Weishan Chang

Contrast enhancement for portal images by combination of subtraction and reprojection processes for Compton scattering

Abstract For patient setup of the IGRT technique, various imaging systems are currently available. MV portal imaging is performed in identical geometry with the treatment beam so that the portal image provides accurate geometric information. However, MV imaging suffers from poor image contrast due to larger Compton scatter photons. In this work, an original image processing algorithm is proposed to improve and enhance the image contrast without increasing the imaging dose. Scatter estimation was performed in detail by MC simulation based on patient CT data. In the image processing, scatter photons were eliminated and then they were reprojected as primary photons on the assumption that Compton interaction did not take place. To improve the processing efficiency, the dose spread function within the EPID was investigated and implemented on the developed code. Portal images with and without the proposed image processing were evaluated by the image contrast profile. By the subtraction process, the image contrast was improved but the EPID signal was weakened because 15.2% of the signal was eliminated due to the contribution of scatter photons. Hence, these scatter photons were reprojected in the reprojection process. As a result, the tumor, bronchi, mediastinal space and ribs were observed more clearly than in the original image. It was clarified that image processing with the dose spread functions provides stronger contrast enhancement while maintaining a sufficient signal‐to‐noise ratio. This work shows the feasibility of improving and enhancing the contrast of portal images.

Evaluation of beam hardening and photon scatter by brass compensator for IMRT

When a brass compensator is set in a treatment beam, beam hardening may take place. This variation of the energy spectrum may affect the accuracy of dose calculation by a treatment planning system and the results of dose measurement of brass compensator intensity modulated radiation therapy (IMRT). In addition, when X-rays pass the compensator, scattered photons are generated within the compensator. Scattered photons may affect the monitor unit (MU) calculation. In this study, to evaluate the variation of dose distribution by the compensator, dose distribution was measured and energy spectrum was simulated using the Monte Carlo method. To investigate the influence of beam hardening for dose measurement using an ionization chamber, the beam quality correction factor was determined. Moreover, to clarify the effect of scattered photons generated within the compensator for the MU calculation, the head scatter factor was measured and energy spectrum analyses were performed. As a result, when X-rays passed the brass compensator, beam hardening occurred and dose distribution was varied. The variation of dose distribution and energy spectrum was larger with decreasing field size. This means that energy spectrum should be reproduced correctly to obtain high accuracy of dose calculation for the compensator IMRT. On the other hand, the influence of beam hardening on kQ was insignificant. Furthermore, scattered photons were generated within the compensator, and scattered photons affect the head scatter factor. These results show that scattered photons must be taken into account for MU calculation for brass compensator IMRT.

Correction of stopping power and LET quenching for radiophotoluminescent glass dosimetry in a therapeutic proton beam

To measure the absorbed dose to water D w in proton beams using a radiophotoluminescent glass dosimeter (RGD), a method with the correction for the change of the mass stopping power ratio (SPR) and the linear energy transfer (LET) dependence of radiophotoluminescent efficiency [Formula: see text] is proposed. The calibration coefficient in terms of D w for RGDs (GD-302M, Asahi Techno Glass) was obtained using a 60Co γ-ray. The SPR of water to the RGD was calculated by Monte Carlo simulation, and [Formula: see text] was investigated experimentally using a 70 MeV proton beam. For clinical usage, the residual range R res was used as a quality index to determine the correction factor for the beam quality [Formula: see text] and the LET quenching effect of the RGD [Formula: see text]. The proposed method was evaluated by measuring D w at different depths in a 200 MeV proton beam. For both non-modulated and modulated proton beams, [Formula: see text] decreases rapidly where R res is less than 4 cm. The difference in [Formula: see text] between a non-modulated and a modulated proton beam is less than 0.5% for the R res range from 0 cm to 22 cm. [Formula: see text] decreases rapidly at a LET range from 1 to 2 keV µm-1. In the evaluation experiments, D w using RGDs, [Formula: see text] showed good agreement with that obtained using an ionization chamber and the relative difference was within 3% where R res was larger than 1 cm. The uncertainty budget for [Formula: see text] in a proton beam was estimated to investigate the potential of RGD postal dosimetry in proton therapy. These results demonstrate the feasibility of RGD dosimetry in a therapeutic proton beam and the general versatility of the proposed method. In conclusion, the proposed methodology for RGDs in proton dosimetry is applicable where R res  >  1 cm and the RGD is feasible as a postal audit dosimeter for proton therapy.

