans‐CSM) lesion and risk of coronary artery stenosis.

Autonomic Mechanism for Complex Fractionated Atrial Electrograms: Evidence by Fast Fourier Transform Analysis

Introduction: The mechanism(s) underlying complex fractionated atrial electrograms (CFAE) is not well understood. We hypothesized that CFAE may be caused by enhanced activity of the intrinsic cardiac autonomic nervous system.

Low-level right vagal stimulation: anticholinergic and antiadrenergic effects.

Right Vagal Stimulation Suppresses Atrial Fibrillation. Introduction: We sought to extend the use of low‐level vagal stimulation by applying it only to the right vagus nerve (LL‐RVS) to suppress atrial fibrillation (AF).

An Acute Model for Atrial Fibrillation Arising from a Peripheral Atrial Site: Evidence for Primary and Secondary Triggers

Background: We previously demonstrated that acetylcholine (Ach) injected into cardiac ganglionated plexi (GP) causes pulmonary vein (PV) ectopy initiating atrial fibrillation (AF).