Weiling He

miR-124 inhibits cell proliferation in gastric cancer through down-regulation of SPHK1†

SPHK1 expression is elevated in gastric cancer and is associated with shorter survival times for patients. However, the molecular mechanism of SPHK1 up‐regulation in gastric cancer remains unclear. In the present study, we report that miR‐124 down‐regulated SPHK1 expression by directly targeting its 3′‐untranslated region (3′‐UTR) and that miR‐124 expression was inversely correlated with SPHK1 expression in gastric cancer samples. Furthermore, we demonstrated that, similar to the effect of silencing SPHK1, up‐regulation of miR‐124 markedly inhibited proliferation and tumourigenicity of gastric cancer cells both in vitro and in vivo. This was found to be mechanistically associated with induction of cyclin‐dependent kinase inhibitors p21

Fast-Track Surgery Improves Postoperative Clinical Recovery and Immunity After Elective Surgery for Colorectal Carcinoma: Randomized Controlled Clinical Trial

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Astrocyte elevated gene-1(AEG-1) induces epithelial-mesenchymal transition in lung cancer through activating Wnt/β-catenin signaling

and p27

Lymphatic endothelial cell-secreted CXCL1 stimulates lymphangiogenesis and metastasis of gastric cancer.

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miR-494 acts as an anti-oncogene in gastric carcinoma by targeting c-myc

, enhancement of the transcriptional activity of FOXO1 and suppression of AKT activity. Moreover, we showed that the re‐introduction of SPHK1 (without the 3′‐UTR), but not with the 3′‐UTR, could abrogate the miR‐124‐mediated induction of p21

Abnormal expression of E-cadherin in tumor cells is associated with poor prognosis of gastric carcinoma

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Combined evaluation of centromere protein H and Ki-67 as prognostic biomarker for patients with gastric carcinoma

and p27

Detecting ALK-rearrangement of CTC enriched by nanovelcro chip in advanced NSCLC patients

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The prognostic value of lymph nodes dissection number on survival of patients with lymph node-negative gastric cancer.

, as well as rescue the miR‐124‐induced proliferation inhibition. Together, these results suggest that miR‐124 has an important role in the suppression of gastric cancer and presents a novel mechanism of miRNA‐mediated SPHK1 expression in cancer cells. Copyright

Loss expression of PHLPP1 correlates with lymph node metastasis and exhibits a poor prognosis in patients with gastric cancer

BackgroundFew clinical studies or randomized clinical trial results have reported the impact of fast-track surgery on human immunity. This study aimed to investigate the clinical and immune impact of fast-track surgery in colorectal cancer patients undergoing elective open surgery.MethodsA controlled randomized clinical trial was conducted from November 2008 to January 2009 with a 1-month postdischarge follow-up. A total of 70 patients with colorectal carcinoma requiring colorectal resection were randomized into two groups: a fast-track group (35 cases) and a conventional care group (35 cases). All included patients underwent elective open colorectal resection with combined tracheal intubation and general anesthesia. Clinical parameters and markers of immune function were evaluated in both groups postoperatively.ResultsIn all, 62 patients completed the study: 32 in the fast-track group and 30 in the conventional care group. Our findings revealed a significantly shorter postoperative hospital stay and faster return of gastrointestinal function in patients undergoing fast-track rehabilitation. In addition, we found a quicker response of white blood cells in the fast-track group than in the conventional care group. We also found that blood levels of globulin, immunoglobulin G, and complement 4 on postoperative day 3 were higher in the fast-track group than in the conventional care group.ConclusionsFast-track surgery accelerates clinical recovery and improves postoperative immunity after elective open surgery for colorectal carcinoma.