Wei-Wei Liu

Synthesis, crystal structures, and biological activity of zinc(II) complexes derived from 2-amino-1,3,4-thiadiazole derivatives

ABSTRACT Two new similar zinc(II) complexes, [ZnCl2L12] and [ZnCl2L22], derived from the 2-amino-1,3,4-thiadiazole derivatives, were prepared and structurally characterized by X-ray diffraction. The Zn atom in each complex has a tetrahedral coordination and is coordinated by two N atoms of the ligands and two Cl atoms. The urease inhibitory activities of the complexes and the ligands were evaluated.

2,5-Bis[(3-hy­droxy­prop­yl)amino]-1,4-benzoquinone monohydrate

The title compound, C12H18N2O4·H2O, was obtained as a product of the reaction of hydroquinone with n-propanol amine. The compound crystallizes as a monohydrate, integrating water into its hydrogen-bonded network. Each diaminoquinone moiety forms two centrosymmetric 10-membered rings through C=O⋯H—N bonds. The resulting bands along [102] are interlinked through hydroxy groups and water molecules into three-dimensional network. The chemically equivalent bond lengths in the diaminoquinone moiety exhibit a perceptible discrepancy [e.g. C=O bond lengths differ by 0.016 (2) Å], apparently as a result of asymmetric hydrogen bonding: one O atom serves as an acceptor of one hydrogen bond, whereas the other is an acceptor of two.

Dimeth-yl(2-oxo-2-phenyl-eth-yl)sulfanium bromide.

Single crystals of the title compound, C10H13OS+·Br−, were obtained from ethyl acetate/ethyl ether after reaction of acetophenone with hydrobromic acid and dimethylsulfoxide. The carbonyl group is almost coplanar with the neighbouring phenyl ring [O—C—C—C = 178.9 (2)°]. The sulfanium group shows a trigonal–pyramidal geometry at the S atom. The crystal structure is stabilized by C—H⋯Br hydrogen-bonding interactions. Weak π–π interactions link adjacent phenyl rings [centroid–centroid distance = 3.946 (2) Å].

2-(2-Chloro-3-quinol-yl)-3-phenyl-thia-zolidin-4-one.

In the title compound, C18H13ClN2OS, the thiazolidinone ring is slightly distorted and adopts a envelope conformation. The basal plane is nearly perpendicular to the quinoline ring, forming a dihedral angle of 86.1 (1)°, and makes a dihedral angle of 14.9 (1)° to the benzene ring. The benzene ring is also nearly perpendicular to the quinoline ring, forming a dihedral angle of 89.4 (1)°. In the crystal, non-classical C—H⋯O and C—H⋯N hydrogen bonds link the molecules, forming polymers along b.