Wendy Brown

Imaging of tumors in the ankle and foot.

Common bone and soft tissue tumors in the foot and ankle are described in this article, and x-ray and magnetic resonance imaging characteristics are given. Ultrasound can be used for limited indications only, noting that ultrasound features are nonspecific. Of the bone and soft tissue tumors, approximately 7% occur in the foot and ankle. Soft tissue tumors are more common than bone tumors. Tumors of the foot and ankle are generally benign or nonneoplastic. Patients with suspected malignant lesions should be referred to a specialized bone tumor unit before biopsy.

Atypical EWSR1 FISH signal patterns in bone and soft tissue tumours:– diagnostic experience with 135 cases

Recurrent Ewing sarcoma breakpoint region 1 (EWSR1) gene rearrangements characterize a select group of bone and soft tissue tumours. In our routine diagnostic practice with fluorescence in‐situ hybridization (FISH), we have occasionally observed EWSR1 gene rearrangements in tumours not associated classically with EWSR1 translocations. This study aimed to review our institutional experience of this phenomenon and also to highlight the occurrence of unusual EWSR1 FISH signals (i.e. 5′ centromeric region or 3′ telomeric region signals) that do not fulfil the published diagnostic criteria for rearrangements.

Paget’s sarcoma of the patella

Paget’s sarcoma is a rare complication of Paget’s disease and isolated Paget’s disease of the patella is extremely rare. We describe a unique case of Paget’s sarcoma of the patella in a 69-year-old male farmer who had a remote history of a fracture in the same patella 40xa0years previously. In this case, imaging and pathogenesis of Paget’s disease of bone is described and factors implicated in the development of Paget’s disease in this patient are evaluated.

FISH analysis of selected soft tissue tumors: Diagnostic experience in a tertiary center

Fluorescence in situ hybridization (FISH) is an important ancillary tool for the classification of bone/soft tissue (BST) tumors. The aim of this study was to evaluate the contribution of FISH to the final classification of common BST entities in the molecular pathology department of the Royal Prince Alfred Hospital (RPAH), which is one of the most important referral centers for the management of sarcomas in Australia.