Wendy B. Young | Researchain

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Featured researches published by Wendy B. Young.

Bioorganic & Medicinal Chemistry Letters | 2006

Potent 4-amino-5-azaindole factor VIIa inhibitors

Huiyong Hu; Aleksandr Kolesnikov; Jennifer R. Riggs; Kieron E. Wesson; Robin Stephens; Ellen M. Leahy; William D. Shrader; Paul A. Sprengeler; Michael J. Green; Ellen Sanford; Margaret Nguyen; Erik Gjerstad; Ronnel Cabuslay; Wendy B. Young

Bioorganic & Medicinal Chemistry Letters | 2006

Factor VIIa inhibitors: Chemical optimization, preclinical pharmacokinetics, pharmacodynamics, and efficacy in an arterial baboon thrombosis model.

Wendy B. Young; Joyce Mordenti; Steven M. Torkelson; William D. Shrader; Aleksandr Kolesnikov; Roopa Rai; Liang Liu; Huiyong Hu; Ellen M. Leahy; Michael J. Green; Paul A. Sprengeler; Bradley A. Katz; Christine Yu; James W. Janc; Kyle Elrod; Ulla M. Marzec; Stephen R. Hanson

Bioorganic & Medicinal Chemistry Letters | 2006

Factor VIIa inhibitors: A prodrug strategy to improve oral bioavailability

Jennifer R. Riggs; Aleksandr Kolesnikov; John Hendrix; Wendy B. Young; William D. Shrader; Dange Vijaykumar; Robin Stephens; Liang Liu; Lin Pan; Joyce Mordenti; Michael J. Green; Juthamas Sukbuntherng

Journal of Molecular Biology | 2004

Dissecting and designing inhibitor selectivity determinants at the S1 site using an artificial Ala190 protease (Ala190 uPA).

Bradley A. Katz; Christine Luong; Joseph D. Ho; John R. Somoza; Erik Gjerstad; Jie Tang; Steven R. Williams; Erik Verner; Richard L. Mackman; Wendy B. Young; Paul A. Sprengeler; Hedy Chan; Kyle Mortara; James W. Janc; Mary E. McGrath

Bioorganic & Medicinal Chemistry Letters | 2006

Novel 5-azaindole factor VIIa inhibitors.

Jennifer R. Riggs; Huiyong Hu; Aleksandr Kolesnikov; Ellen M. Leahy; Kieron E. Wesson; William D. Shrader; Dange Vijaykumar; Troy A. Wahl; Zhiwei Tong; Paul A. Sprengeler; Michael J. Green; Christine Yu; Brad A. Katz; Ellen Sanford; Margaret Nguyen; Ronnel Cabuslay; Wendy B. Young

Bioorganic & Medicinal Chemistry Letters | 2006

Discovery of novel heterocyclic factor VIIa inhibitors

Roopa Rai; Aleksandr Kolesnikov; Paul A. Sprengeler; Steven M. Torkelson; Tony Ton; Bradley A. Katz; Christine Yu; John Hendrix; William D. Shrader; Robin Stephens; Ronnell Cabuslay; Ellen Sanford; Wendy B. Young

Bioorganic & Medicinal Chemistry Letters | 2006

Discovery of novel hydroxy pyrazole based factor IXa inhibitor.

Dange Vijaykumar; Paul A. Sprengeler; Michael Shaghafi; Jeffrey R. Spencer; Brad A. Katz; Christine Yu; Roopa Rai; Wendy B. Young; Brian Schultz; James W. Janc

Bioorganic & Medicinal Chemistry Letters | 2006

Factor VIIa inhibitors: gaining selectivity within the trypsin family.

William D. Shrader; Aleksandr Kolesnikov; Jana Burgess-Henry; Roopa Rai; John Hendrix; Huiyong Hu; Steve Torkelson; Tony Ton; Wendy B. Young; Bradley A. Katz; Christine Yu; Jie Tang; Ronnel Cabuslay; Ellen Sanford; James W. Janc; Paul A. Sprengeler

Bioorganic & Medicinal Chemistry Letters | 2006

Factor VIIa inhibitors: improved pharmacokinetic parameters.

Aleksandr Kolesnikov; Roopa Rai; Wendy B. Young; Joyce Mordenti; Liang Liu; Steven M. Torkelson; William D. Shrader; Ellen M. Leahy; Huiyong Hu; Erik Gjerstad; James W. Janc; Bradley A. Katz; Paul A. Sprengeler

Bioorganic & Medicinal Chemistry Letters | 2006

Small molecule inhibitors of plasma kallikrein.

Wendy B. Young; Roopa Rai; William D. Shrader; Jana Burgess-Henry; Huiyong Hu; Kyle Elrod; Paul A. Sprengeler; Bradley A. Katz; Juthamas Sukbuntherng; Joyce Mordenti

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