Wei-Dong Meng

Synthesis and anticancer effect of chrysin derivatives

A series of chrysin derivatives, prepared by alkylation, halogenation, nitration, methylation, acetylation and trifluoromethylation, were tested in vitro against human gastric adenocarcinoma cell line (SGC-7901) and colorectal adenocarcinoma (HT-29) cells. Among these derivatives of chrysin, 5,7-dimethoxy-8-iodochrysin 3 and 8-bromo-5-hydroxy-7-methoxychrysin 11 have the strongest activities against SGC-7901 and HT-29 cells, respectively. 5,7-Dihydroxy-8-nitrochrysin 12 were found to have strong activities against both SGC-7901 and HT-29 cells.

Fluorinated nucleosides as antiviral and antitumor agents.

The synthesis of nucleosides and analogues with fluoride modifications on the surgar moiety are reviewed, and their biological activities as potential antiviral and anti-tumor agents are also discussed.

Synthesis of 4,6-disubstituted pyrimidines via Suzuki and Kumada coupling reaction of 4,6-dichloropyrimidine

A series of 4,6-disubstituted pyrimidines were synthesized via Suzuki and Kumada coupling reaction of 4,6-dichloropyrimidine.

Water and Oil Repellent and Durable Press Finishes for Cotton Based on a Perfluoroalkyl-Containing Multi-Epoxy Compound and Citric Acid

A novel perfluoroalkyl-containing multi-epoxy compound (PFME), designed and syn thesized in our laboratory, is applied to cotton fabrics by the pad-dry-cure process to give durable water and oil repellency by developing permanent covalent bonds to the textile substrate. The specimens pretreated by citric acid are further treated with PFME. The dual finished cotton shows both durable water and oil repellent appearances and durable press properties. The optimum treatment conditions for the dual finishing are discussed.

Synthesis and Application of Novel Aqueous Anionic Polyurethane as a Durable Press Finishing Agent of Cotton Fabrics

In this study, a novel aqueous anionic polyurethane (NAPU) modified with silane coupling agent and maleic anhydride was synthesized. The efficiency of NAPU as a durable press finishing agent of cotton fabrics was examined, and compared with other crosslinking agents such as modified dimethyloldihydroxyethyleneurea (SDP) and citric acid (CA). The optimum processing conditions for the treatment of cotton fabrics with NAPU were also studied.

A Novel Perfluoroalkyl-Containing Bisulfite Adduct of Polyisocyanate: Synthesis and Finishing of Cotton Fabrics

A perfluoroalkyl-containing diol (F-diol) is introduced into polyisocyanate, and novel bifunctional perfluoroalkyl-containing bisulfite adduct of polyisocyanate (FBAP) is successfully prepared after blocking with sodium metabisulfite. FBAP is applied to cotton fabrics by a pad-dry-cure process. The treated fabrics show good durable press and water and oil repellent properties: the dry wrinkle recovery angle reaches 210° and the water and oil repellent ratings are 100 and 6, respectively. After 10 washing cycles, the water repellent rating is still 90 and the oil repellent rating is 5.

Applying a Bisulfite Adduct of Polyisocyanate to Cotton Fabrics as a Durable Press Finishing Agent

The bisulfite adduct of polyisocyanate (BAP), designed and synthesized in our laboratory, is applied to cotton fabrics as a durable press finishing agent. The dry wrinkle recovery angles of the fabrics are increased by treatment with BAP alone, but the maximum attainable value can only reach the range of 180°-190°, which is less efficient than with modified dimethyloldihydroxyethyleneurea (266°) and citric acid (231°). In order to obtain high performance fabrics, we attempt to combine BAP with modified dimethyloldihydroxyethyleneurea or CA for cotton fabrics as durable press finishing agents. The fabrics treated with 4.0% BAP and 4.5% modified dimethyloldihydroxyethyleneurea in a single bath give satisfactory durable press performance with improved tensile and tear strength and a little-changed whiteness index. Nonformaldehyde fabrics with good durable press performance are produced by treatment with 4.0% BAP in combination with 7% citric acid (CA) under conditions of drying 3 minutes at 80°C and curing 2 minutes at 170°C with sodium hypophosphite as a curing catalyst.

Palladium-catalyzed Heck-type reaction of secondary trifluoromethylated alkyl bromides

An efficient palladium-catalyzed Heck-type reaction of secondary trifluoromethylated alkyl bromides has been developed. The reaction proceeds under mild reaction conditions with high efficiency and excellent functional group tolerance, even towards formyl and hydroxy groups. Preliminary mechanistic studies reveal that a secondary trifluoromethylated alkyl radical is involved in the reaction.