Wendy Wee

Characterization of antioxidant, antimicrobial, anticancer property and chemical composition of ficus deltoidea jack. leaf extract

Abstract This paper described antimicrobial, antioxidant and anticancer activities of Ficus deltoidea Jack. leaf extract as well as its chemical composition. The main objective of the present study was to reveal the potential of F. deltoidea leaf to be used as medicinal drug. Antimicrobial property of F. deltoidea leaf extract was revealed by using two fold dilution method whereas antioxidant activity of the extract was determined with α, α-diphenyl-β-picrylhydrazyl (DPPH) radical scavenging method. The anticancer property of the plant extract was revealed through Colorimetric MTT (tetrazolium) assay against human breast adenocarcinoma (MCF-7). Chemical compounds of the plant extract were screening and identified by using gas chromatography-mass spectrometry (GC-MS). The present study result showed that minimum inhibitory concentration (MIC) values of the plant extract against the tested bacterial isolates ranged from 31.26 to 125 mg/ l in which the plant extract can inhibit all the tested bacterial isolates. At the maximum concentration of the plant extract, it was only able to inhibit almost 30 % of DPPH while no anticancer activity was observed against MCF-7 cell. A total of 19 chemical compounds were successfully identified with the phenol 27.12 % and 2,4-bis (dimethylbenzyl)-6-t-butylphenol 11.83 % as the major compounds.