SU-F-T-175: Absorbed Dose Measurement Using Radiophotoluminescent Glass Dosimeter in Therapeutic Proton Beam

PURPOSE To measure the absorbed dose to water Dw in therapeutic proton beam with radiophotoluminescent glass dosimeter (RGD), a methodology was proposed. In this methodology, the correction factor for the LET dependence of radiophotoluminescent (RPL) efficiency and the variation of mass stopping power ratio of water to RGD (SPRw, RGD) were adopted. The feasibility of proposed method was evaluated in this report. METHODS The calibration coefficient in terms of Dw for RGDs (GD-302M, Asahi Techno Glass) was obtained using 60Co beam. The SPRw, RGD was calculated by Monte Carlo simulation toolkit Geant4. The LET dependence of RPL efficiency was investigated experimentally by using a 70 MeV proton beam at National Institute of Radiological Sciences. For clinical usage, the residual range Rres was used as a quality index to determine the correction factor for RPL efficiency. The proposed method was evaluated by measuring Dw at difference depth in the 200 MeV proton beam. RESULTS For both modulated and non-modulated proton beam, the SPRw, RGD increases more than 3 % where Rres are less than 1 cm. RPL efficiency decreases with increasing LET and it reaches 0.6 at LET of 10 keV µm-1 . Dw measured by RGD (Dw, RGD) shows good agreement with that measured by ionization chamber (Dw, IC) and the relative difference between Dw, RGD and Dw, IC are within 3 % where Rres is larger than 1 cm. CONCLUSION In this work, a methodology for using RGD in proton dosimetry was proposed and the SPRw, RGD and the LET dependence of RPL efficiency in therapeutic proton beam was investigated. The results revealed that the proposed method is useful for RGD in the dosimetry of proton beams.

SU-E-T-124: Feasubility Study of Absorbed Dose Estimation Using Radiophotoluminescence Glass Dosimeter for Proton Therapeutic Beam

Purpose: Ion chamber is one of the fewer detectors that can be used to measure absolute dose for protonbeam at present. However ion chamber is not proper for in vivo dose measurement as the large volume. Although a great number of studies reported on the in vivo dosimetry. But there is no study carried out on the topic for feasibility of the absolute dose measurement by radiophotoluminescence glass dosimeter (RGD) with the stopping power correction. The purpose of the study is to investigate the performance of RGD in the therapeuticprotonbeam by means of Monte Carlo simulation and experiments, and evaluate the feasibility of RGD for therapeuticprotonbeam. Methods: In this work, Monte Carlo simulation toolkit Geant4 was used to obtain the detailed information of dosimetric performance of the RGD. Firstly, the protonstopping power ratio of water to RGD (GD301, Asahi Techno Glass Co.) was calculated. Secondly, the beam modeling of protonbeam in Southern Tohoku Proton center was held and then absorbed dose and proton energy fluence in the RGD at different depth was calculated for acquiring the stopping power correction factors. Finally the stopping power correction factor calculated by Geant4 will be applied to the measured data for confirming the usefulness of stopping power correction and the usability of RGD for dose measurement in therapeuticprotonbeam. Results: The simulation results showed that the stopping power ratio of RGD to water increased with the decreasing energy. The measured data showed good agreement between ion chamber and RGD with stopping power correction except the region behind of Bragg peak. Conclusions: The experiment results revealed that the usefulness of stopping power correction for correct proton dose measurement using RGD. More research is needed for correct dose measurement around the deeper region of Bragg peak.