Wataru Jomen
Sapporo Medical University
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Publication
Featured researches published by Wataru Jomen.
Journal of Medical Case Reports | 2016
Soushi Ibata; Tsutomu Sato; Kohichi Takada; Ayumi Tatekoshi; Akari Hashimoto; Yusuke Kamihara; Wataru Jomen; Hiroto Horiguchi; Kaoru Ono; Kazuyuki Murase; Satoshi Iyama; Koji Miyanishi; Yasushi Sato; Rishu Takimoto; Masayoshi Kobune; Junji Kato
BackgroundSystemic capillary leak syndrome is a rare condition characterized by episodic attacks of hypovolemia due to systemic capillary hyperpermeability, which results in profound hypotension and edema. Although the implication of vascular endothelial growth factor, angiopoietin-2, and C-X-C motif chemokine 10 has been suggested, the pathogenesis of systemic capillary leak syndrome remains unclear. In this report, we describe a case of systemic capillary leak syndrome in which serum isoform D of vascular endothelial growth factor was elevated. To the best of our knowledge, this is the first reported case of systemic capillary leak syndrome in which isoform D of vascular endothelial growth factor is suggested as the plausible biomarker.Case presentationA 41-year-old Japanese man was transferred to our emergency department. He was hypotensive, tachycardic, and edematous over the trunk and all four limbs. He received aggressive intravenous fluid therapy and underwent fasciotomy of the right forearm to prevent muscle necrosis. A diagnosis of systemic capillary leak syndrome was suspected. The presence of serum monoclonal immunoglobulin G and κ light chain supported this diagnosis. Prevention of hypotensive crises was unsuccessfully attempted with theophylline, intravenous immunoglobulin, high-dose dexamethasone, bortezomib, melphalan, and prednisolone; however, the patient’s attacks dramatically disappeared after the introduction of thalidomide. The serum of the patient was stored soon after the onset of hypotensive crisis and analyzed to profile possible mediators responsible for the capillary leak. The concentration of vascular endothelial growth factor, angiopoietin-2, and C-X-C motif chemokine 10 were all within normal ranges. Meanwhile, we found that isoform D of vascular endothelial growth factor was elevated, which was normalized after the introduction of thalidomide.ConclusionsIn our patient, isoform D of vascular endothelial growth factor (instead of vascular endothelial growth factor) may have been a causative factor of hypotensive crises, since isoform D contributes to vascular endothelial growth factor receptor-2 signaling, which is the major mediator of the permeability-enhancing effects of vascular endothelial growth factor. We suggest the measurement of isoform D of vascular endothelial growth factor in patients with systemic capillary leak syndrome in whose serum vascular endothelial growth factor is not elevated.
The Japanese journal of clinical hematology | 2014
Yamada M; Hiroyuki Kuroda; Masahiro Yoshida; Wataru Jomen; Tomoyuki Abe; Sakurai T; Fujii S; Masahiro Maeda; Miri Fujita; Kazuo Nagashima; Matsuno T; Masanori Sato; Junji Kato
Blood | 2014
Hiroto Horiguchi; Masayoshi Kobune; Shohei Kikuchi; Wataru Jomen; Kazuyuki Murase; Soushi Ibata; Satoshi Iyama; Tsutomu Sato; Yusuke Kamihara; Koji Miyanishi; Yasushi Sato; Tsuyoshi Hayashi; Rishu Takimoto; Junji Kato
The Japanese journal of clinical hematology | 2013
Hiroyuki Kuroda; Ishikawa K; Wataru Jomen; Masahiro Yoshida; Yamada M; Tomoyuki Abe; Sakurai T; Fujii S; Masahiro Maeda; Matsuno T; Masanori Sato; Miri Fujita; Kazuo Nagashima; Junji Kato
The Japanese journal of clinical hematology | 2013
Hiroyuki Kuroda; Tomoyuki Abe; Wataru Jomen; Masahiro Yoshida; Matsuno T; Masanori Sato; Yamada M; Sakurai T; Fujii S; Masahiro Maeda; Miri Fujita; Kazuo Nagashima; Kazuyuki Murase; Junji Kato
Clinical Journal of Gastroenterology | 2011
Hirotoshi Ishiwatari; Tsuyoshi Hayashi; Makoto Yoshida; Wataru Jomen; Koji Miyanishi; Tsutomu Sato; Yasushi Sato; Rishu Takimoto; Masayoshi Kobune; Junji Kato
Kanzo | 2018
Wataru Jomen; Rie Okutsu; Tomoyuki Masuda
Blood | 2016
Shogo Miura; Masayoshi Kobune; Soushi Ibata; Yoshida M; Satoshi Iyama; Tsutomu Sato; Kazuyuki Murase; Kohichi Takada; Kaoru Ono; Akari Hashimoto; Ayumi Tatekoshi; Yusuke Kamihara; Yusuke Sugama; Wataru Jomen; Shohei Kikuchi; Hiroshi Ikeda; Hiroto Horiguchi; Yutaka Kawano; Koji Miyanishi; Hiroyuki Kuroda; Masahiro Maeda; Junji Kato
The Japanese journal of clinical hematology | 2014
Wataru Jomen; Hiroyuki Kuroda; Matsuno T; Masanori Sato; Yamada M; Tomoyuki Abe; Sakurai T; Fujii S; Masahiro Maeda; Miri Fujita; Junji Kato; Nojiri S
The Japanese journal of clinical hematology | 2014
Masanori Sato; Hiroyuki Kuroda; Masahiro Yoshida; Makoto Usami; Tomoyuki Abe; Sakurai T; Fujii S; Masahiro Maeda; Miri Fujita; Yusuke Kanari; Matsuno T; Wataru Jomen; Junji Kato